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1.
Ophthalmic Plast Reconstr Surg ; 26(5): 385-6, 2010.
Article in English | MEDLINE | ID: mdl-20639785

ABSTRACT

A 70-year-old Indian female presented with a lobulated, violet-colored mass in the left eye involving the medial bulbar conjunctiva and caruncle. It was smooth, vascular, compressible, and freely mobile. It was neither reducible nor pulsatile and did not cause any proptosis or dystopia. Any syndromic associations and orbital extension of the lesion were ruled out. Excisional biopsy was performed, and histopathologic examination confirmed the diagnosis of cavernous hemangioma of conjunctiva involving the caruncle.


Subject(s)
Conjunctival Neoplasms/pathology , Hemangioma, Cavernous/pathology , Aged , Conjunctival Neoplasms/surgery , Female , Hemangioma, Cavernous/surgery , Humans
3.
Ir Med J ; 94(4): 114-7, 2001 Apr.
Article in English | MEDLINE | ID: mdl-11440047

ABSTRACT

Our aims were to determine the incidence of gallstones in a cohort of patients infected with hepatitis C for 20 years, and to analyse the outcome of all patients infected with hepatitis C undergoing laparoscopic cholecystectomy. A hepatitis C screening programme in place in Ireland since 1994 identified 965 patients with hepatitis C antibodies out of 62,667 patients screened. The hepatology unit of Cork University Hospital has 318 patients with hepatitis C. Of patients identified by screening, 201 were post partum women infected via contaminated Anti-D immunoglobulin administered in 1977. Thirty-five (17.4%) of two hundred and one patients with hepatitis C since 1977 had developed gallstones after twenty years. A total of 34 patients with hepatitis C underwent laparoscopic cholecystectomy. One patient required conversion to open cholecystectomy. There were no complications and no mortality. There was a low rate of cirrhosis (11%) on examining liver histology. The incidence of gallstones in a cohort of patients infected with hepatitis C for twenty years approximates to that of the general population. The low rate of cirrhosis in this group may be related to a low consumption of alcohol. Laparoscopic cholecystectomy is a safe procedure in patients with mild chronic liver disease caused by hepatitis C.


Subject(s)
Cholecystectomy, Laparoscopic , Cholelithiasis/epidemiology , Hepatitis C, Chronic/epidemiology , Cholelithiasis/surgery , Cohort Studies , Drug Contamination , Female , Hepatitis C, Chronic/etiology , Humans , Incidence , Isoantibodies/administration & dosage , Isoantibodies/adverse effects , Male , Rho(D) Immune Globulin , Time Factors , Treatment Outcome
4.
Br J Surg ; 86(12): 1538X-1542, 1999 Dec.
Article in English | MEDLINE | ID: mdl-10594502

ABSTRACT

BACKGROUND: This study was designed to determine whether Helicobacter pylori forms part of the normal microenvironment of the appendix, whether it plays a role in the pathogenesis of acute appendicitis, and whether it is associated with increased expression of inducible nitric oxide synthetase (iNOS) in appendicular macrophages. METHODS: Serology for H. pylori was performed on 51 consecutive patients undergoing emergency appendicectomy. Appendix samples were tested for urease activity, cultured and stained for H. pylori, graded according to the degree of inflammatory infiltrate, and probed immunohistochemically for iNOS expression. RESULTS: The mean age of the patients was 21 (range 7-51) years. Seventeen patients (33 per cent) were seropositive for H. pylori but no evidence of H. pylori was found in any appendix specimen. However, an enhanced inflammatory cell infiltration was observed in seropositive patients (P < 0.04) and the expression of macrophage iNOS in the mucosa of normal and inflamed appendix specimens was increased (P < 0.01). CONCLUSION: H. pylori does not colonize the appendix and is unlikely to be a pathogenic stimulus for appendicitis. Priming effects on mucosal immunology downstream from the foregut may occur after infection with H. pylori.


Subject(s)
Appendectomy , Appendicitis/enzymology , Helicobacter Infections/enzymology , Helicobacter pylori , Nitric Oxide Synthase/metabolism , Adolescent , Adult , Appendicitis/microbiology , Child , Emergencies , Enzyme-Linked Immunosorbent Assay , Helicobacter Infections/complications , Humans , Immunohistochemistry , Macrophages/enzymology , Middle Aged , Nitric Oxide Synthase Type II
5.
Br J Surg ; 86(12): 1538-1542, 1999 Dec.
Article in English | MEDLINE | ID: mdl-10632658

ABSTRACT

BACKGROUND: This study was designed to determine whether Helicobacter pylori forms part of the normal microenvironment of the appendix, whether it plays a role in the pathogenesis of acute appendicitis, and whether it is associated with increased expression of inducible nitric oxide synthetase (iNOS) in appendicular macrophages. METHODS: Serology for H. pylori was performed on 51 consecutive patients undergoing emergency appendicectomy. Appendix samples were tested for urease activity, cultured and stained for H. pylori, graded according to the degree of inflammatory infiltrate, and probed immunohistochemically for iNOS expression. RESULTS: The mean age of the patients was 21 (range 7-51) years. Seventeen patients (33 per cent) were seropositive for H. pylori but no evidence of H. pylori was found in any appendix specimen. However, an enhanced inflammatory cell infiltration was observed in seropositive patients (P < 0.04) and the expression of macrophage iNOS in the mucosa of normal and inflamed appendix specimens was increased (P < 0.01). CONCLUSION: H. pylori does not colonize the appendix and is unlikely to be a pathogenic stimulus for appendicitis. Priming effects on mucosal immunology downstream from the foregut may occur after infection with H. pylori.

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