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1.
J Nucl Cardiol ; 28(4): 1596-1607, 2021 08.
Article in English | MEDLINE | ID: mdl-31529385

ABSTRACT

BACKGROUND: Psychosocial stress is recognized as a risk factor for coronary heart disease (CHD). High rates of CHD in African-Americans may be related to psychosocial stress. However, standard cardiac rehabilitation (CR) usually does not include a systematic stress-reduction technique. Previous studies suggest that the Transcendental Meditation (TM) technique may reduce CHD risk factors and clinical events. This pilot study explored the effects of standard CR with and without TM on a measure of CHD in African-American patients. METHODS: Fifty-six CHD patients were assigned to CR, CR + TM, TM alone, or usual care. Testing was done at baseline and after 12 weeks. The primary outcome was myocardial flow reserve (MFR) assessed by 13N-ammonia positron emission tomography (PET). Secondary outcomes were CHD risk factors. Based on guidelines for analysis of small pilot studies, data were analyzed for effect size (ES). RESULTS: For 37 patients who completed posttesting, there were MFR improvements in the CR + TM group (+20.7%; ES = 0.64) and the TM group alone (+12.8%; ES = 0.36). By comparison, the CR-alone and usual care groups showed modest changes (+ 5.8%; ES = 0.17 and - 10.3%; ES = - 0.31), respectively. For the combined TM group, MFR increased (+ 14%, ES = 0.56) compared to the combined non-TM group (- 2.0%, ES = - 0.08). CONCLUSIONS: These pilot data suggest that adding the TM technique to standard cardiac rehabilitation or using TM alone may improve the myocardial flow reserve in African-American CHD patients. These results may be applied to the design of controlled clinical trials to definitively test these effects. TRIAL REGISTRATION: ClinicalTrials.gov registration # NCT01810029.


Subject(s)
Black or African American , Cardiac Rehabilitation , Coronary Disease/physiopathology , Coronary Disease/rehabilitation , Fractional Flow Reserve, Myocardial/physiology , Meditation , Aged , Coronary Disease/diagnostic imaging , Female , Humans , Male , Middle Aged , Pilot Projects , Positron-Emission Tomography , Stress, Psychological/ethnology , Stress, Psychological/prevention & control
2.
Circ Cardiovasc Qual Outcomes ; 5(6): 750-8, 2012 Nov.
Article in English | MEDLINE | ID: mdl-23149426

ABSTRACT

BACKGROUND: Blacks have disproportionately high rates of cardiovascular disease. Psychosocial stress may contribute to this disparity. Previous trials on stress reduction with the Transcendental Meditation (TM) program have reported improvements in cardiovascular disease risk factors, surrogate end points, and mortality in blacks and other populations. METHODS AND RESULTS: This was a randomized, controlled trial of 201 black men and women with coronary heart disease who were randomized to the TM program or health education. The primary end point was the composite of all-cause mortality, myocardial infarction, or stroke. Secondary end points included the composite of cardiovascular mortality, revascularizations, and cardiovascular hospitalizations; blood pressure; psychosocial stress factors; and lifestyle behaviors. During an average follow-up of 5.4 years, there was a 48% risk reduction in the primary end point in the TM group (hazard ratio, 0.52; 95% confidence interval, 0.29-0.92; P=0.025). The TM group also showed a 24% risk reduction in the secondary end point (hazard ratio, 0.76; 95% confidence interval, 0.51-0.1.13; P=0.17). There were reductions of 4.9 mmHg in systolic blood pressure (95% confidence interval -8.3 to -1.5 mmHg; P=0.01) and anger expression (P<0.05 for all scales). Adherence was associated with survival. CONCLUSIONS: A selected mind-body intervention, the TM program, significantly reduced risk for mortality, myocardial infarction, and stroke in coronary heart disease patients. These changes were associated with lower blood pressure and psychosocial stress factors. Therefore, this practice may be clinically useful in the secondary prevention of cardiovascular disease. Clinical Trial Registration- URL: www.clinicaltrials.gov Unique identifier: NCT01299935.


Subject(s)
Black or African American/psychology , Coronary Disease/therapy , Health Knowledge, Attitudes, Practice/ethnology , Meditation , Myocardial Infarction/prevention & control , Patient Education as Topic , Secondary Prevention/methods , Stress, Psychological/therapy , Stroke/prevention & control , Aged , Coronary Disease/ethnology , Coronary Disease/mortality , Coronary Disease/psychology , Female , Hospitalization , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Multivariate Analysis , Myocardial Infarction/ethnology , Myocardial Infarction/mortality , Myocardial Infarction/psychology , Proportional Hazards Models , Risk Assessment , Risk Factors , Stress, Psychological/ethnology , Stress, Psychological/mortality , Stress, Psychological/psychology , Stroke/ethnology , Stroke/mortality , Stroke/psychology , Time Factors , Treatment Outcome , Wisconsin/epidemiology
3.
Integr Cancer Ther ; 8(3): 228-34, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19815592

