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J Biol Chem ; 280(23): 22036-43, 2005 Jun 10.
Article in English | MEDLINE | ID: mdl-15809292

ABSTRACT

The mitochondrial carrier family transports a variety of metabolites across the inner mitochondrial membrane. We identified and cloned a new member of this family, KMCP1 (kidney mitochondrial carrier protein-1), that is highly homologous to the previously identified protein BMCP1 (brain mitochondrial carrier protein-1). Western blotting and in situ experiments showed that this carrier is expressed predominantly within the kidney cortex in the proximal and distal tubules. KMCP1 was increased during fasting and during the regenerative phase of glycerol-induced renal failure. We show that both situations are associated with transiently increased expression of superoxide-generating enzymes, followed by increased mitochondrial metabolism and antioxidant defenses. Given that KMCP1 expression occurs simultaneously with these latter events, we propose that KMCP1 is involved in situations in which mitochondrial metabolism is increased, in particular when the cellular redox balance tends toward a pro-oxidant status.


Subject(s)
Antioxidants/pharmacology , Carrier Proteins/biosynthesis , Carrier Proteins/chemistry , Carrier Proteins/physiology , Kidney Tubules/physiology , Kidney/metabolism , Mitochondria/metabolism , Mitochondrial Proteins/biosynthesis , Mitochondrial Proteins/physiology , Regeneration , Up-Regulation , Amino Acid Sequence , Animals , Blotting, Northern , Blotting, Western , Brain/metabolism , COS Cells , Carrier Proteins/metabolism , Cloning, Molecular , DNA, Complementary/metabolism , Glutamine/chemistry , Glycerol/chemistry , Glycerol/metabolism , Immunoprecipitation , Ion Channels , Membrane Potentials , Membrane Proteins/metabolism , Mice , Mice, Inbred C57BL , Molecular Sequence Data , Oxidants/pharmacology , Oxidation-Reduction , Oxidative Stress , Oxygen/metabolism , Oxygen Consumption , Phylogeny , RNA/chemistry , RNA/metabolism , Superoxide Dismutase/metabolism , Time Factors , Tissue Distribution , Uncoupling Protein 1
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