Self-Assembled Hydrogel Membranes with Structurally Tunable Mechanical and Biological Properties.

Using supramolecular self-assembled nanocomposite materials made from protein and polysaccharide components is becoming more popular because of their unique properties, such as biodegradability, hierarchical structures, and tunable multifunctionality. However, the fabrication of these materials in a reproducible way remains a challenge. This study presents a new evaporation-induced self-assembly method producing layered hydrogel membranes (LHMs) using tropocollagen grafted by partially deacetylated chitin nanocrystals (CO-g-ChNCs). ChNCs help stabilize tropocollagen's helical conformation and fibrillar structure by forming a hierarchical microstructure through chemical and physical interactions. The LHMs show improved mechanical properties, cytocompatibility, and the ability to control drug release using octenidine dihydrochloride (OCT) as a drug model. Because of the high synergetic performance between CO and ChNCs, the modulus, strength, and toughness increased significantly compared to native CO. The biocompatibility of LHM was tested using the normal human dermal fibroblast (NHDF) and the human osteosarcoma cell line (Saos-2). Cytocompatibility and cell adhesion improved with the introduction of ChNCs. The extracted ChNCs are used as a reinforcing nanofiller to enhance the performance properties of tropocollagen hydrogel membranes and provide new insights into the design of novel LHMs that could be used for various medical applications, such as control of drug release in the skin and bone tissue regeneration.

Art perception is affected by negative knowledge about famous and unknown artists.

The biographies of some celebrated artists are marked by accounts that paint a far from beautiful portrait. Does this negative-social knowledge influence the aesthetic experience of an artwork? Does an artist's fame protect their paintings from such an influence? We present two preregistered experiments examining the effect of social-emotional biographical knowledge about famous and unknown artists on the reception and perception of their paintings, using aesthetic ratings and neurocognitive measures. In Experiment 1, paintings attributed to artists characterised by negative biographical information were liked less, evoked greater feelings of arousal and were judged lower in terms of quality, than paintings by artists associated with neutral information. No modulation of artist renown was found. Experiment 2 fully replicated these behavioural results and revealed that paintings by artists associated with negative social-emotional knowledge also elicited enhanced early brain activity related to visual perception (P1) and early emotional arousal (early posterior negativity; EPN). Together, the findings suggest that negative knowledge about famous artists can shape not only explicit aesthetic evaluations, but may also penetrate the perception of the artwork itself.

Emotional content reduces the cognitive effort invested in processing the credibility of social (mis)information.

Emotionality likely is a key factor affecting our susceptibility to misinformation. However, the mechanisms underlying this observation are not well understood. Specifically, when people derive social information from person-related news, they rely predominantly on emotional content, apparently unperturbed by the credibility of the source. To help explain this bias, we here contrast two hypotheses of information processing reflected in changes in pupil size during news-based judgments: Emotion and cognitive effort. Thirty participants were first exposed to websites of well-known trusted or distrusted news media sources exhibiting headlines about unfamiliar persons, followed by social judgments. As expected, emotional relative to neutral headline contents lead to faster and more strongly valenced judgments. In line with the cognitive effort hypothesis, credibility modulated pupil size with larger pupils for headlines from distrusted sources, however only in response to neutral headline contents. Source credibility did not modulate pupil size in response to emotional headline contents. Instead, pupil size was smaller for emotional compared to neutral headlines for both trusted and distrusted sources. This pattern of findings suggests that emotional contents yield fluent social judgments that are made with relatively little mental effort-even if based on untrustworthy news. Cognitive resources to evaluate the credibility of news may primarily be allocated when emotional contents providing (false) fluency are not available. This insight into the biases underlying the processing of potential misinformation may be used as a protection against biased opinions and judgments. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Distrust before first sight? Examining knowledge- and appearance-based effects of trustworthiness on the visual consciousness of faces.

The present EEG study with 32 healthy participants investigated whether affective knowledge about a person influences the visual awareness of their face, additionally considering the impact of facial appearance. Faces differing in perceived trustworthiness based on appearance were associated with negative or neutral social information and shown as target stimuli in an attentional blink task. As expected, participants showed enhanced awareness of faces associated with negative compared to neutral social information. On the neurophysiological level, this effect was connected to differences in the time range of the early posterior negativity (EPN)-a component associated with enhanced attention and facilitated processing of emotional stimuli. The findings indicate that the social-affective relevance of a face based on emotional knowledge is accessed during a phase of attentional enhancement for conscious perception and can affect prioritization for awareness. In contrast, no clear evidence for influences of facial trustworthiness during the attentional blink was found.

