Increasing diagnostic certainty: the clinical value of the likelihood ratio.

The LR has the potential to be a valuable tool to mitigate uncertainty in the diagnostic process for clinicians in any area of medicine. With more and more LRs being published in the literature and the ready availability of the likelihood nomogram, there has never been a better time to put this tool to work in both inpatient and outpatient settings. PA students can be exposed initially to LRs in their diagnostic medicine lectures, followed by application of the principles in case-based exercises in clinical medicine or as part of their evidence-based medicine curriculum. Clinical-year PA students can then be encouraged to use LRs in their clinical rotations as they collaborate with preceptors in the diagnostic decision-making process. Exposure to and application of LRs in the didactic and clinical aspects of the curriculum are likely to increase their comfort level with this valuable tool and enable them to use it with ease in their future clinical practices.

Hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in the United States--September-October 2009.

Given the potential worsening clinical severity of 2009 pandemic influenza A (H1N1) virus (pH1N1) infection from spring to fall 2009, we conducted a clinical case series among patients hospitalized with pH1N1 infection from September through October 2009. A case patient was defined as a hospitalized person who had test results positive for pH1N1 virus by real-time reverse-transcription polymerase chain reaction. Among 255 hospitalized patients, 34% were admitted to an intensive care unit and 8% died. Thirty-four percent of patients were children <18 years of age, 8% were adults ≥ 65 years of age, and 67% had an underlying medical condition. Chest radiographs obtained at hospital admission that had findings that were consistent with pneumonia were noted in 103 (46%) of 255 patients. Among 255 hospitalized patients, 208 (82%) received neuraminidase inhibitors, but only 47% had treatment started ≤ 2 days after illness onset. Overall, characteristics of hospitalized patients with pH1N1 infection in fall 2009 were similar to characteristics of patients hospitalized with pH1N1 infection in spring 2009, which suggests that clinical severity did not change substantially over this period.

Florida Epidemic Intelligence Service Program: the first five years, 2001-2006.

The Florida Epidemic Intelligence Service Program was created in 2001 to increase epidemiologic capacity within the state. Patterned after applied epidemiology training programs such as the Centers for Disease Control and Prevention Epidemic Intelligence Service and the California Epidemiologic Investigation Service, the two-year postgraduate program is designed to train public leaders of the future. The long-term goal is to increase the capacity of the Florida Department of Health to respond to new challenges in disease control and prevention. Placement is with experienced epidemiologists in county health departments/consortia. Fellows participate in didactic and experiential components, and complete core activities for learning as evidence of competency. As evidenced by graduate employment, the program is successfully meeting its goal. As of 2006, three classes (n=18) have graduated. Among graduates, 83% are employed as epidemiologists, 67% in Florida. Training in local health departments and an emphasis on graduate retention may assist states in strengthening their epidemiologic capacity.