ABSTRACT
Phenolphthalexon, a compound with iminodiacetic acid as a functional group, has been labelled with 113mIn to high chemical purity and its usefulness in studies of biliary excretion patency has been studied. Organ distribution of 113mInphenolphthalexon in mice was characterized by high liver uptake (50.8% of the administered dose after 5 min) and rapid clearance through the gall bladder. An animal model for studying obstruction of biliary excretion has been developed. Data on the kinetics of the radiopharmaceutical were obtained by collecting in-vivo data through an on-line computer.
Subject(s)
Biliary Tract/metabolism , Indium , Liver/metabolism , Phenolphthaleins/metabolism , Radioisotopes , Animals , Cholestasis/diagnostic imaging , Kinetics , Mice , Rabbits , Radionuclide Imaging , Tissue DistributionABSTRACT
The effect of an intrinsic block or extrinsic pressure on blood flow through the inferior vena cava (IVC) was studied after rapid injection of 99mTc-pertechnetate or 99mTc-phytate into the femoral vein. Peak-to-peak transit time (PTT) between the curves generated at IVC origin and over the cardiac blood pool was measured in twelve normal patients (PTT = 2.0 +/- 0.7 s) and six patients clinically suspected of circulatory impediment through the IVC (PTT = 3.0 to 30.0 s). PTT measurements augmented the information obtained from sequential scintiphotos of IVC circulation. It is felt that this may be a more objective parameter for follow-up of patients having a progressive, primary disease of this vessel.
Subject(s)
Technetium/metabolism , Vascular Diseases/diagnostic imaging , Vena Cava, Inferior/diagnostic imaging , Blood Circulation , Computers , Humans , Injections, Intravenous , Methods , Radionuclide Imaging , Technetium/administration & dosage , Time Factors , Vascular Diseases/physiopathology , Vena Cava, Inferior/physiopathologyABSTRACT
A compressed-air nebulizer with low holdup and high output was used to nebulize [99mTc] pertechnetate presented in normal saline. Generated droplets were dried in line and led to an inhalation chamber from which the dry aerosol was inhaled using a nose or mouth inhalation unit. The mass median diameter of the particles was 0.8 microns, with an associated geometric standard deviation of 2.0. The deep lung delivery efficiency--defined as the ratio of the activity deposited in the lung area to the activity nebulized--was found to be reproducible and consistent (15-22%) in all the subjects studied. A 3-5 min inhalation of aerosol, nebulized from 20 mCi, was sufficient to provide a lung image of good information density. No noticeable deposit was seen in the trachea or major brochi. The system is inexpensive, stable in performance, adaptable to other solutions or colloids, and is promising for routine use.
Subject(s)
Lung/diagnostic imaging , Radionuclide Imaging/instrumentation , Technetium/administration & dosage , Aerosols , HumansABSTRACT
A study of some parameters affecting the time activity histogram of an intravenous bolus injection of radioactivity was performed. A scoring system for bolus compactness was attempted. A score of 2 and above was considered to be a satisfactory bolus. Volumes less than 1 ml tended to result in a satisfactory bolus. The nature of the radiopharmaceutical injected, different injecters and age of the patient did not affect the score. Thyrotoxic patients gave the best bolus score.