An eco-friendly, highly efficient, and transparent coating derived from guar gum and citric acid for flame retardant treatment of cotton fabrics.

A highly efficient, bio-ecofriendly, and transparent flame retardant (FR) for cotton fabric was developed and deposited onto the cellulose skeletal structure of cotton fabric through a one-pot sol-gel process. The flame retardant functional coating is composed of ammonium polyphosphate (APP), guar gum (GG), citric acid (CA), and a negligible amount of catalyst. Cotton fabrics were impregnated with different concentrations of ammonium polyphosphate and guar gum, with citric acid as a crosslinking agent. The overall crosslinking and grafting process was proven by FTIR and XPS. Based on the results, the designed coating exhibits over 90 % transmittance in the visible region. A 15 g/m2 flame-retardant coating induces excellent flame retardant efficiency at ultra-low flame-retardant concentrations of less than 6.25 wt%. Only a 5.25 wt% flame retardant concentration demonstrated condensed phase action, which resulted in 58.5 % and 73.6 % reductions in the pHRR and THR, respectively. Moreover, the limiting oxygen index (LOI) value showed a 74 % increase. The mechanical performance of FR coated cotton fibers was slightly reduced.

Deepfake smiles matter less-the psychological and neural impact of presumed AI-generated faces.

High-quality AI-generated portraits ("deepfakes") are becoming increasingly prevalent. Understanding the responses they evoke in perceivers is crucial in assessing their societal implications. Here we investigate the impact of the belief that depicted persons are real or deepfakes on psychological and neural measures of human face perception. Using EEG, we tracked participants' (N = 30) brain responses to real faces showing positive, neutral, and negative expressions, after being informed that they are either real or fake. Smiling faces marked as fake appeared less positive, as reflected in expression ratings, and induced slower evaluations. Whereas presumed real smiles elicited canonical emotion effects with differences relative to neutral faces in the P1 and N170 components (markers of early visual perception) and in the EPN component (indicative of reflexive emotional processing), presumed deepfake smiles showed none of these effects. Additionally, only smiles presumed as fake showed enhanced LPP activity compared to neutral faces, suggesting more effortful evaluation. Negative expressions induced typical emotion effects, whether considered real or fake. Our findings demonstrate a dampening effect on perceptual, emotional, and evaluative processing of presumed deepfake smiles, but not angry expressions, adding new specificity to the debate on the societal impact of AI-generated content.

Marine Biomaterials: Hyaluronan.

The marine-derived hyaluronic acid and other natural biopolymers offer exciting possibilities in the field of biomaterials, providing sustainable and biocompatible alternatives to synthetic materials. Their unique properties and abundance in marine sources make them valuable resources for various biomedical and industrial applications. Due to high biocompatible features and participation in biological processes related to tissue healing, hyaluronic acid has become widely used in tissue engineering applications, especially in the wound healing process. The present review enlightens marine hyaluronan biomaterial providing its sources, extraction process, structures, chemical modifications, biological properties, and biocidal applications, especially for wound healing/dressing purposes. Meanwhile, we point out the future development of wound healing/dressing based on hyaluronan and its composites and potential challenges.

The Effects of the Deacetylation of Chitin Nanowhiskers on the Performance of PCL/PLA Bio-Nanocomposites.

The multiple roles of organic nanofillers in biodegradable nanocomposites (NC) with a blend-based matrix is not yet fully understood. This work highlights combination of reinforcing and structure-directing effects of chitin nanowhiskers (CNW) with different degrees of deacetylation (DA), i.e., content of primary or secondary amines on their surface, in the nanocomposite with the PCL/PLA 1:1 matrix. Of importance is the fact that aminolysis with CNW leading to chain scission of both polyesters, especially of PLA, is practically independent of DA. DA also does not influence thermal stability. At the same time, the more marked chain scission/CNW grafting for PLA in comparison to PCL, causing changes in rheological parameters of components and related structural alterations, has crucial effects on mechanical properties in systems with a bicontinuous structure. Favourable combinations of multiple effects of CNW leads to enhanced mechanical performance at low 1% content only, whereas negative effects of structural changes, particularly of changed continuity, may eliminate the reinforcing effects of CNW at higher contents. The explanation of both synergistic and antagonistic effects of structures formed is based on the correspondence of experimental results with respective basic model calculations.

Instant Effects of Semantic Information on Visual Perception.

