ABSTRACT
The concentration of radionuclides in samples of soil collected in the region of the town of Nis, was measured and presented in this paper. The naturally occurring radionuclides, 226Ra, 232Th and 40K, were found in all samples. In many of them, 137Cs was also measured, while the other artificial radionuclides were not detected. The measurements were carried out using the standard gamma spectroscopy system with high purity germanium (HPGe) detector. The results show that the average activity concentrations of 226Ra, 232Th, 40K and 137Cs are: 21, 26, 414 and 4.7, in Bq/kg, respectively. The sediment in the municipality spa Niska Banja exhibits a high content of 226Ra, 573 Bq/kg. The outdoor dose rates, due to the gamma radiation of the ground, were also determined for all soils. The average absorbed dose rate in air was estimated to be 39 nGy/h, while the corresponding annual effective dose is 0.048 mSv.
Subject(s)
Cesium Radioisotopes/analysis , Potassium Radioisotopes/analysis , Radium/analysis , Soil Pollutants, Radioactive/analysis , Thorium/analysis , Calibration , Gamma Rays , Germanium , Probability , Radiation Dosage , Serbia , Spectrometry, GammaABSTRACT
The purpose of this study was to assess the feasibility of extemporaneous compounding of slow-release oral dosage form of niacinamide and to evaluate its release kinetics. The model formulation (preparation) was developed in the form of powder-filled hard gelatin capsules. Two slow-release preparations with different ratios of hypromellose have been prepared and evaluated in comparison with an immediate-release preparation. The dissolution tests were performed as per United States Pharmacopoeia requirements: Type I Apparatus, over 7 hours. Both slow-release preparations, containing 40% and 60% v/v hypromellose, respectively, have showed slow release kinetics. The dissolution profiles were significantly different, with similarity factor f2<50. The dissolution data demonstrated Korsmeyer-Peppas kinetics with n values indicating anomalous transport. In conclusion, the results of this study suggest that slow-release niacinamide capsules can be successfully compounded using hypromellose as a sole release rate modifier, and that the release mechanism is comparable to hydrophilic polymer matrix-based systems.
