[Thyroid functional activity in an experiment upon exposure to manganeferous dust].

The purpose of the study was to examine the effect of polymetallic manganeferous dust on thyroid function in an experiment. Biochemical and cytological studies were used. Seventy-day exposure caused decreased thyroid hormonal levels and thyroid cellular composition changes, which suggest that the dust in question has a cytotoxic effect. A prolonged (3-month) exposure provided evidence that suggests the tension of adaptive mechanisms in the thyroid system under the influence of a toxic factor. Nitric oxide was found to take an active part in the formation of adaptive mechanisms in thyroid tissue.