[The age changes of lymphoid organs structure: review of literature].

Numerous and often contradictory research results specify that the mechanism of increased susceptibility to diseases in old age has no satisfactory explanation so far. Together with it in literature almost completely there are no comparative data on features of surgery and injury influence on a structure and functions of lymphoid organs at patients of different age groups. However, lymph nodes are a marker of activity of inflammatory process in the region, on their changes it is possible to estimate precisely productivity of different medical actions, to predict development of many complications, and, thus, successfully to take actions for their prophylaxis. All this is especially important and actual because of constant increase in average age, in life expectancy of human population and strengthening of surgical activity at patients of advanced and old age.

The features of lymph node reactions to tissue damage of lymph collecting region at old rats.

The features of submandibular lymph node (LN) reactions after lower jaw tissue damage at old rats were studied by method of light microscopy. In LN of old rats for all terms of observation, including intact control, the volume of connective tissue is considerable increased. Besides, old animals in LN have of more change duration of a cortical plateau volume, less - of paracortex and lymphoid nodules without light centers. Features of cellular element number consisted in considerable decrease in quantity of lymphocytes, mitotic figures, immunoblasts and plasmablasts against increase in keeping of macrophages, cells with destruction, stromal elements and erythrocytes.

[Changes in the mucous membranes of the oral cavity in chronic renal failure (experimental study)].

Methods of light microscopy were used to study the morphological changes of the oral cavity mucosa in rats (n = 48) in chronic renal failure (CRF) of various degrees. It was found that after 6 months of modeling of mild and moderate CRF, lamina propria of the oral cavity mucous membranes was diffusely infiltrated with leukocytes. At the same time, relative density of the distribution of the components of blood and lymphatic vascular bed was increased. In severe CRF, the atrophy and hyperkeratosis of the epithelium of the oral cavity mucous membrane developed, while the lamina propria demonstrated sclerosis and significant increase of leukocyte (primarily neutrophil and monocyte) and macrophage numerical density with the formation of small leukocyte infiltrates. In addition, in moderate and severe CRF, the number of eosinophils and plasma cells was increased in the lamina propria which indicates the possible presence of allergic component in the initiation and maintenance of its inflammation.

[Oral cavity pathology by renal failure].

The analysis of the scientific literature devoted to organ and tissue changes of oral cavity at the chronic renal insufficiency (CRI)is made. The number of patients in an end-stage of CRI constantly increases and patients receiving renal replacement therapy including hemodialysis, peritoneal dialysis or renal transplantation will comprise an enlarging segment of the dental patient population. Owing to CRI and its treatment there is a set of changes of teeth and oral cavity fabrics which remain even in a end-stage. Renal replacement therapy can affect periodontal tissues including gingival hyperplasia in immune suppressed renal transplantation patients and increased levels of bacterial contamination, gingival inflammation, formation of calculus, and possible increased prevalence and severity of destructive periodontal diseases. Besides, the presence of undiagnosed periodontitis may have significant effects on the medical management of the patients in end-stage of CRI.

[Adjusting gingival tissues morphology after dental implantation with fibrin use].

In gingival tissues of 62 patients after dental implantation of traditional type and with the use of thrombocyte rich fibrin preparation (TRFP) microcirculation and leucocytal infiltration were studied. It was disclosed that in all terms after titanium screw dental implant setting lymphostasis and leucocytal infiltration were seen as signs of active inflammatory process in gingival tissues. 3 months later after implants setting with the use of TRFP the lymphatic vessels status was normalized, the degree of leucocytal infiltration was reduced; when implantation was made without use of fibrin technologies in gingival tissues more leucocytes were found and lymphatic bed components were remained dilated. Besides fibrin preparation use in the process of dental implantation promoted quicker and stronger implant fixation, but granulomatous inflammatory process could develop and amount of eosinophils in gingival tissues could also increased.