[Role of autonomic dysfunction syndrome in the etiology of pre-stroke forms of cerebrovascular pathology in women of young age]. / Rol' sindroma vegetativnoi distonii v geneze doinsul'tnykh form tserebrovaskuliarnoi patologii u zhenshchin molodogo vozrasta.

30 women aged 30-45 years with the diagnosis "initial manifestations of insufficiency of cerebral circulation" were examined. These disorders were observed on the background of the syndrome of autonomic dysfunction. Correlative analysis was performed by means of methods which permitted quantitative estimations on the basis of investigation of the severity of the syndrome, peculiarities of the patients' mental state and cerebral hemodynamics. Pronounced correlation was found between hemodynamic indices and the degree of anxieties. Anxiety plays an inducing role in the development of either autonomic dysfunction or the main vascular disorders. The syndrome of autonomic disfunction was considered as the realising factor.

[The characteristics of the autonomic disorders in acute cerebral circulatory disturbances]. / Osobennosti vegetativnykh rasstroistv pri ostrykh narusheniiakh mozgovogo krovoobrashcheniia.

The problem of the role of the autonomic nervous system (ANS) in the mechanism of symptom formation and in the pathogenesis of acute disturbances of cerebral circulation (ADCC) has not been studied well. Bearing this in mind, the authors examined 78 patients who suffered ADCC. The patients were divided into 2 groups. The first group was made up of 50 patients who suffered ischemic brain stroke with a stable neurological defect (SSD), the second one comprised 28 patients who suffered brain stroke with a reversible neurological defect (SRD). It has been established as a result that the initial level of sympatheticotonia and the intensity of the signs of vegetodystonia was higher in patients with SSD. Electrophysiological studies have demonstrated that in SRD, the level of ascending nonspecific brain activation prevailed according to the responsiveness of the reference alpha-rhythm as compared with the first group patients and the control group. The data obtained are discussed from the standpoint of the compensatory role played by the autonomic nervous system in the pathogenesis and course of the clinical forms of ADCC differing in the gravity and prognosis.

[Criteria of pharmacologic effectiveness of antioxidant and membrane-stabilizing drugs in various disorders of cerebral circulation]. / Kriterii farmakologicheskoi éffektivnosti antioksidantnykh i membranostabiliziruiushchikh lekarstvennykh sredstv pri razlichnykh narusheniiakh mozgovogo krovoobrashcheniia.

The criteria of the effectiveness of preparations possessing the antioxidative and membrane reparative properties in 135 patients with different clinical forms of disorders of the cerebral circulation were developed. It was found that the effectiveness of antioxidative and membrane stabilizing drugs in relieving consequences of free radical aggression as compared with traditional means varied and manifested itself in such an order: essenciale----alpha-tocopherol----unithiol. The presented methods of therapy and appropriate drugs may be recommended for the introduction in the complex of therapeutic and rehabilitative measures.

[Indices of cell membrane disorganization in patients with disorders of cerebral circulation]. / Pokazateli dezorganizatsii kletochnykh membran u bol'nykh s narusheniem mozgovogo krovoobrashcheniia.

Altogether 101 patients with various forms of cerebral circulation disorders have been examined for the red cell membrane status. The levels of diene conjugates, malonic dialdehyde, Schiff's bases in the red cell membranes, blood viscosity, and red cell mechanical instability and deformability time have been under study. The findings evidence a relationship between the cellular membrane structural and functional disarrangement and the disease severity. Assessment of the aforesaid characteristics may become an important criterion in the diagnosis and prognosis of such diseases.

[Characteristics of the erythrocyte membranes in normal subjects]. / Kharakteristika membran éritrotsitov zdorovykh liudei.

Examinations of 80 healthy donors aged 18 to 68 (40 females and 40 male ones) have been carried out to define the physiochemical constants of red cell membranes, study the lipid peroxidation products, and determine phospholipid fractions in health. The findings characterize the standard values of the constants of red cell membranes in normal subjects of various ages; they may be used as the criterion of health in hot climate areas.

[Pathogenesis of "diurnal" and "nocturnal" strokes]. / Nekotorye voprosy patogeneza "dnevnykh" i "nochnykh" mozgovykh insul'tov.

A comprehensive clinico-physiological investigation involved 23 patients of whom 13 had had a "diurnal" and 10 a "nocturnal" cerebral stroke. The structure of the nocturnal sleep was studied by polygraphic recording; the authors also studied the circadian rhythm of the clotting properties of blood, pulse blood filling of the cerebral vessels and arterial pressure. It was found that the structure of dream in patients with a history of a "nocturnal" stroke was characterized by an increase in the activity of the mechanisms responsible for the phase of rapid sleep. Characteristic features of the circadian dynamics of the hemostatic system and hemodynamic parameters in patients with a history of a "diurnal" and "nocturnal" stroke were identified. A conclusion is drawn that the circadian distribution of acute disturbances of the cerebral blood circulation is determined by individual characteristics of some circadian rhythms of the patients' bodies.

[Electrophysiologic features of sleep and wakefulness in focal epilepsy with lateralization of the focus to the left and right cerebral hemispheres]. / Elektrofiziologicheskie osobennosti sna i bodrstvovaniia pri ochagovoi épilepsii s lateralizatsiei fokusa v levom i pravom polushariiakh golovnogo mozga.

Forty-two epileptic patients with distinct localization of the focus in the left (22 patients) and the right (20 subjects) hemispheres of the brain were subjected to a combined electrophysiological examination including electroencephalography at rest and under intellectual exertion and also polygraphic recording of the night dream pattern. On the basis of the data obtained the authors analyze the function of the cerebral nonspecific activating and deactivating systems in relation to the localization of the focus. The differences detected are suggestive of the functional insufficiency of the activating mechanisms in the left lateral localization of the focus as compared with the right lateral one. The feasibility of utilizing the findings obtained in the differential management of epilepsy (with the lateralization of the epileptic focus taken into account) is discussed.

[Characteristics of disorders of nocturnal sleep in myocardial infarct based on polygraphic data]. / Kharakteristika narushenii nochnogo sna pri infarkte miokara po dannym poligrafii.

In 25 patients with acute myocardial infarction objective signs of sleep disorders and the restoration trends of its separate phases and stages after the infarction are described. The data obtained can be used for adequate qualitative and quantitative correction of sleep disorders in acute myocardial infarction at different stages of the disease.