Queering Hookup Motives in a Diverse Sample of LGBTQ+ Young Adults.

There is a paucity of research on hookup motives among LGBTQ+ young adults, despite the importance of such sexual encounters for the development of LGBTQ+ young adults' identities. In this study, we examined the hookup motives of a diverse sample of LGBTQ+ young adults through in-depth qualitative interviews. Interviews were conducted with 51 LGBTQ+ young adults across college campuses at three sites in North America. We asked participants, "What sorts of things motivate you to hook up?" and "Why do you hook up?" Six distinct hookup motives emerged from participants' responses. They included: a) pleasure/enhancement, b) intimacy and social-relationship motives, c) self-affirmation, d) coping, e) cultural norms and easy access, and f) multifaceted motives. While some of our themes cohered with previously identified hookup motives among heterosexual samples, LGBTQ+ young adults identified new and distinct motives that illustrate major differences between their hookup experiences and that of heterosexual young adults. For example, LGBTQ+ young adults were motivated to pleasure their hookup partner, not just themselves. They were also motivated by cultural norms within the queer community, easy access to hookup partners, and multifaceted motives. There is a need for data-driven ways to conceptualize hookup motives among LGBTQ+ young adults, instead of unquestioningly using heterosexual templates for understanding why LGBTQ+ individuals hook up.

Antioxidant capacity and cytotoxic effect of an optimized extract of isabella grape (Vitis labrusca) on breast cancer cells.

The phenolic profile of Isabella grape (Vitis labrusca) offers beneficial properties to human health and makes it a functional food product. In order to better understand the phenolic compounds found in this grape variety and the biological effect they induce on breast cancer cells, an ultrasound-assisted extraction was carried out. During the extraction of polyphenols from Isabella grapes organically grown in Antioquia (Colombia), parameters such as frequency (33 kHz and 40 kHz), time and solvent were optimized to finally obtain a crude extract with antioxidant properties (Oxygen Radical Absorbance Capacity, ORAC: 293.22 ± 34.73 µmol of Trolox/g of sample), associated with a total polyphenol content (TPC) of 43.14 ± 5.00 mg GAE/g sample and a total anthocyanin content composed of 17.69 ± 2.59 mg of malvidin-3-glucoside/100 g of sample. MCF-7 breast cancer cells were treated with different concentrations of the optimized extract, and results show a decrease in cell viability related to mitochondrial membrane depolarization, ROS increase, and chromatin condensation. To determine the possible death induction mechanism, molecular docking was simulated to predict the molecular interactions between the most abundant phenolic compounds in Isabella grape and the main apoptosis-related proteins. The results obtained from in silico and in vitro experiments were consistent with each other, suggesting that the phenolic compounds found in Isabella grape can be considered potential adjuvant chemopreventive agents for the treatment of breast cancer.

On optimal temozolomide scheduling for slowly growing glioblastomas.

Background: Temozolomide (TMZ) is an oral alkylating agent active against gliomas with a favorable toxicity profile. It is part of the standard of care in the management of glioblastoma (GBM), and is commonly used in low-grade gliomas (LGG). In-silico mathematical models can potentially be used to personalize treatments and to accelerate the discovery of optimal drug delivery schemes. Methods: Agent-based mathematical models fed with either mouse or patient data were developed for the in-silico studies. The experimental test beds used to confirm the results were: mouse glioma models obtained by retroviral expression of EGFR-wt/EGFR-vIII in primary progenitors from p16/p19 ko mice and grown in-vitro and in-vivo in orthotopic allografts, and human GBM U251 cells immobilized in alginate microfibers. The patient data used to parametrize the model were obtained from the TCGA/TCIA databases and the TOG clinical study. Results: Slow-growth "virtual" murine GBMs benefited from increasing TMZ dose separation in-silico. In line with the simulation results, improved survival, reduced toxicity, lower expression of resistance factors, and reduction of the tumor mesenchymal component were observed in experimental models subject to long-cycle treatment, particularly in slowly growing tumors. Tissue analysis after long-cycle TMZ treatments revealed epigenetically driven changes in tumor phenotype, which could explain the reduction in GBM growth speed. In-silico trials provided support for implementation methods in human patients. Conclusions: In-silico simulations, in-vitro and in-vivo studies show that TMZ administration schedules with increased time between doses may reduce toxicity, delay the appearance of resistances and lead to survival benefits mediated by changes in the tumor phenotype in slowly-growing GBMs.

