ABSTRACT
Background: Disimpaction of mandibular of third molar is one of the commonest minor oral surgical procedures. Platelet-rich fibrin (PRF) plays a vital role in both hard and soft tissue healing. There are various subtypes of PRF used for different surgical sites. Objective: The purpose of this study is to compare and evaluate the effectiveness of Advanced PRF (A-PRF) and Standard PRF (S-PRF) in the healing process of the surgical sites after the removal of mandibular third molars. Changes in swelling, pain, and mouth opening were evaluated. Materials and Methods: 10 patients (3 men, 7 women; 18-35 years old) were selected for the removal of bilateral impacted mandibular third molar teeth. A-PRF and S-PRF were placed in the right-hand side for 5 patients in each group. In both the groups, the left side of the patients was taken as the control group. Postoperative pain was measured using a visual analogue scale (VAS), postoperative swelling was calculated using the distance between multiple facial landmarks (method) and mouth opening measured interincisally on the 1st postoperative day, 3rd day, and the 7th day, respectively. SPSS version 26.0 was used for data analysis. Results: Advanced PRF group recorded noteworthy improvement in pain (P = 0.063), swelling (P = 0.001), and mouth opening (P = 0.013) when compared to the standard PRF group. There was statistically substantial variance between the advanced PRF and standard PRF groups. Conclusion: Advanced PRF group showed decreased swelling, pain, and increased mouth opening compared to standard PRF group.
ABSTRACT
Clinical treatment of inflamed tooth pulp mostly involves the removal of the entire pulp tissue. Because the vitality of the tooth is important for its ability to function, optimal regenerative biomaterials must be developed to maintain the vitality. Despite vast advances in the field of endodontics, the clinical translation of regenerative endodontic procedures and materials remains challenging. Patient-specific, tissue-derived stem cells play a major role in regeneration and revascularization, and these stem cells require an infection-free environment for a successful outcome. However, the high doses of antibiotics currently used to maintain an infection-free environment for tissue regeneration can be toxic for the stem cells. The introduction of nanotechnology in the field of regenerative procedures has overcome these issues and demonstrated promising results. Nanoparticles can be used to deliver antibiotics at very low doses owing to their small size, thereby enhancing antimicrobial activity and reducing the cytotoxic effect. Additionally, nanofibrous scaffolds provide an environment that is favorable for stem-cell migration and proliferation, thereby favoring the regeneration of the pulp-dentin complex. Nanotechnology can be used in the construction of nanofibrous scaffolds incorporated with different bioactive nanoparticles for favorable clinical outcomes. Nonetheless, the role of nanotechnology and the controlled release of various bioactive nanomolecules enhancing stem cell proliferation and regeneration of true pulp-dentin complex remains poorly understood. Given the importance of nanotechnology in tissue regeneration, this review provides an overview of the potential applications of nanotechnology in tooth pulp-dentin regeneration.