Does our perception of an object change once we discover what function it serves? We showed human participants (n = 48, 31 females and 17 males) pictures of unfamiliar objects either together with keywords matching their function, leading to semantically informed perception, or together with nonmatching keywords, resulting in uninformed perception. We measured event-related potentials to investigate at which stages in the visual processing hierarchy these two types of object perception differed from one another. We found that semantically informed compared with uninformed perception was associated with larger amplitudes in the N170 component (150-200 ms), reduced amplitudes in the N400 component (400-700 ms), and a late decrease in alpha/beta band power. When the same objects were presented once more without any information, the N400 and event-related power effects persisted, and we also observed enlarged amplitudes in the P1 component (100-150 ms) in response to objects for which semantically informed perception had taken place. Consistent with previous work, this suggests that obtaining semantic information about previously unfamiliar objects alters aspects of their lower-level visual perception (P1 component), higher-level visual perception (N170 component), and semantic processing (N400 component, event-related power). Our study is the first to show that such effects occur instantly after semantic information has been provided for the first time, without requiring extensive learning.SIGNIFICANCE STATEMENT There has been a long-standing debate about whether or not higher-level cognitive capacities, such as semantic knowledge, can influence lower-level perceptual processing in a top-down fashion. Here we could show, for the first time, that information about the function of previously unfamiliar objects immediately influences cortical processing within less than 200 ms. Of note, this influence does not require training or experience with the objects and related semantic information. Therefore, our study is the first to show effects of cognition on perception while ruling out the possibility that prior knowledge merely acts by preactivating or altering stored visual representations. Instead, this knowledge seems to alter perception online, thus providing a compelling case against the impenetrability of perception by cognition.

Beyond speaking: neurocognitive perspectives on language production in social interaction.

The human faculty to speak has evolved, so has been argued, for communicating with others and for engaging in social interactions. Hence the human cognitive system should be equipped to address the demands that social interaction places on the language production system. These demands include the need to coordinate speaking with listening, the need to integrate own (verbal) actions with the interlocutor's actions, and the need to adapt language flexibly to the interlocutor and the social context. In order to meet these demands, core processes of language production are supported by cognitive processes that enable interpersonal coordination and social cognition. To fully understand the cognitive architecture and its neural implementation enabling humans to speak in social interaction, our understanding of how humans produce language needs to be connected to our understanding of how humans gain insights into other people's mental states and coordinate in social interaction. This article reviews theories and neurocognitive experiments that make this connection and can contribute to advancing our understanding of speaking in social interaction. This article is part of a discussion meeting issue 'Face2face: advancing the science of social interaction'.

Separating art from the artist: The effect of negative affective knowledge on ERPs and aesthetic experience.

Some artists do terrible things. But does knowing something bad about an artist affect the way we perceive the work? Despite increased public interest, this question has yet to be addressed empirically. In this pre-registered study, we used aesthetic ratings and electrophysiological brain responses to shed light on the issue. We found that paintings of artists associated with negative-social biographical knowledge were liked less and found more arousing than paintings of artists associated with neutral information. Such paintings also elicited an enhanced brain response associated with fast and reflexive processing of emotional stimuli (early posterior negativity; EPN). Evaluations of quality and later, more controlled brain responses (late positive potential; LPP) were not affected. Reflecting the complexity of aesthetic experience, this pattern of results became more differentiated when the visual relatedness between the contents of the painting and the artist-related information was taken into account. Overall, our findings suggest that emotional aspects involved in art reception are not spontaneously separated from the artist, whilst evaluative judgments and more elaborate processing may be.

Web-based language production experiments: Semantic interference assessment is robust for spoken and typed response modalities.

For experimental research on language production, temporal precision and high quality of the recorded audio files are imperative. These requirements are a considerable challenge if language production is to be investigated online. However, online research has huge potential in terms of efficiency, ecological validity and diversity of study populations in psycholinguistic and related research, also beyond the current situation. Here, we supply confirmatory evidence that language production can be investigated online and that reaction time (RT) distributions and error rates are similar in written naming responses (using the keyboard) and typical overt spoken responses. To assess semantic interference effects in both modalities, we performed two pre-registered experiments (n = 30 each) in online settings using the participants' web browsers. A cumulative semantic interference (CSI) paradigm was employed that required naming several exemplars of semantic categories within a seemingly unrelated sequence of objects. RT is expected to increase linearly for each additional exemplar of a category. In Experiment 1, CSI effects in naming times described in lab-based studies were replicated. In Experiment 2, the responses were typed on participants' computer keyboards, and the first correct key press was used for RT analysis. This novel response assessment yielded a qualitatively similar, very robust CSI effect. Besides technical ease of application, collecting typewritten responses and automatic data preprocessing substantially reduce the work load for language production research. Results of both experiments open new perspectives for research on RT effects in language experiments across a wide range of contexts. JavaScript- and R-based implementations for data collection and processing are available for download.

