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1.
Heliyon ; 9(8): e19077, 2023 Aug.
Article in English | MEDLINE | ID: mdl-37636443

ABSTRACT

The drive to achieve the Sustainable Development Goals (SDGs) becomes more urgent as the 2030 deadline draws near, increasing research in various sectors. Nevertheless, studies that systematically map Analytical Hierarchy Process (AHP) publications with the SDGs need to be more conspicuously lacking. Our study adds a new perspective to the field by creatively bridging this knowledge gap using the Elsevier SDG Mapping Initiative. To find research clusters, trends, and themes linked to SDGs and their connection to environmental sustainability, we thoroughly analyzed 29,897 publications from 2012 to 2022. The analysis showed that SDG 15, SDG 7, SDG 12, SDG 13, and SDG 11 were the top five SDGs, with an environmental focus among the 17 SDGs. These top SDGs had many clusters connected to them, illustrating various sustainability-related problems. The study also looked at connections between SDGs, the nations with the highest rates of productivity, the top contributors, and the journals with the highest citation counts. We discovered three separate SDG clusters using co-occurrence network analysis, each representing a different SDG. We discovered relevant SDGs using Matrice d'impacts croisés multiplication appliquée á un classment (MICMAC) analysis and centrality indicators like eigenvector and betweenness. This novel method for publishing analysis combines an AHP focus that aligns with the SDGs with social network analysis and centrality metrics. Our research advances knowledge of how the AHP technique can assess initiatives supporting the SDGs. We offer essential insights into prioritizing sustainable development measures by identifying research clusters, trends, and issues related to environmental sustainability. This study highlights the subject's most important SDGs, productive nations, helpful organizations, and significant journals.

2.
Cartilage ; 13(1_suppl): 1696S-1701S, 2021 12.
Article in English | MEDLINE | ID: mdl-34696623

ABSTRACT

OBJECTIVES: This work studied if and how current clinical practice agrees with European Viscosupplementation Consensus Group (EUROVISCO) recommendations and how this agreement might be different according to physician's specialization. In addition, this work aimed to identify key decision factors that practitioners consider in their decision to retreat or not a patient with hyaluronic acid viscosupplementation. METHODS: Practitioners have been invited by e-mail to participate in an online exercise on viscosupplementation retreatment. They received a fictional patient case at random among a set of predefined fictional cases. The platform asked the practitioner if he/she would retreat the patient with viscosupplementation or not. To take a decision, the practitioner could select questions among a list of predefined questions. Among them, some were related to criteria used in the EUROVISCO decision tree and others served as confounding factors. RESULTS: A total of 506 practitioners participated to the exercise, of which 399 gave their decision about the case assigned to them by the platform. The observed agreement between practitioner decisions and EUROVISCO recommendations was 58.89 ± 4.95% (95% confidence interval [CI]). Overall, the decision to retreat was taken in 47.87% of the cases, while the EUROVISCO guidelines follow-up would have led to 55.89% retreatment for the same cases (P = 0.03). CONCLUSIONS: In current practice, physicians tended to reinject their patients less than recommended, although EUROVISCO guidelines for viscosupplementation retreatment consider decision criteria that clearly correspond to those of practitioners in real life. These include the patients' willingness to be treated or the patients' perception of the effectiveness of the treatment.


Subject(s)
Osteoarthritis, Knee , Viscosupplementation , Consensus , Female , Humans , Hyaluronic Acid/therapeutic use , Osteoarthritis, Knee/drug therapy , Retreatment , Viscosupplements/therapeutic use
3.
Waste Manag ; 57: 91-101, 2016 Nov.
Article in English | MEDLINE | ID: mdl-26597370

ABSTRACT

This paper investigates the high temperature transformation, specifically the kinetic behaviour of the waste printed circuit board (WPCB) derived from computer monitor (single-sided/SSWPCB) and computer processing boards - CPU (multi-layered/MLWPCB) using Thermo-Gravimetric Analyser (TGA) and Vertical Thermo-Gravimetric Analyser (VTGA) techniques under nitrogen atmosphere. Furthermore, the resulting WPCB residues were subjected to characterisation using X-ray Fluorescence spectrometry (XRF), Carbon Analyser, X-ray Photoelectron Spectrometer (XPS) and Scanning Electron Microscopy (SEM). In order to analyse the material degradation of WPCB, TGA from 40°C to 700°C at the rates of 10°C, 20°C and 30°C and VTGA at 700°C, 900°C and 1100°C were performed respectively. The data obtained was analysed on the basis of first order reaction kinetics. Through experiments it is observed that there exists a substantial difference between SSWPCB and MLWPCB in their decomposition levels, kinetic behaviour and structural properties. The calculated activation energy (EA) of SSWPCB is found to be lower than that of MLWPCB. Elemental analysis of SSWPCB determines to have high carbon content in contrast to MLWPCB and differences in materials properties have significant influence on kinetics, which is ceramic rich, proving to have differences in the physicochemical properties. These high temperature transformation studies and associated analytical investigations provide fundamental understanding of different WPCB and its major variations.


