ABSTRACT
The major cytotoxic activity of crude extracts of Nectandra rigida Nees is due to dehydrodiisoeugenol,the sample isolated being slightly enriched in the dextrorotatory enantiomer. Galgravin and two new tetrahydrofuranoid lignans, nectandrin A and nectandrin B, were also isolated and characterized along with small quantities of vanillin, 2,6-dimethoxybenzoquinone, and the known lauraceous alkaloid laurelliptine. The neolignans are of potential chemotaxonomic significance in the study of the Lauraceae.
Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Plants, Medicinal/analysis , Alkaloids/isolation & purification , Cell Line , Humans , Nasopharyngeal Neoplasms , Neoplasms, Experimental , Plant Extracts/pharmacologySubject(s)
Animal Feed/analysis , Toxins, Biological/isolation & purification , Animal Feed/toxicity , Animals , Cattle , Chickens , Female , Male , Mice , Sheep , SolventsABSTRACT
Several hundred flavonoid derivatives, natural and synthetic, which have been tested in the screening program of the National Cancer Institute, have been examined for indications of structure-activity relationships which might exist among these compounds. No such relationships are apparent. In spite of occasional activity these compounds do not warrant further detailed pursuit as anti-tumor agents.
Subject(s)
Antineoplastic Agents , Flavonoids/pharmacology , Isoflavones/pharmacology , Animals , Humans , Structure-Activity RelationshipABSTRACT
The stem bark and stem wood of Cinchona pubescens were found to owe their weak cytotoxic activity to the presence of quinovic acid. This acid and its 3-rhamnoside were isolated and characterized through several derivatives, all of which were assayed for their cytotoxicity.
Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Cinchona/analysis , Plants, Medicinal , Antineoplastic Agents, Phytogenic/therapeutic use , Neoplasms, Experimental/drug therapy , PhytotherapyABSTRACT
beta-Sitosterol, epilupeo, amarolide-11-acetate, amarolide-2,11-diacetate, ailanthinone and glaucarubinone have been isolated from S. versicolor. The cytotoxic and antileukemic activities of extracts of this plant are due chiefly to glaucarubinone.
