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Postgrad Med J ; 54(628): 108-12, 1978 Feb.
Article in English | MEDLINE | ID: mdl-273209

ABSTRACT

Three patients with aplastic anaemia following chloroquine therapy are described. In two, chloroquine had been administered in large doses over a long period. One of them subsequently developed acute myeloblastic leukaemia. The third received only a small dose and pancytopenia with aplasia followed three weeks after ingestion of the drug. The mechanism(s) of chloroquine-induced marrow injury is not known. A parallel to chloramphenicol-induced blood dyscrasias is drawn, but remains unproved.


Subject(s)
Anemia, Aplastic/chemically induced , Chloroquine/adverse effects , Leukemia, Myeloid, Acute/chemically induced , Adult , Bone Marrow/pathology , Chloroquine/therapeutic use , Female , Humans , Malaria/drug therapy , Male , Middle Aged
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