[The self-rating of life quality by workers of metal-processing industry].

The cross-sectional study of subjective assessment of quality of life of 300 employees of main professions of metalworking industrial production working in harmful labor environment (classes 3.1-3.4) was carried out using validated Russian version of the WHO QOL-BREF questionnaire. The software Statistica 10 was applied for statistical analysis. The statistical processing of study results was performed by calculating arithmetic mean (M), standard deviation (SD) and presented as M±SD. The non-parametric statistical methods were applied to compare two independent samples: the Mann-Whitney U criterion, the Spearman rank correlation coefficient. The data differences and correlations between the data at p<0.05 were considered statistically significant. Based on the results of analysis, satisfaction of employees with quality of life across all domains was established. The quality of life indicators were independent of gender of respondents. With age and experience, decrease of indicators for all domains was established. High indicators for physical health domain and subjective assessment of health status in examined group can be explained from the standpoint of the "healthy worker effect", but concealment of information about true state of health cannot be ruled out. The metal industry workers working in harmful labor conditions are conditionally healthy and active. There is a need for additional research to obtain objective assessment of their health status.

[The Input of Medical Societies and Zemstvo Physicians into Development of Sanitary Business in the Saratov Gubernia in the Second Half of XIX - Beginning of XX Centuries].

The article presents review of becoming of sanitary business in the Saratov Gubernia, the role of medical community, Zemstvo sanitary bureau in struggling epidemics in XIX - early XX centuries.

Organic waste as a sustainable feedstock for platform chemicals.

Biorefineries have been established since the 1980s for biofuel production, and there has been a switch lately from first to second generation feedstocks in order to avoid the food versus fuel dilemma. To a lesser extent, many opportunities have been investigated for producing chemicals from biomass using by-products of the present biorefineries, simple waste streams. Current facilities apply intensive pre-treatments to deal with single substrate types such as carbohydrates. However, most organic streams such as municipal solid waste or algal blooms present a high complexity and variable mixture of molecules, which makes specific compound production and separation difficult. Here we focus on flexible anaerobic fermentation and hydrothermal processes that can treat complex biomass as a whole to obtain a range of products within an integrated biorefinery concept.

[AntI-inflammatory, antipyretic and antimicrobial activity of flavonoid-containing extract of Gratiola officinalis L].

The extract of Gratiola officinalis L. has been obtained by an original method ensuring the maximum yield of flavonoids. The extract simultaneously exhibits high anti-inflammatory activity, selective antimicrobial properties (with respect to Staphylococcus aureus and Pseudomonas aeruginosa, but not to conditionally pathogenic E. coli) and antipyretic effect (observed for the first time in Gratiola officinalis L. preparations). Advantages of the proposed preparation are low toxicity, availability of the raw material, and broad spectrum of therapeutic effects.

[Typhus fever morbidity among the military personnel and civilians in the regions around Volga river during World War I].

The article is concerned to the materials about epidemiologic situation of typhus fever in the regions around Volga river (Saratovsky, Samarsky and others) during World War I (1914-1918) among the military personnel of the Russian army and among the civilians. The main reasons for spread of infection, ways of the transmission, and also measures for decreasing of level of morbidity on the different stages of evacuation of patients with typhus fever in the safer hospitals are shown. The most important methods of fighting against epidemic of typhus fever were: isolation of patients in separate special hospitals, desincection and disinfection measures in the foci of infection and organization appropriate sanitary conditions for military man in the army and among civilians. Acquired valuable experience of territorial and military doctors during the period of epidemic of typhus fever allowed receiving complex effective antiepidemic measures of fighting and prevention from this disease.

[The contribution of I.I. Molleson in becoming and development of sanitary service in the Saratov guberniia].

The article presents in the historical perspective a brief biography data about I.I. Molleson. The main issues are covered concerning the development of sanitary service in the Saratov guberniya in the end of nineteenth century. The scientific and practical contribution of I.I. Molleson into becoming and development of sanitary business in Russia is demonstrated.

[Chemotherapeutic effect of 3-(5-nitrofuryl)-7-(5-nitrofurfurylidene)-3,3a,4,5,6,7-hexahydro-2H-indazole in experimental staphylococcal infection].

Chemotherapeutic activity of 3-(5-nitrofuryl)-7-(5-nitrofurfuryliden)-3, 3a, 4, 5, 6, 7-hexahydro-2H-indazol (compound 26) was studied on albino mice with experimental staphylococcal infection. The animals were contaminated intraperitoneally. The results of culture of the specimens of the organs of the mice killed within various terms and the values of the spleen bacterial index served as the criteria of the effectiveness. Compound 26 was administered in doses of 20, 10 and 5 mg/kg once a day for 3 days. The treatment was started simultaneously with or 24 hours after the contamination. The results showed that compound 26 in a dose 20 mg/kg (0.4 mg/mouse) possessed high chemotherapeutic activity in experimental staphylococcal infection of albino mice and could be recommended for a thorough study as a potential agent for chemotherapy of staphylococcal infection.

[Antimicrobial activity of new original 2-aryliden-6-furfuryliden cyclohexanones and hexahydroindazoles on their basis]. / Antimikrobnaia aktivnost' novykh original'nykh 2-ariliden-6-furfurilidentsiklogeksanonov i geksagidroindroindazolov na ikh isnove.

Antimicrobial activity of 25 new original 2-aryliden-6-furfuryliden cyclohexanones and hexahydroindazoles based on them was studied. The majority of the compounds had low or moderate activity against the test cultures of Staphylococcus spp., Pseudomonas aeruginosa, Proteus spp. and Escherichia coil. Compound XIX (2,3-diphenyl-7-(5-nitrofurfuryliden)-3,3a,4,5,6,7-hexahydroindazole) with high antistaphylococcal activity was selected among several 2-aryliden-6-furfuryliden cyclohexanones and hexahydroindazoles. The activity of compound XIX was tested with the use of 105 clinical isolates of staphylococci. Comparative antistaphylococcal activity of compound XIX, furazolidone and sodium cefotaxime against the isolates was estimated. The impact of the microbial load, pH of the nutrient medium and the presence of 1%, 5% or 10% of serum or blood in the medium on the antimicrobial activity of compound XIX was evaluated. The results are in favour of further research on compound XIX as a potential agent of etiotropic therapy for staphylococcal infection.