A grid-wise approach for accurate computation of Standardized Runoff Index (SRI).

The Standardized Runoff Index (SRI) is a major indicator for evaluating hydrological drought conditions, accomplished by comparing the current runoff data with retrospective runoff conditions of an area for the same period. This hydrological drought indicator facilitates the characterisation of runoff variations across diverse regions. This study introduces a refined methodology for accurate computation of SRI by employing a grid-wise approach. Distinct probability distributions were fitted to each grid within the study area, diverging from the conventional practice of using a single probability distribution for the entire basin or sub-basin. The research endeavours to assess the efficacy of the grid-wise approach in improving the representation of drought characteristics when compared to the traditional areal approach. A comparative analysis between the performances of SRI computed through grid-wise fitting (where the probability distribution dynamically adapts to each grid) and the areal fitting approach (employing a uniform distribution across all grids) was conducted within the Godavari Basin, India. The findings in this study underscore that the misrepresentation of extreme events is inevitable for large heterogeneous basins like Godavari when the traditional areal approach was employed for SRI computation. Consequently, the grid-wise fitting emerges as a more accurate method for computing the SRI, particularly in characterising extreme dry or wet events.

A Clinico-Mycological and Histopathological Study of Recurrent Dermatophytosis.

Background: A few recent studies have shown fungal elements within the hair follicle epithelium, which may act as a reservoir and responsible for recurrent dermatophytosis. Objectives: To assess the clinical patterns, mycological profile, and histopathology of recurrent dermatophytosis and to determine the prevalence of fungal hyphae in the hair follicle epithelium and other appendages. Materials and Methods: One hundred and fifty clinically diagnosed cases of recurrent dermatophytic infection were included. Skin samples were taken for direct microscopy, fungal culture, and histopathological analysis. Haematoxylin and eosin and special staining with periodic acid Schiff (PAS) and Gomori's methenamine silver (GMS) were performed to detect the fungal hyphae in the skin and hair follicle epithelium. Results: The most common clinical pattern observed was tinea corporis et cruris in 64 patients (42.66%). On direct microscopy and fungal culture, positive results were obtained in 116 cases (77.33%) and 78 (52%) cases, respectively. Presence of fungal hyphae in the stratum corneum, hair follicle, and acrosyringium was seen in 107 patients (71.33%), 47 patients (31.33%), and five patients (3.33%), respectively. Out of the 52 cases with hair follicle and eccrine gland involvement, history of fixed drug combinations (FDC) cream use was present in 42 cases (80.76%) and absent in ten cases (19.24%) (P = 0.000062). Limitations: Skin samples were taken only from a single skin lesion. Higher incidence of follicular invasion may have been detected if multiple biopsy samples were taken. Conclusion: Hair follicle/eccrine sweat gland involvement was observed in nearly one-third of the patients, which may act as a reservoir and may be responsible for recurrence and chronicity. Histopathology should be considered as an important adjuvant tool in recurrent dermatophytosis to establish the extent of the infection, which guides the further management.

Effect of association of temperature and pollutant levels on COVID-19 spread over Jaipur.

The association of temperature and air pollutants is a very prominent factor which significantly affects human health and may cause diseases such as respiratory illness, cardiovascular mortality in spreading of different pathogenic diseases. The pandemic due to covid-19 infection may be affected by temperature and concentration of pollutants. Jaipur is one of the most polluted cities in Rajasthan of India as per World Health Organization, 2016; also, Jaipur city has a hot semi-arid climate with extremely hot summers. This fact tempered us to examine the impact of the association of temperature and pollutants on corona-virus infection in humans over Jaipur. Analysis was conducted by correlating air pollutants (PM10, PM2.5, NO2, SO2, CO) on seasonal variations because the temperature is one of the major factors in changing seasons. Association between the number of Covid cases and temperature in Jaipur was observed during December 2019 to December 2020. Seasonal analysis indicated that the intensity of Covid-19 infection varied according to increase or decrease in temperature.

A Clinico-mycological, Antifungal Drug Sensitivity and Therapeutic Study of Extensive Dermatophytosis in Coastal Andhra Pradesh.

Background: In India, an increased prevalence of chronic, recurrent, and recalcitrant dermatophytosis is being observed. The present study assesses the clinico-mycological profile, antifungal drug sensitivity and therapeutic efficacy of various systemic antifungal drug regimens, in extensive dermatophytosis patients of coastal Andhra Pradesh. Materials and Methods: One hundred and fifty clinically diagnosed cases of extensive dermatophytosis affecting more than one body region were enrolled. Skin samples were taken for direct microscopy and fungal culture. Antifungal drug sensitivity testing was done with broth microdilution test. Therapeutic efficacy of systemic antifungal drug regimens was determined by randomly dividing the patients into 5 groups of 30 each. Results: The most common clinical patterns observed were tinea corporis et cruris (62.7%) followed by extensive tinea corporis (11.3%). KOH and culture positivity were seen in 132 (88%) and 84 cases (56%) respectively. Trichophyton mentagrophytes was isolated in 78 cases (92.8%) followed by Microsporum gypseum in 6 patients (7.1%). The overall mean minimum inhibitory concentration values for itraconazole (0.04 µg/mL) were low when compared to griseofulvin (4.61 µg/mL) and terbinafine (6.9 µg/mL) (P < 0.05). Combination of itraconazole and griseofulvin achieved highest clinical and mycological cure rates (93.1%). Among patients receiving single drugs, itraconazole had higher cure rates (71.4%) compared to terbinafine (59.2%) and griseofulvin (53.8%) (P < 0.05). Conclusion: Trichophyton mentagrophytes has replaced Trichophyton rubrum as the predominant species causing dermatophytosis in Andhra Pradesh, presenting with a severe phenotype. Itraconazole was found to be the most effective drug both in vivo and in vitro. A combination of systemic drugs should be considered in cases of monotherapy failure and in recalcitrant dermatophytosis.

