ABSTRACT
Stroke, though considered a thromboembolic disorder, is known to be associated with hyperlipidaemia. In Western country, some workers have performed studies exploring the role of lipids in stroke in their country. Such a study is lacking in Indian population. This study was therefore conducted to observe the role of lipids in stroke by evaluating 13 parameters of lipids in 48 patients of non haemorrhagic cerebral stroke hospitalised in acute condition and compared with those of 70 age matched normal subjects. Results revealed that phospholipids and arachidonic acid were significantly altered in patients of acute stroke.
Subject(s)
Cerebrovascular Disorders/blood , Lipids/blood , Acute Disease , Adult , Female , Humans , Male , Middle AgedABSTRACT
The present study was undertaken to evaluate and compare the lipid profiles of various laboratory animals to that of human beings. The human subjects and animals included in the study were from three age groups based on key physiological states. A record of the usual dietary constituents and their daily consumption was maintained. The results indicated that the lipid profile of pigs and dogs bears similarity to that of human beings. Results also revealed that lipid profile was labile in the second group of these animals indicating that this age is suitable to bring about the required changes to produce a hyperlipidemic animal.
Subject(s)
Drug Evaluation, Preclinical , Hypolipidemic Agents/pharmacology , Animals , Dogs , Guinea Pigs , Humans , Male , Mice , Poultry , Rabbits , Rats , Rats, Inbred Strains , SwineABSTRACT
PIP: Lipid metabolism of women on combination oral contraceptives (OCs) (Lynestrenol and Primovlar ED) was studied. Serum lipids of 15 women on OCs for less than 5 years and 39 on OCs for more than 5 years were compared with each other and also with a control group of 22 women, in whom basal readings were obtained before starting the study. No significant changes were obtained in women on OCs for total lipids, esterified cholesterol, triglycerides, and alpha- and beta-lipoproteins. A significant rise (P .05) in total serum cholesterol was observed in women on OCs for more than 5 years as compared with the control group. A significant rise was also seen in free cholesterol in both groups of OC users as compared with controls (P .05).^ieng
