Subject(s)
Epithelioid Cells/pathology , Keratins/metabolism , Pleural Neoplasms/metabolism , Pleural Neoplasms/pathology , Solitary Fibrous Tumors/metabolism , Solitary Fibrous Tumors/pathology , Epithelioid Cells/metabolism , Humans , Male , Middle Aged , Pleural Neoplasms/diagnosis , Solitary Fibrous Tumors/diagnosisSubject(s)
Cystadenocarcinoma, Mucinous/pathology , Testicular Neoplasms/pathology , Cystadenocarcinoma, Mucinous/metabolism , Diagnosis, Differential , Humans , Immunohistochemistry , Keratins/metabolism , Male , Middle Aged , Mucin 5AC , Mucin-2 , Mucins/metabolism , Testicular Neoplasms/metabolismABSTRACT
Neoadjuvant chemotherapy has become an integral part of the treatment for locally advanced breast cancer. It facilitates tumor resectability and also provides an opportunity for the assessment of therapeutic response and prognosis. We report a case in which a large primary breast carcinoma was significantly reduced in size clinically and replaced by a mass lesion that was composed almost entirely of foamy histiocytes. This peculiar phenomenon is described in detail, together with a brief review of the other known postchemotherapy histologic features that include tumor necrosis, tumor cell cytoplasmic vacuolation and marked nuclear atypia, accompanying chronic inflammatory cellular infiltrate, fibrosis, and ductal-lobular atrophy.
Subject(s)
Breast Diseases/chemically induced , Breast Neoplasms/drug therapy , Carcinoma, Ductal, Breast/drug therapy , Xanthomatosis/chemically induced , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Carcinoma, Ductal, Breast/radiotherapy , Carcinoma, Ductal, Breast/surgery , Cyclophosphamide/administration & dosage , Diagnosis, Differential , Doxorubicin/administration & dosage , Female , Foam Cells/pathology , Histiocytes/pathology , Humans , Middle Aged , Neoplasm, Residual/diagnosis , Xanthomatosis/diagnosisABSTRACT
Leiomyosarcoma of the adrenal gland is a very rare tumour. We report a case of this rare tumour and review the previous case reports. The patient, a 68-year-old woman, presented with a 1-week history of right loin pain and fever associated with loss of weight and appetite. Computerised tomography and ultrasound scans showed the presence of a right adrenal gland tumour, which was subsequently surgically removed. Histological examination of the 12.5-cm tumour revealed a leiomyosarcoma of the adrenal gland. The patient was alive and well with no evidence of recurrent disease 1 year later.