Optimization of physical schemes in WRF model on cyclone simulations over Bay of Bengal using one-way ANOVA and Tukey's test.

Evaluation of appropriate physics parameterization schemes for the Weather Research and Forecasting (WRF) model is vital for accurately forecasting tropical cyclones. Three cyclones Nargis, Titli and Fani have been chosen to investigate the combination of five cloud microphysics (MP), three cumulus convection (CC), and two planetary boundary layer (PBL) schemes of the WRF model (ver. 4.0) with ARW core with respect to track and intensity to determine an optimal combination of these physical schemes. The initial and boundary conditions for sensitivity experiments are drawn from the National Centers for Environmental Prediction (NCEP) global forecasting system (GFS) data. Simulated track and intensity of three cyclonic cases are compared with the India Meteorological Department (IMD) observations. One-way analysis of variance (ANOVA) is applied to check the significance of the data obtained from the model. Further, Tukey's test is applied for post-hoc analysis in order to identify the cluster of treatments close to IMD observations for all three cyclones. Results are obtained through the statistical analysis; average root means square error (RMSE) of intensity throughout the cyclone period and time error at landfall with the step-by-step elimination method. Through the elimination method, the optimal scheme combination is obtained. The YSU planetary boundary layer with Kain-Fritsch cumulus convection and Ferrier microphysics scheme combination is identified as an optimal combination in this study for the forecasting of tropical cyclones over the Bay of Bengal.

Inter-comparison of water balance components of river basins draining into selected delta districts of Eastern India.

Quantification of hydrological components in-terms of surface runoff, stream flow and evapotranspiration is important and useful in planning and management of water resources across the river basin, including downstream delta regions. River deltas water availability; management and related disaster risk are largely influenced by the hydrological state of upstream river basins. The paper presents the results of hydrological modelling (SWAT) based long-term water balance components in river basins draining into selected delta Districts of Eastern India. Mahanadi, Brahmani-Baitarani river basins and Hooghly river and adjacent small river basins are considered. The long-term water balance components of Mahanadi and Brahmani-Baitarani river basins are similar and significantly different in Hooghly river and adjacent small river basins. The runoff coefficient is significantly higher in Hooghly river and adjacent small river basins at 0.39 compared to other two river basins (0.247 & 0.256). The evapotranspiration component is relatively low in Hooghly river and adjacent small river basins with smaller range of long-term variation. The time-series model outputs brought out the basin-specific hydrological response variations in low and high rainfall years such as changes in fraction of evapotranspiration and surface runoff. Mahanadi and Brahmani-Baitarani river basins exhibit large inter-annual variation in evapotranspiration, surface runoff fractions. The developed hydrological modelling framework is capable of incorporating future climate data and to predict the basin-scale future water availability, demand, use and to bring out resulting water scenarios that would impact river deltas in-terms of their exposure towards water related adversities, such as drought and flood.

Comorbidities in Lichen Planus: A Case-control Study in Indian Patients.

BACKGROUND: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, metabolic syndrome, thyroid dysfunction, and hepatitis C virus (HCV) infection. MATERIALS AND METHODS: The study included 75 patients with clinical diagnosis of LP and 75 age- and sex-matched controls. After taking complete history, general examination and thorough dermatological examination were performed in all cases. Fasting serum samples were taken from all cases and controls and assayed for fasting plasma glucose, lipid profile, T3, T4, and thyroid-stimulating hormone levels, and anti-HCVantibodies. Metabolic syndrome was diagnosed according to 2005 revised National Cholesterol Education Programme's Adult Treatment Panel III. Two-sample Student's t-test was used for statistical analysis. RESULTS: Increased triglyceride levels were seen in 26 cases (34.67%) compared with 14 controls (14%), which was significant (P = 0.024). Statistically significant increased prevalence of increasedlow-density lipoprotein levels (P = 0.027), low high-density lipoprotein levels (P = 0.0189), and diabetes mellitus (P = 0.0217) was also observed in LP. Metabolic syndrome (P = 0.656) and hypothyroidism (P = 0.117) were not significantly associated with LP. Strong association was observed between oral LP and hypothyroidism. All patients screened for anti-HCV antibodies were found to be negative. CONCLUSION: There is a clear associationof LP with dyslipidemia and diabetes mellitus. Screening for dyslipidemia and diabetes mellitus in all patients of LP will help in early detection, initiation of treatment, and prevent long-term morbidity.

