WITHDRAWN: Assessment of the activity of posaconazole against azole-resistant Aspergillus species studied in an in vitro pharmacokinetic/pharmacodynamic model.

Ahead of Print article withdrawn by publisher.

LINAGLIPTIN AND GLICLAZIDE DI-LOADED EXTENDED-RELEASE NANOPARTICLES: FORMULATION AND EVALUATION.

OBJECTIVE: The aim: This work aimed to formulate gliclazide and linagliptin extended-release nanoparticles. PATIENTS AND METHODS: Materials and methods: A HPLC method was developed and validated to determine gliclazide and linagliptin at the same time without interference. The nanoparticles were prepared by emulsion solvent evaporation using two polymers, namely hydroxypropyl methylcellulose (HPMC) 4000 cps and xanthan gum. RESULTS: Results: Nanoparticles prepared were characterized for drug contents, production yield and entrapment efficiency, zeta potential, particle size, morphology by transmission electronic microscopy (TEM) and in-vitro release rate. The formulae GLH1, GLX1 and GHX1 showed release of linagliptin more than 75% after 8 hrs. While the only formula among the three (GHX1) showed release of gliclazide more than 80% after 8 h. So, the formula GHX1 showed acceptable release of more than 80% of both gliclazide and linagliptin after 8 h. CONCLUSION: Conclusions: The formula GHX1 which containing (0.5:1 xanthan gum: drugs) was the best nanoparticles formula which released more than 80% of both drugs after 8 h and could achieve good extended release over 24 h.

DEVELOPMENT OF CONTINUOUS ANTI-SOLVENT RECRYSTALLIZATION METHOD TO PRODUCE CEFTRIAXONE SODIUM NANO CRYSTALS INJECTION USING CERAMIC FILTRATION.

OBJECTIVE: The aim: In this work we developed a method of continuous recrystallization to meet industrial requirements. PATIENTS AND METHODS: Materials and methods: Continuous recrystallization method was investigated using porous ceramic filter for water purification with pour size less than 1 µm, that ensures high mixing rate of ethanol and water. RESULTS: Results and conclusions: The results of experiments using crystallization through ceramic filter, gives superior products in particle size, and produced needle shaped ceftriaxone crystals form, that showed significant improvement in dissolution time and obtained ceftriaxone sodium powder to be reconstituted in injectable formula that give clear solution without insoluble microparticles.