ABSTRACT
The hepatic blood flow and monooxygenase system activity were studied in 68 ischemic [correction of coronary] heart disease patients aged 37-68 [correction of 40-80] years who had functional class III-IV effort angina and 12 healthy volunteers matched by age. An analysis of the finding indicated that in patients with angina pectoris, the hepatic blood flow index decreased, the pharmacokinetic parameters of antipyrin impaired, the degree of these impairments depended on the severity of the clinical course of angina pectoris.
Subject(s)
Liver Circulation , Liver/enzymology , Myocardial Ischemia/physiopathology , Oxygenases/blood , Adult , Aged , Angina Pectoris/enzymology , Angina Pectoris/physiopathology , Antipyrine/blood , Humans , Male , Middle Aged , Myocardial Ischemia/enzymology , Physical ExertionABSTRACT
CCl4 given to Chinchilla rabbits aged 1 month caused impaired pharmacokinetics of cardiogrin, indicating suppression of absorptive and excretory functions of the liver in prepuberty. Silibor was found to produce no substantial restorative effects on hepatic absorptive and excretory functions in acute toxic hepatitis in the growing body. Phytin was shown to be not inferior to zyxorin and benzonal was superior to all the agents under study in activity.
Subject(s)
Chemical and Drug Induced Liver Injury/drug therapy , Indocyanine Green/pharmacokinetics , Liver/drug effects , Acute Disease , Animals , Barbiturates/therapeutic use , Benzhydryl Compounds/therapeutic use , Carbon Tetrachloride Poisoning/complications , Carbon Tetrachloride Poisoning/drug therapy , Carbon Tetrachloride Poisoning/physiopathology , Chemical and Drug Induced Liver Injury/etiology , Chemical and Drug Induced Liver Injury/physiopathology , Drug Evaluation, Preclinical , Enzyme Induction/drug effects , Flavonoids/therapeutic use , Liver/physiopathology , Phytic Acid/therapeutic use , Plant Extracts/therapeutic use , RabbitsABSTRACT
Hexenal, meprobamate, amidopyrine and ethylmorphine produced a significantly marked effect in animals under hypokinesia as compared with normal rats. When phytin, benzonal and their combination were used for preventive purposes, impaired pharmacodynamics of the tested drugs metabolizing in the liver disappeared. The investigations demonstrated that the preventive use of phytin in combination with benzonal is the most optimal in correcting the impairments of drug pharmacodynamics in hypokinesia.
Subject(s)
Barbiturates/pharmacology , Immobilization/physiology , Liver/drug effects , Phytic Acid/pharmacology , Aminopyrine/pharmacokinetics , Aminopyrine/pharmacology , Animals , Barbiturates/administration & dosage , Biotransformation/drug effects , Drug Interactions , Ethylmorphine/pharmacokinetics , Ethylmorphine/pharmacology , Hexobarbital/pharmacokinetics , Hexobarbital/pharmacology , Liver/metabolism , Male , Meprobamate/pharmacokinetics , Meprobamate/pharmacology , Phytic Acid/administration & dosage , Rats , Time FactorsABSTRACT
Intragastric CCl4 inhibited the activity of and lowered the levels of the major components of the hepatic monoohygenase enzyme system in one-month rats. Benzonal was found to be more effective in correcting the impaired monooxygenase enzyme system of hepatic cells in immature rats with acute hepatitis than silibor, phytin and zyxorin.
Subject(s)
Chemical and Drug Induced Liver Injury/drug therapy , Cytochrome P-450 Enzyme System/biosynthesis , Liver/drug effects , Microsomes, Liver/drug effects , Sexual Maturation/drug effects , Acute Disease , Animals , Carbon Tetrachloride Poisoning/complications , Carbon Tetrachloride Poisoning/drug therapy , Carbon Tetrachloride Poisoning/enzymology , Chemical and Drug Induced Liver Injury/enzymology , Chemical and Drug Induced Liver Injury/etiology , Cytochrome P-450 Enzyme System/drug effects , Drug Evaluation, Preclinical , Enzyme Induction/drug effects , Female , Male , Microsomes, Liver/enzymology , Oxygenases/drug effects , Oxygenases/metabolism , Rats , Time FactorsABSTRACT
It has been established in experiments on 30 day albino rats that in acute hepatitis, the pharmacodynamics of the test drugs hexenal, amidopyrine and ethylmorphine metabolized in the liver is considerably potentiated. In contrast to silibor, phytin and zixorine, experimental therapy with benzonal brings about a complete recovery of the pharmacodynamics of the drugs under study. It is believed that benzonal holds promise in pediatrics as a remedy that restores the detoxifying potency of the liver.
Subject(s)
Carbon Tetrachloride Poisoning/metabolism , Chemical and Drug Induced Liver Injury/metabolism , Liver/metabolism , Pharmaceutical Preparations/metabolism , Animals , Carbon Tetrachloride Poisoning/drug therapy , Chemical and Drug Induced Liver Injury/drug therapy , Drug Interactions , Female , Liver/drug effects , Male , RatsABSTRACT
Young rats aged 14 days were subjected to malnutrition during 3.7 and 14 days. Activity of the main microsomal enzymes and lipid peroxidation (LPO) products in the microsomal cytosol fraction of the liver was studied in the test and control (aged 17.21 and 28 days) animals. It has been found that constant malnutrition leads to elevation of amidopyrine demethylase activity and inhibition of c-reductase and aniline hydrolase NADP.H cytochrome activities, as well as to a decreased content of protein and cytochrome P-450 in the liver. At the same time the levels of conjugated dienes and diene-ketones in the microsomal-cytosol fraction of the liver significantly rise that denotes activation of LPO in the microsomal membranes. It has been suggested that the suppression of the monooxygenase system function during malnutrition induces inhibition of the intensity of biotransformation of xenobiotics, including drugs which is responsible for intensification of pharmacodynamics and toxicity of the latter. These conditions should be taken into consideration during drug therapy in patients with malnutrition.
