ABSTRACT
One clinical and pathomorphologic case of Landry paralysis with a proven etiological role of herpetic infection is reported. Acute clinical syndrome developed as a manifestation of exacerbation of chronic inflammation in the central nervous system. Advancement of the process and generalisation of herpetic infection was connected with immunodeficiency in this patient.
Subject(s)
Herpesviridae Infections/diagnosis , Paralysis/diagnosis , Polyneuropathies/diagnosis , Adult , Humans , Male , Paralysis/virology , Polyneuropathies/virology , SyndromeABSTRACT
A study was made of the adrenaline and noradrenaline content in the blood, myocardium and adrenals of 74 male Wistar rats. Four series of experiments were conducted with administration of noradrenaline alone and noradrenaline after premedication with arfonad (ganglion-blocking agent) or rausedil (reserpine drug). Distilled water was used in control experiments. The content of adrenaline and noradrenaline in blood and tissues was shown to change 45 seconds after noradrenaline administration and to return to normal by the 7th minute. Correlation of the catecholamine content in rat blood and tissues with morphological changes in the myocardium recorded in the analogous series of experiments has shown that the increased content of catecholamines in bloods is one of the most important factors in the pathogenesis of myocardial injury since the diminution of their content during ganglionic blockade is associated with a reduced heart injury. The noradrenaline content in the myocardium does not correlate with the severity of myocardial injury.
Subject(s)
Adrenal Glands/analysis , Cardiomyopathies/metabolism , Catecholamines/analysis , Myocardium/analysis , Norepinephrine/poisoning , Animals , Cardiomyopathies/chemically induced , Catecholamines/blood , Rats , Reserpine , TrimethaphanABSTRACT
The article discusses advantages of the so-called fuchsinorrhagic method offered by Lie et al. in 1971. Areas of the necrotized muscle obtained at autopsy of 11 individuals who had died of myocardial infarction of various periods of duration, 12 biopsy specimens of the myocardium obtained during the operation for correction of congenital heart defects of the type of Fallot's tetrad and isolated defects of the septum with various periods of extracorporeal circulation and hearts of 35 male Wistar rats with a damaged myocardium (lesions being induced by intro-abdominal injection of noradrenalin in a dose of 2.5 mg/kg), which were sacrified 6 hours following the exposure to noradrenalin, were studied. The method of staining with HBFP makes it possible to detect both ischemic and noncoronarogenic lesions of the myocardium; moreover, in this method erythrocytes, fibrin, and connective structures get also stained, which makes a complex study of morphology of the myocardium feasible.