Subject(s)
Computers , Electronic Waste , Recycling/methods , Carbon , Hot Temperature , Kinetics , Microscopy, Electron, Scanning , Nitrogen , Photoelectron Spectroscopy , Thermogravimetry
4.
Tumour Biol ; 34(1): 99-105, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23001908

ABSTRACT

Transformation growth factor ß1 is a multipotent cytokine that mediates the development, differentiation, and neoplasm of the mammary gland. TGF ß1 is known to exert both tumor suppressive and progressive effect at different stages of carcinogenesis. Several studies have shown the association of TGF ß1 expression with breast cancer markers like estrogen receptor (ER), progesterone receptor (PR), and Her2/neu. TGF ß1 expression is known to be influenced by -509C/T promoter polymorphism. Hence, the present study is aimed to evaluate the possible role of TGF ß1 -509C/T promoter polymorphism in breast cancer and its association with ER, PR, and Her2 status based on case-control study in South Indian population from Andhra Pradesh. Our study revealed a significant increase of CT genotype in breast cancer patients compared to controls (CT vs. CC: χ (2) = 6.054, P = 0.014, OR 2.005, 95 % CI 1.182-3.403). However, there was no correlation between TGF ß1 -509C/T polymorphism and other factors like age at onset, ER, PR, Her2 status, etc. Further, CT genotype was found to be associated with increased risk in advanced stages of breast cancer (CC vs. CT: OR 2.315, 95 % CI 1.143-4.688) and a border line significance with postmenopausal women (CT vs. CC: χ (2) = 3.128, P = 0.07, OR 2.095, 95 % CI 0.991-4.428).


Subject(s)
Breast Neoplasms/genetics , Heterozygote , Transforming Growth Factor beta1/genetics , Breast Neoplasms/metabolism , Case-Control Studies , Female , Genetic Predisposition to Disease , Genotype , Humans , India , Polymorphism, Single Nucleotide , Postmenopause , Promoter Regions, Genetic , Receptor, ErbB-2/metabolism , Receptors, Estrogen/metabolism , Receptors, Progesterone/metabolism , Risk
5.
Acta Biomater ; 8(1): 361-72, 2012 Jan.
Article in English | MEDLINE | ID: mdl-21925626

ABSTRACT

An alkali-free series of bioactive glasses has been designed and developed in the glass system CaO-MgO-SiO(2)-P(2)O(5)-CaF(2) along the diopside (CaMgSi(2)O(6))-fluorapatite (Ca(5)(PO(4))(3)F)-tricalcium phosphate (3CaO·P(2)O(5)) join. The silicate network in all the investigated glasses is predominantly coordinated in Q(2) (Si) units, while phosphorus tends to remain in an orthophosphate (Q(0)) environment. The in vitro bioactivity analysis of glasses has been made by immersion of glass powders in simulated body fluid (SBF) while chemical degradation has been studied in Tris-HCl in accordance with ISO-10993-14. Some of the investigated glasses exhibit hydroxyapatite formation on their surface within 1-12 h of their immersion in SBF solution. The sintering and crystallization kinetics of glasses has been investigated by differential thermal analysis and hot-stage microscopy, respectively while the crystalline phase evolution in resultant glass-ceramics has been studied in the temperature range of 800-900°C using powder X-ray diffraction and scanning electron microscopy. The alkaline phosphatase activity and osteogenic differentiation for glasses have been studied in vitro on sintered glass powder compacts using rat bone marrow mesenchymal stem cells. The as-designed glasses are ideal candidates for their potential applications in bone tissue engineering in the form of bioactive glasses as well as glass/glass-ceramic scaffolds.


Subject(s)
Alkalies/chemistry , Bone Regeneration/physiology , Bone and Bones/physiology , Glass/chemistry , Tissue Engineering/methods , Animals , Apatites/chemistry , Apatites/metabolism , Biocompatible Materials/chemistry , Biocompatible Materials/metabolism , Body Fluids/chemistry , Bone and Bones/pathology , Cells, Cultured , Ceramics/chemistry , Hot Temperature , Humans , Materials Testing , Mesenchymal Stem Cells/cytology , Mesenchymal Stem Cells/physiology , Rats , Spectroscopy, Fourier Transform Infrared , Surface Properties , X-Ray Diffraction
6.
Acta Biomater ; 7(11): 4071-80, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21763793

ABSTRACT

The present study investigates the influence of SrO on structure, apatite-forming ability, physico-chemical degradation and sintering behaviour of melt-quenched bioactive glasses with the composition (mol.%): (36.07 - x) CaO-xSrO-19.24MgO-5.61P(2)O(5)-38.49SiO(2)-0.59CaF(2), where x varies between 0 and 10. The detailed structural analysis of the glasses is made by infrared spectroscopy and magic angle spinning-nuclear magnetic resonance spectroscopy. Silicon is predominantly present as Q(2) (Si) species, while phosphorus is found as orthophosphate in all the investigated glasses. The apatite-forming ability of glasses is investigated by immersion of glass powders in simulated body fluid for time durations varying between 1 h and 7 days. While increasing the Sr(2+)/Ca(2+) ratio in the glasses does not affect their structure significantly, their apatite-forming ability is decreased considerably. Further, physico-chemical degradation of glasses is studied in accordance with ISO 10993-14 "Biological evaluation of medical devices - Part 14: Identification and quantification of degradation products from ceramics" in Tris-HCl and citric acid buffer, and the possible implications of the ion release profiles from the glasses in different solutions are discussed. The addition of strontium to the glasses leads to a sevenfold decrease in chemical degradation of glasses in Tris-HCl. The sintering of glass powders renders glass ceramics (GCs) with varying degrees of crystallinity and good flexural strength (98-131 MPa), where the mechanical properties depend on the nature and amount of crystalline phases present in the GCs.


