ABSTRACT
Distinct alterations in content of cyclic nucleotides were observed during treatment of 133 patients with fractures of long tubular bones. The following effects were found after initial increase in cAMP content: increase in tissue permeability, aseptic inflammation, inhibition of cell mitosis, acceleration of cell enzymes synthesis, of protein biosynthesis and of the rate of microcirculation in the traumatized region. Elevation of cGMP concentration led to initiation of bone marrow proliferation, to augmented formation of organic matrix and its mineralization. Monitoring of cyclic nucleotides concentration enabled to evaluate the reparative osteogenesis activity.
Subject(s)
Cyclic AMP/metabolism , Cyclic GMP/metabolism , Fractures, Closed/metabolism , Fibula/injuries , Fracture Fixation , Fractures, Closed/therapy , Humans , Tibia/injuries , Wound HealingSubject(s)
Bone and Bones/blood supply , Fracture Fixation, Internal , Leg Injuries/physiopathology , Osteogenesis , Adult , Aged , Aging/physiology , Bone and Bones/diagnostic imaging , Humans , Leg Injuries/diagnostic imaging , Leg Injuries/surgery , Middle Aged , Radionuclide Imaging , TechnetiumABSTRACT
In 12 non-inbred 4-month-old puppies a closed brachial transcondylar fracture has been performed. By means of photonic absorbtiometry contents of mineral components have been estimated in the regenerate forming between the osseous broken pieces, in the osseous fragments and in the adjoining segment, depending on duration of the joint fixation during the treatment. Mineralization takes place more quickly in a mobile joint. Fixation for 5-7 days does not essentially affect the miniralization rate. Fixation for 14 days decreases intensity of the mineralization, produces deminiralization in the osseous pieces and in the adjoining segment of the bone, results in incompleteness of the brachial condyle rearrangement.
