Subject(s)
Gases , Hepatic Veins/diagnostic imaging , Liver Transplantation , Female , Humans , Middle Aged , Postoperative Care , UltrasonographyABSTRACT
Hepatic hamartomas were thought to be a rare finding in patients with tuberous sclerosis. The purpose of this study was to assess their incidence in children with tuberous sclerosis and to review the literature. During 1984-90 we examined 51 children by ultrasonography; there were 25 boys and 26 girls. Their age ranged from 3 months to 18 years. Liver hamartomas were seen in 12 (23.5%) of the children, more often in girls than boys (5:1). Their incidence increased with age reaching 45% in children over the age of 10. They did not produce any symptoms of hepatic dysfunction. Our study and review of reported cases prove that hepatic hamartomas are a common finding in patients with tuberous sclerosis and may be very helpful in providing a more accurate diagnosis and consequently help in genetic counselling.
Subject(s)
Hamartoma/epidemiology , Liver Neoplasms/epidemiology , Tuberous Sclerosis/complications , Adolescent , Adult , Child , Child, Preschool , Female , Hamartoma/complications , Hamartoma/diagnostic imaging , Humans , Incidence , Infant , Liver/diagnostic imaging , Liver Neoplasms/complications , Liver Neoplasms/diagnostic imaging , Male , UltrasonographySubject(s)
Hamartoma/etiology , Liver Neoplasms/etiology , Tuberous Sclerosis/complications , Adolescent , Age Factors , Child , Child, Preschool , Female , Humans , Infant , MaleABSTRACT
The effect of repeated ischemic episodes to experimental liver tumors is studied in a group of inbred Wistar-Furth rats. A vascular occluder model was developed specially for the purpose of delivering intermittent compressions to the hepatic artery in the rat. With five daily 1-hr occlusions of the hepatic artery, rats benefited from significantly reduced tumor growth rates compared with controls that underwent sham operation (P less than 0.05). In contrast to results from previous pig experiments, it is demonstrated by angiographic studies that repeated transient dearterialization does not entirely overcome the problem of collateral vessel formation in the rat. Tumor neovascularization continues irrespective of whether the tumor is being dearterialized. It is also observed that in both normal and tumor rats, collateral channels from the left gastric artery temporarily open up when the hepatic artery is obstructed but disappear on reestablishment of flow. As such types of collateral flow are beyond our control, it is imperative that future developments in vascular occlusion therapy should aim at shortening ischemia time and combining with chemotherapy.
Subject(s)
Adenocarcinoma/therapy , Hepatic Artery , Liver Neoplasms/therapy , Adenocarcinoma/pathology , Adenocarcinoma/physiopathology , Angiography , Animals , Collateral Circulation , Constriction/instrumentation , Constriction/methods , Equipment Design , Hepatic Artery/diagnostic imaging , Hepatic Artery/physiopathology , Liver Neoplasms/pathology , Liver Neoplasms/physiopathology , Neoplasm Transplantation , Rats , Rats, Inbred Strains , Rats, Inbred WFABSTRACT
In 53 patients comparison was made between findings at autopsy and findings at ultrasound (US) examination performed shortly before death as the only morphologic diagnostic procedure of the liver during the patient's last year. US was found to be highly accurate. The non-invasiveness and the possibility of examining the patient in bed make US examination in experienced hands the ideal initial diagnostic procedure, especially in terminally ill patients.
Subject(s)
Liver Diseases/diagnosis , Ultrasonography , Adult , Aged , Autopsy , Female , Humans , Liver/pathology , Liver Diseases/pathology , Male , Middle Aged , Retrospective StudiesABSTRACT
A five-year-old girl with portal vein thrombosis and severe gastrointestinal hemorrhage recurring after repeated endoscopic sclerotherapy was successfully embolized via an ultrasonically guided transsplenic catheterization of the splenic vein.