Readiness of Accredited Social Health Activist Workers for Tobacco Cessation Counseling after a Brief Intervention in Odisha, India: A Quasi-experimental Study.

AIM: The aim of the study was (1) to explore the baseline beliefs and practices of accredited social health activist (ASHA) workers of Khurda district of Orissa with respect to tobacco cessation and (2) to assess whether a brief intervention will be effective in improving the beliefs and practices of ASHA workers. The results of this study could be utilized by policy makers for framing important strategies for tobacco cessation in rural areas utilizing ASHA workers. MATERIALS AND METHODS: A quasi-experimental study (before and after comparison) was performed in Khurda district of Orissa to find out whether a brief intervention could improve the beliefs and practices of ASHA workers related to antitobacco counseling in rural areas. A 14-item structured, interviewer-administered questionnaire, written in English (translated in Odiya), was used. The final sample size was estimated as 135. Data were entered into Statistical Package for the Social Sciences (version 21) for analysis. RESULTS: All the mean belief items, practice items, degree of preparedness, and interest in training scores of study population increased significantly from baseline to postintervention. The study population showed a statistically significant improvement in postintervention composite belief and composite practices score. CONCLUSION: The majority of ASHA workers had positive beliefs and favorable practices after attending a brief intervention toward smoking cessation in their community. After attending the intervention, nearly half of the respondents felt themselves either somewhat or very well prepared for tobacco cessation. Most of them showed their interest toward getting further training in the field. CLINICAL SIGNIFICANCE: Training programs and regular tobacco cessation activities should be planned in the primary health-care delivery system of India.

Awareness and training need of biomedical waste management among undergraduate students, Andhra Pradesh.

Total 463 undergraduate students (216 males & 247 females) of ASRAM medical college of Andlira Pradesh were surveyed regarding awareness about biomedical waste management. Most of the students have heard about biomedical waste. Some of them were aware that it causes health hazards. But knowledge about category of wastes, duration of waste storage, responsibility of waste, type of bags used for collection, identification of Biohazard symbol was poor. Awareness of Biomedical waste. management and Handling rule 1998 was also poor. There were gaps in various aspects of Biomedical waste management among medical students. Appropriate training or inclusion of a topic in undergraduate medical curriculum can fulfill this.

Endovascular stent implantation in the coeliac and superior mesenteric arteries in the treatment of chronic mesenteric ischemia.

Mesenteric ischemia is a rare but serious cause of abdominal pain.We present the case of a man who had symptomatic mesenteric ischemia, secondary to a superior mesenteric artery stenosis in conjunction with a coeliac artery stenosis. He was treated with balloon angioplasty and stent insertion, and showed good symptomatic improvement.

Skin disease: clinical indicator of immune status in human immunodeficiency virus (HIV) infection.

BACKGROUND: Dermatological manifestations are seen at every stage of HIV/AIDS (human immunodeficiency virus), and are often the presenting features. These manifestations not only act as markers but also reflect the underlying immune status. OBJECTIVE: To establish skin diseases as clinical indicators of underlying immune status in HIV disease by estimating and correlating with the CD(4), CD(4) : CD(8) ratio. MATERIALS AND METHODS: The CD(4), CD(8), CD(4) : CD(8) ratios were estimated using the fluorescence activated cell sorter (FACS) count system in 20 asymptomatic HIV patients, 80 HIV patients with various skin manifestations and 72 healthy volunteers as the control group. RESULTS: In comparison with the CD(4) cell count of the control group (mean 885/mm(3), standard deviation 331), that of the HIV-positive individuals (mean 409.83/mm(3), standard deviation 263.07) was statistically correlated with low counts (z = 10.099 and P < 0.05). Similarly there was statistical significance with the CD(4) : CD(8) ratio among these two groups. In comparison with the CD(4) cell count of the asymptomatic HIV-positive individuals (mean 620.65/mm(3) and standard deviation 262.065), the CD(4) cell count of the HIV-positive patients with various dermatological manifestations (mean 357.15/mm(3), standard deviation 236.95) was statistically correlated with low counts (z = 4.0978 and P < 0.05). Similarly there was statistical significance with the CD(4) : CD(8) ratio among these two groups. CONCLUSIONS: There was an inverse relation between the CD(4) counts and the incidence and severity of skin diseases in the HIV/AIDS patients. Cutaneous manifestations of HIV can be considered as good clinical indicators to predict and access the underlying immune status in resource-poor countries.

Periodontal implications of Class II restorations. Clinical and SEM evaluation.

30 subjects with class II silver amalgam restorations were studied to evaluate the influence of these restorations on periodontal health of the adjacent region. The incidence of overhangings were noted. The periodontal changes were recorded with the help of indices. The surface of the restoration and the interface between the restoration and the cavity margin were observed on extracted teeth under SEM. The gingival and periodontal status at the site of the restoration were affected by the restoration and the restoration showed a rough surface as compared to the enamel on SEM examination.