Experience-driven meaning affects lexical choices during language production.

The role of meaning facets based on sensorimotor experiences is well investigated in comprehension but has received little attention in language production research. In two experiments, we investigated whether experiential traces of space influenced lexical choices when participants completed visually presented sentence fragments (e.g., "You are at the sea and you see a . . .") with spoken nouns (e.g., "dolphin," "palm tree"). The words were presented consecutively in an ascending or descending direction, starting from the centre of the screen. These physical spatial cues did not influence lexical choices. However, the produced nouns met the spatial characteristics of the broader sentence contexts such that the typical spatial locations of the produced noun referents were predicted by the location of the situations described by the sentence fragments (i.e., upper or lower sphere). By including distributional semantic similarity measures derived from computing cosine values between sentence nouns and produced nouns using a web-based text corpus, we show that the meaning dimension of "location in space" guides lexical selection during speaking. We discuss the relation of this spatial meaning dimension to accounts of experientially grounded and usage-based theories of language processing and their combination in hybrid approaches. In doing so, we contribute to a more comprehensive understanding of the many facets of meaning processing during language production and their impact on the words we select to express verbal messages.

Cumulative semantic interference is blind to morphological complexity and originates at the conceptual level.

When naming a sequence of pictures of the same semantic category (e.g., furniture), response latencies systematically increase with each named category member. This cumulative semantic interference effect has become a popular tool to investigate the cognitive architecture of language production. However, not all processes underlying the effect itself are fully understood, including the question where the effect originates from. While some researchers assume the interface of the conceptual and lexical level as its origin, others suggest the conceptual-semantic level. The latter assumption follows from the observation that cumulative effects, namely cumulative facilitation, can also be observed in purely conceptual-semantic tasks. Another unanswered question is whether cumulative interference is affected by the morphological complexity of the experimental targets. In two experiments with the same participants and the same material, we investigated both of these issues. Experiment 1, a continuous picture naming task, investigated whether morphologically complex nouns (e.g., kitchen table) elicit identical levels of cumulative interference to morphologically simple nouns (e.g., table). Our results show this to be the case, indicating that cumulative interference is unaffected by lexical information such as morphological complexity. In Experiment 2, participants classified the same target objects as either man-made or natural. As expected, we observed cumulative facilitation. A separate analysis showed that this facilitation effect can be predicted by the individuals' effect sizes of cumulative interference, suggesting a strong functional link between the two effects. Our results thus point to a conceptual-semantic origin of cumulative semantic interference.

Knowledge-augmented face perception: Prospects for the Bayesian brain-framework to align AI and human vision.

Human visual perception is efficient, flexible and context-sensitive. The Bayesian brain view explains this with probabilistic perceptual inference integrating prior experience and knowledge through top-down influences. Advances in machine learning, such as Artificial Neural Networks (ANNs), have enabled considerable progress in computer vision. Unlike humans, these networks do not yet adaptively draw on meaningful and task-relevant contextual cues and prior knowledge. We propose ideas to better align human and computer vision, applied to facial expression recognition. We review evidence of knowledge-augmented and context-sensitive face perception in humans and approaches trying to leverage such sources of information in computer vision. We discuss how both fields can establish an epistemic loop: Redesigning synthetic systems with inspiration from the Bayesian brain-framework could make networks more flexible and useful for human-machine interaction. In turn, employing ANNs as scientific tools will widen the scope of empirical research into human knowledge-augmented perception.

On the lexical representation(s) of compounds: A continuous picture naming study.

The lexical representation of compound words in speech production is still under debate. While most studies with healthy adult speakers suggest that a single lemma representation is active during compound production, data from neuropsychological studies point toward multiple representations, with activation of the compound's constituent lemmas in addition to the compound's lemma. This study exploits the cumulative semantic interference effect to investigate the lexical representation of compounds in speech production. In a continuous picture naming experiment, category membership was established through the compounds' first constituents (category animals: zebra crossing, pony tail, cat litter …), while the compounds themselves were not semantically related. Moreover, pictures depicting the compounds' first constituents (zebra, pony, cat …) were presented as a control condition. As expected, naming latencies within categories increased linearly with each additionally named category member when producing monomorphemic words, which is interpreted as increasing interference during lexical selection. Importantly, this cumulative semantic interference effect was also observed for compounds. This indicates that the lemmas of the compounds' first constituents were activated during compound production, causing interference due to their semantic relationship and thereby hampering the production of the whole compound. The results are thus in line with the multiple-lemma representation account (Marelli et al., 2012). We argue that the apparent contradiction between results of previous studies with healthy adult speakers and our current study can be explained by the different experimental paradigms used. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Who speaks next? Adaptations to speaker identity in processing spoken sentences.

