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Bioorg Med Chem Lett ; 29(9): 1043-1046, 2019 05 01.
Article in English | MEDLINE | ID: mdl-30871771

ABSTRACT

Neuropathic pain is a debilitating form of treatment-resistant chronic pain caused by damage to the nervous system. Cannabinoids have been known for suppressing neuropathic pain by modulating the endo cannabinoid system. Since the canonical Wnt/ß-catenin signaling has recently been implicated in pain sensation, we investigated the impact of major cannabinoids (1-6) from the leaves of Cannabis sativa and an epoxy derivative of compound 2, here upon referred to as 2a, on modulating Wnt/ß-catenin signaling pathway. The results presented in this study show that compound 1, 2 and 2a exhibited potent inhibitory activity against Wnt/ß-catenin pathway in a dose-dependent manner. Compound 2a was seen to inhibit this pathway at slightly lower concentrations than its parent molecule 2, under similar conditions. Taken together, compound 1, 2 and 2a, by virtue of their inhibition of Wnt/ß-catenin signaling pathway, could be developed as effective neuroprotective agents for the management of neuropathic pain.


Subject(s)
Cannabinoids/chemistry , Wnt Signaling Pathway/drug effects , Animals , Cannabinoids/pharmacology , Cannabinoids/therapeutic use , Cannabis/chemistry , Cannabis/metabolism , Cell Line, Tumor , Cell Proliferation/drug effects , Humans , Neuralgia/drug therapy , Neuralgia/pathology , Plant Leaves/chemistry , Plant Leaves/metabolism
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