ABSTRACT
Squamous cell cancer among young adults is rare and thought to have aggressive biological behaviour and poor prognosis. Clinical case records of 76 patients under the age of 45 years treated for squamous cell carcinoma (SCC) of the oral tongue were retrospectively analysed to calculate the survival rates and the predictors of survival. The overall survival (OS) and disease free survival (DFS) at 5 year were 78.0% and 57.4% respectively. Tumour status, pathological node status, surgical clearance, the selection of appropriate treatment, type of primary and neck surgery, were found to significantly influence the survival rates. Young patients with SCC of the oral tongue were seen to have a comparable outcome and prognosis compared to that in older patients.
Subject(s)
Carcinoma, Squamous Cell/mortality , Tongue Neoplasms/mortality , Adult , Age Factors , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Disease-Free Survival , Female , Forecasting , Humans , Linear Models , Lymphatic Metastasis/pathology , Male , Middle Aged , Neoplasm Staging , Prognosis , Retrospective Studies , Statistics, Nonparametric , Survival Rate , Tongue Neoplasms/pathology , Tongue Neoplasms/surgery , Treatment OutcomeABSTRACT
1-Phenyl-3-(4-morpholinyl)propan-1-one hydrochloride 1 and the related piperidino derivative 2 were shown to have activity against the EMT6 tumour in vitro. Modification of the structures of these compounds by introducing a glucosyloxy group onto the aryl rings lowered cytotoxicity but conversion of 1 and 2 into the corresponding bis-Mannich bases increased bioactivity considerably.
Subject(s)
Acetophenones/pharmacology , Antineoplastic Agents , Mannich Bases/pharmacology , Tumor Cells, Cultured/drug effects , AnimalsABSTRACT
Pyrolysis-gas chromatography was applied to the characterization of ground beef and soy protein isolate and its mixtures at the 50, 30 and 10% levels. A cryogenic trap pyrolysis mode was employed and the volatile pyrolysates were analysed by a high-resolution capillary gas chromatograph. Two phenolic derivatives, o-methoxy- and dimethoxyphenol, as well as 2,3-dithiabutane are uniquely observed at a large concentration in the soy pyrolysate. Quantification of these characteristic compounds allow the estimation of the level of soy inclusion in the mixture. This approach effectively denotes soy addition up to the 10% level in comminuted beef.
Subject(s)
Meat/analysis , Plant Proteins, Dietary/analysis , Animals , Cattle , Chromatography, Gas , Mass Spectrometry , Soybean ProteinsABSTRACT
Series of 3-dimethylamino-1-aryl-1-propanone hydrobromides (IV) and 3-dimethylamino-2-dimethylaminomethyl-1-aryl-1-propanone dihydrobromides (V) were synthesized. Evaluation of these derivatives against P-388 lymphocytic leukemia growth revealed that two compounds show promise as antineoplastic agents. Compounds of the V series were unstable in phosphate buffer (in contrast to series IV), and when the same nuclear substituent was present in both series of compounds, V was approximately 100 times more active than IV in both the stimulation and inhibition of respiration of mitochondria isolated from rat liver cells. Representatives from both series showed that respiration in mitochondria was affected by changing the pH of the aqueous buffer from 7.4 to 6.9 or 6.4 and by reducing the temperature from 37 degrees to 20 degrees. The compounds showed reactivity toward a biomimetic thiol.