When listening to a speaker, we need to adapt to her individual speaking characteristics, such as error proneness, accent, etc. The present study investigated two aspects of adaptation to speaker identity during processing spoken sentences in multi-speaker situations: the effect of speaker sequence across sentences and the effect of learning speaker-specific error probability. Spoken sentences were presented, cued, and accompanied by one of three portraits that were labeled as the speakers' faces. In Block 1 speaker-specific probabilities of syntax errors were 10%, 50%, or 90%; in Block 2 they were uniformly 50%. In both blocks, speech errors elicited P600 effects in the scalp recorded ERP. We found a speaker sequence effect only in Block 1: the P600 to target words was larger after speaker switches than after speaker repetitions, independent of sentence correctness. In Block 1, listeners showed higher accuracy in judging sentence correctness spoken by speakers with lower error proportions. No speaker-specific differences in target word P600 and accuracy were found in Block 2. When speakers differ in error proneness, listeners seem to flexibly adapt their speech processing for the upcoming sentence through attention reorientation and resource reallocation if the speaker is about to change, and through proactive maintenance of neural resources if the speaker remains the same.

Electrophysiological Chronometry of Graded Consciousness during the Attentional Blink.

One of the ongoing debates about visual consciousness is whether it can be considered as an all-or-none or a graded phenomenon. While there is increasing evidence for the existence of graded states of conscious awareness based on paradigms such as visual masking, only little and mixed evidence is available for the attentional blink paradigm, specifically in regard to electrophysiological measures. Thereby, the all-or-none pattern reported in some attentional blink studies might have originated from specifics of the experimental design, suggesting the need to examine the generalizability of results. In the present event-related potential (ERP) study (N = 32), visual awareness of T2 face targets was assessed via subjective visibility ratings on a perceptual awareness scale in combination with ERPs time-locked to T2 onset (components P1, N1, N2, and P3). Furthermore, a classification task preceding visibility ratings allowed to track task performance. The behavioral results indicate a graded rather than an all-or-none pattern of visual awareness. Corresponding graded differences in the N1, N2, and P3 components were observed for the comparison of visibility levels. These findings suggest that conscious perception during the attentional blink can occur in a graded fashion.

Internet-based language production research with overt articulation: Proof of concept, challenges, and practical advice.

Language production experiments with overt articulation have thus far only scarcely been conducted online, mostly due to technical difficulties related to measuring voice onset latencies. Especially the poor audiovisual synchrony in web experiments (Bridges et al. 2020) is a challenge to time-locking stimuli and participants' spoken responses. We tested the viability of conducting language production experiments with overt articulation in online settings using the picture-word interference paradigm - a classic task in language production research. In three pre-registered experiments (N = 48 each), participants named object pictures while ignoring visually superimposed distractor words. We implemented a custom voice recording option in two different web experiment builders and recorded naming responses in audio files. From these stimulus-locked audio files, we extracted voice onset latencies offline. In a control task, participants classified the last letter of a picture name as a vowel or consonant via button-press, a task that shows comparable semantic interference effects. We expected slower responses when picture and distractor word were semantically related compared to unrelated, independently of task. This semantic interference effect is robust, but relatively small. It should therefore crucially depend on precise timing. We replicated this effect in an online setting, both for button-press and overt naming responses, providing a proof of concept that naming latency - a key dependent variable in language production research - can be reliably measured in online experiments. We discuss challenges for online language production research and suggestions of how to overcome them. The scripts for the online implementation are made available.

Mental chronometry of speaking in dialogue: Semantic interference turns into facilitation.

Numerous studies demonstrate that the production of words is delayed when speakers process in temporal proximity semantically related words. Yet the experimental settings underlying this effect are different from those under which we typically speak. This study demonstrates that semantic interference disappears, and can even turn into facilitation, when semantically related words are embedded in a meaningful communicative exchange. Experiment 1 and 3 (each N = 32 university students) implemented a picture-word interference task in a game played between two participants: one named the distractor word and, after a stimulus-onset-asynchrony of -150 ms or -650 ms, the other named a semantically related or unrelated target picture. Semantic interference reappeared with identical experimental parameters in a single-person picture-word interference setting (Experiment 2, N = 32). We conclude that the inhibitory context effects leading to semantic interference in single-subject settings are attenuated whereas facilitatory effects are enhanced in communicative settings.