Subject(s)
Apatites/chemistry , Glass/chemistry , Materials Testing , Strontium/chemistry , Stress, Mechanical
7.
Med J Armed Forces India ; 66(2): 188-9, 2010 Apr.
Article in English | MEDLINE | ID: mdl-27375335
8.
Indian J Pediatr ; 72(12): 1047-8, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16388155

ABSTRACT

Pseudotumor cerebri is a clinical syndrome characterized by raised intracranial pressure with normal ventricular size, anatomy and position. Headache, vomiting and diplopia are the most common symptoms. Signs include those of raised intracranial pressure including papilledema and absence of focal neurological signs. A secondary cause is identifiable in 50% of children; the most common predisposing conditions are otitis media, viral infection and medications. Management is mainly directed towards identifying and treating the cause and measures to reduce the raised intracranial pressure. Though it is mostly a self limited condition, optic atrophy and blindness can occur. Oculomotor nerve palsy is very rarely associated with pseudotumor cerebri. We report a unique case of pseudotumor cerebri who had left Oculomotor palsy with sparing of the pupillary fibres, which resolved following treatment with oral acetazolamide.


Subject(s)
Oculomotor Nerve Diseases/etiology , Pseudotumor Cerebri/diagnosis , Child , Diplopia/etiology , Humans , Male , Oculomotor Nerve Diseases/diagnosis , Pseudotumor Cerebri/complications
10.
Med J Armed Forces India ; 60(2): 211-2, 2004 Apr.
Article in English | MEDLINE | ID: mdl-27407630
11.
Med J Armed Forces India ; 57(2): 110-3, 2001 Apr.
Article in English | MEDLINE | ID: mdl-27407310

ABSTRACT

This prospective, cross sectional population study was carried out to determine the relationship between maternal haemoglobin concentration and birth weight in different socioeconomic groups in a tertiary care teaching hospital. 500 cases each from two teaching hospitals about whom information on socioeconomic status, haemoglobin concentration and birth weight was known were included in the study. This was a stratified random study based on the preselected inclusion and exclusion criteria. 149 (14.9%) women belonged to upper socioeconomic group, 119 (11.9%) to upper middle, 125 (12.5%) to lower middle, 90 (9.0%) to upper lower and 517 (51.7%) to lower group. Mean haemoglobin level was found to be lower in low socioeconomic group as compared to high socioeconomic group and was statistically significant (F value of 18.2521 & p 0.000). The lowest Hb level was 4.0g/dl and highest was 15.0g/dL Majority of pregnant women (89.3%) had their lowest haemoglobin level during the second trimester as compared to first trimester (0.8%) and third trimester (9.9%). The mean birth weight in upper socioeconomic group was 2.7508 kg, 2.7556 kg in upper middle group, 2.8802 kg in lower middle group, 2.7876 kg in upper lower group and 2.7515 in lower socioeconomic group. By analysis of variance test it was found that the mean birth weight did not vary significantly between different socioeconomic groups with an F value of 1.3398 and p value of 0.2450. The correlation analysis of haemoglobin concentration with birth weight suggested that for every rise of haemoglobin concentration by 1.0g/dl the birth weight reduced by 03839 kg (highly significant p < 0.001). In the present study there was significant inverse relationship of maternal haemoglobin concentration to birth weight Results are in agreement with the hypothesis that a higher blood viscosity is a risk factor for sub optimal placenta-perfusion.

12.
Med J Armed Forces India ; 56(3): 219-224, 2000 Jul.
Article in English | MEDLINE | ID: mdl-28790712

ABSTRACT

Failure to thrive is a commonly encountered problem in Paediatric practice. This essentially generic term refers to children whose attained weight or rate of weight gain is significantly below that of other children of similar age and same sex. Several defining criteria have been proposed and help to differentiate true failure to thrive from other conditions causing apparent growth failure. There are numerous organic causes of failure to thrive, but non-organic failure to thrive is also an important entity and is caused by social, psychological and environmental factors. The clinical features are those of malnutrition, signs of underlying organic cause and specific manifestations of environmental/psychosocial deprivation. Indiscriminate laboratory investigations are usually non-contributory and have no role in evaluation. Management requires a multidisciplinary approach and hospitalization has a specific role. Although nutritional rehabilitation is the cornerstone of therapy, treatment of underlying factors-medical, psychological, social and environmental-should receive equally important attention. Long term physical, developmental and behavioural sequelae are known to occur in children with failure to thrive.

15.
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