ABSTRACT

UNLABELLED: This single-blind, randomized controlled trial evaluated the impact of the Transcendental Meditation program plus standard care as compared with standard care alone on the quality of life (QOL) of older women (>or=55 years) with stage II to IV breast cancer. One hundred and thirty women (mean age = 63.8) were randomly assigned to either experimental (n = 64) or control (n = 66) groups. Functional Assessment of Cancer Therapy-Breast (FACT-B), Functional Assessment of Chronic Illness Therapy- Spiritual Well-Being (FACIT-SP), and Short-Form (SF)-36 mental health and vitality scales were administered every 6 months over an average 18-month intervention period. Significant improvements were found in the Transcendental Meditation group compared with controls in overall QOL, measured by the FACT-B total score (P = .037), emotional well-being (P = .046), and social well-being (P = .003) subscales, and SF-36 mental health ( P = .017). RESULTS: It is recommended that this stress reduction program, with its ease of implementation and home practice, be adopted in public health programs.


Subject(s)
Breast Neoplasms/psychology , Breast Neoplasms/therapy , Meditation/psychology , Quality of Life/psychology , Aged , Breast Neoplasms/mortality , Female , Humans , Middle Aged , Neoplasm Staging , Patient Compliance/statistics & numerical data , Sample Size , Single-Blind Method , Stress, Psychological/psychology , Stress, Psychological/therapy , Surveys and Questionnaires , Treatment Outcome
4.
Am J Hypertens ; 22(12): 1326-31, 2009 Dec.
Article in English | MEDLINE | ID: mdl-19798037

ABSTRACT

BACKGROUND: Psychological distress contributes to the development of hypertension in young adults. This trial assessed the effects of a mind-body intervention on blood pressure (BP), psychological distress, and coping in college students. METHODS: This was a randomized controlled trial (RCT) of 298 university students randomly allocated to either the Transcendental Meditation (TM) program or wait-list control. At baseline and after 3 months, BP, psychological distress, and coping ability were assessed. A subgroup of 159 subjects at risk for hypertension was analyzed similarly. RESULTS: Changes in systolic BP (SBP)/diastolic BP (DBP) for the overall sample were -2.0/-1.2 mm Hg for the TM group compared to +0.4/+0.5 mm Hg for controls (P = 0.15, P = 0.15, respectively). Changes in SBP/DBP for the hypertension risk subgroup were -5.0/-2.8 mm Hg for the TM group compared to +1.3/+1.2 mm Hg for controls (P = 0.014, P = 0.028, respectively). Significant improvements were found in total psychological distress, anxiety, depression, anger/hostility, and coping (P values < 0.05). Changes in psychological distress and coping correlated with changes in SBP (P values < 0.05) and DBP (P values < 0.08). CONCLUSIONS: This is the first RCT to demonstrate that a selected mind-body intervention, the TM program, decreased BP in association with decreased psychological distress, and increased coping in young adults at risk for hypertension. This mind-body program may reduce the risk for future development of hypertension in young adults.


Subject(s)
Adaptation, Psychological/physiology , Blood Pressure/physiology , Meditation , Stress, Psychological/therapy , Adolescent , Adult , Blood Pressure/drug effects , Female , Humans , Male , Relaxation Therapy , Single-Blind Method , Treatment Outcome
5.
Curr Hypertens Rep ; 9(6): 520-8, 2007 Dec.
Article in English | MEDLINE | ID: mdl-18350109

ABSTRACT

Substantial evidence indicates that psychosocial stress contributes to hypertension and cardiovascular disease (CVD). Previous meta-analyses of stress reduction and high blood pressure (BP) were outdated and/or methodologically limited. Therefore, we conducted an updated systematic review of the published literature and identified 107 studies on stress reduction and BP. Seventeen trials with 23 treatment comparisons and 960 participants with elevated BP met criteria for well-designed randomized controlled trials and were replicated within intervention categories. Meta-analysis was used to calculate BP changes for biofeedback, -0.8/-2.0 mm Hg (P = NS); relaxation-assisted biofeedback, +4.3/+2.4 mm Hg (P = NS); progressive muscle relaxation, -1.9/-1.4 mm Hg (P = NS); stress management training, -2.3/-1.3 mm (P = NS); and the Transcendental Meditation program, -5.0/-2.8 mm Hg (P = 0.002/0.02). Available evidence indicates that among stress reduction approaches, the Transcendental Meditation program is associated with significant reductions in BP. Related data suggest improvements in other CVD risk factors and clinical outcomes.


Subject(s)
Hypertension/prevention & control , Stress, Psychological/prevention & control , Biofeedback, Psychology , Blood Pressure , Cardiovascular Diseases/prevention & control , Cardiovascular Diseases/psychology , Evidence-Based Medicine , Humans , Hypertension/psychology , Meditation
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