ABSTRACT
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Though the cardinal features of PD are motor symptoms, it is also associated with many non-motor symptoms, such as cognitive impairment, autonomic dysfunction, sleep disorders, and depression, which could affect the quality of life. Early identification of PD's non-motor signs can aid in the diagnosis of PD. The current research aimed to assess the neurophysiological changes in PD patients using auditory evoked P300 potential and to determine the possible correlation between P300 wave components and cognitive impairment. MATERIALS AND METHODS: This cross-sectional research involved 32 idiopathic PD patients. The neurophysiological changes in PD patients were studied using auditory evoked P300 potential and the obtained data were compared with normative data. The patient's cognitive status was scored using the Montreal Cognitive Assessment (MoCA) questionnaire and they were divided into two groups: the patients with normal cognition and the patients with impaired cognition. RESULTS: The participants showed a significant decrease in P300 amplitude (p = 0.000) but no change in P300 latency when compared to normative data using the Wilcoxon rank sum test. Also, there was a positive correlation between the MoCA score and P300 amplitude (p < 0.05), indicating that if cognition is impaired, P300 amplitude would also be reduced. There was a significant difference between PD patients with impaired cognition and patients with normal cognition in the P300 amplitude at Cz (p = 0.001) and Fz (p = 0.003) when the Mann-Whitney U test was used. These findings indicate that it is possible to notice changes in the P300 wave components among PD patients when their cognition is impaired. CONCLUSION: Auditory evoked P300 potentials can be used to objectively evaluate cognition in PD patients and by starting supportive therapy, the quality of life for PD patients can be improved.
ABSTRACT
PURPOSE: The purpose of the study was to compare delayed and early loaded single-tooth implant technique. MATERIALS AND METHODS: A randomized, prospective clinical trial was conducted to evaluate the clinical and radiological parameters of delayed and early loading of single-tooth implant placement. Fourteen male or female patients were selected randomly, who had single tooth missing in mandibular posterior region. A delayed implant placement technique was followed in these regions. A Hi-Tech implant (Life Care Implants) was performed. The patients were divided into two groups: delayed loading group and early loading group. In delayed loading groups, implants were loaded after 3 months, and in early loading groups, implants were loaded within 7 days to 2 months. Soft tissue and radiological bone loss were assessed at baseline, 3 months, and 6 months. The parameters assessed were plaque index, gingival index, probing pocket depth, thickness of peri-implant mucosa, and bone loss (radiographically). RESULTS: The results show that there was no statistical difference in indexes taken between delayed loading and early loading groups. CONCLUSION: In this study, after first 6 months there was no difference in success rate between delayed loading or early loading of implants. This study also showed that more bone loss occurred around delayed loading implants. So it can be concluded that early loading technique can be successfully practiced instead of delayed loading of implants.
ABSTRACT
Punica granatum (pomegranate), the member of Punicaceae family, is used in the prevention and treatment of health disorders. P. granatum contains diverse range of phytochemicals including ellagic acid, punicalagin, pedunculagin, quercetin, rutin, tannic acid, polyphenol, anthocyanins, and catechins. This review aims at providing an overview of the chemical constituents, antibacterial, anti-inflammatory, and antioxidant properties of P. granatum, and its role in the prevention and treatment of gingival and periodontal diseases.