Estudio bibliométrico de la producción científica encontrada en Scopus y Web Of Science sobre rehabilitación vocal fisiológica / Bibliometric analysis of the scientific production found in Scopus and Web Of Science about physiological vocal rehabilitation

Introducción: El presente estudio analiza la producción científica internacional encontrada en Scopus y Web of Science relacionada con la Corriente de Rehabilitación Vocal Fisiológica en el periodo 2006 a 2015. Metodología: Estudio exploratorio-descriptivo con 3 fases de desarrollo: a) selección de palabras clave y criterios de búsqueda; b) búsqueda y sistematización de información; c) análisis de la información. Resultados: La mayor producción científica se identifica en la herramienta de búsqueda Scopus bajo el criterio de búsqueda «voice therapy». Se analizaron un total de 167 publicaciones, realizando correlaciones a partir de las variables año, criterios de búsqueda, autores, factor de impacto por cuartil y por citación. Conclusión: Existe alta correlación y grado de solapamiento entre ambas bases de datos. Sin embargo, Scopus comparada con Web of Science, con relación a las líneas de la Corriente de Rehabilitación Vocal Fisiológica y para el periodo estudiado, presentó un mayor porcentaje de producción científica. Las líneas con mayor impacto científico son «terapia Lee Silverman» y «ejercicios de la función vocal». «Ejercicios TVSO» y «terapia de voz resonante», con menos porcentaje de publicaciones, desde 2011 incrementan progresivamente factores de alto impacto

Introduction: The present study looks at the international scientific production found in Scopus and Web of Science, related to the Physiological Vocal Rehabilitation Current in the period 2006-2015. Methodology: Exploratory-descriptive study with three phases of development: A) selection of keywords and search criteria; B) search and systematization of information; C) analysis of information. Results: The highest scientific production is identified in the Scopus search tool under the "voice therapy" search criterion. A total of 167 publications were analyzed, making correlations from the year, search criteria, authors, impact factor by quartile and by citation variables. Conclusion: There is a high correlation and degree of overlap between the two databases. However, Scopus compared to Web of Science, in relation to the Physiological Vocal Rehabilitation Current lines and for the period studied, presented a higher percentage of scientific production. The lines with the greatest scientific impact are "Lee Silverman therapy" and "vocal function exercises". "SOVT exercises" and "resonant voice therapy", with less percentage of publications, since 2011 progressively increase high impact factors

A Patient Presenting with Cholangitis due to Stenotrophomonas Maltophilia and Pseudomonas Aeruginosa Successfully Treated with Intrabiliary Colistine.

Anatomical barriers for antibiotic penetration can pose a particular challenge in the clinical setting. Stenotrophomonas maltophilia (SM) and Pseudomonas aeruginosa (PA) are two pathogens capable of developing multiple drug-resistance (MDR) mechanisms. We report the case of a 56-year-old female patient with a permanent percutaneous transhepatic biliary drainage (PTBD), who was admitted to our hospital with a cholangitis due to a MDR Escherichia coli strain. Upon admission, culture-guided antimicrobial therapy was conducted and the biliary catheter was replaced, with poor clinical response. Subsequently, SM and PA were detected. Treatment with fosfomycin and colistine was initiated, again without adequate response. Systemic colistine and tigecycline along with an intrabiliary infusion of colistine for 5 days was then used, followed by parenteral fosfomycin and tigecycline for 7 days. The patient was then successfully discharged. This is the first case report we are aware of on the use of intrabiliary colistine. It describes a new approach to treating cholangitis by MDR bacteria in patients with a PTBD.

Effects on vitamin A deficiency in children of periodic high-dose supplements and of fortified oil promotion in a deficient area of the Philippines.

Regular semi-annual distribution of high-dose (200,000 IU) vitamin A capsules (VACs) to children 1 - 5 years of age (previously identified as underweight), in Leyte Province, the Philippines, was compared to providing extra VACs to give three-monthly dosing, and to vitamin A-fortified cooking oil (VAFO) promotion (with continued VACs every 6 months). Serum retinol (SR) was measured at baseline and after 12 or 18 months (for VAFO). No sustained increase in SR was determined from the three-month VAC dosing regimen, and the prevalence of vitamin A deficiency (VAD) as assessed by SR (< 20 mcg / dL) remained around 30 % (in line with national survey estimates over the previous 15 years). The major difference found was that 18 months of VAFO (of which 9 months had sustained promotion) was associated with reducing the prevalence of VAD to < 10 %. The effective fortification and lack of effect of semi-annual VAC results are in line with previous studies; testing with dosing of VAC every three months is a new intervention. The results imply that promotion of fortified oil would reduce VAD in these conditions; whether it can replace or needs to be added to semi-annual VAC dosing remains to be determined. A phased changeover to reliance on fortified commodities (including oil) with careful monitoring of VAD trends is indicated.

Aspectos clínicos y epidemiológicos del herpes genital en ginecología y su asociación con otras enfermedades de tanasmisión sexual / m

Se realiza un estudio en 40 pacientes que padecen de vulvovaginitis por herpes virus, el cual comprendió una serie de análisis clinicopatológicos y virológicos realizados al 50 por ciento de ellas. Se indica que se les tomó una muestra endocervical y se les realizó un exudado vaginal en busca de otros gérmenes asociados de transmisión sexual, y también se efectuó un estudio serológico, con la aplicación de la técnica de veneral disease reaction laboratory (VDRL). Se informa que entre las características clínicas, las lesiones vesicoulcerosas fueron las más frecuentes, el edema vulvar fue leve en el 65,0 por ciento de las pacientes, la localización vulvar fue del 100,0 por ciento; entre los síntomas locales, el ardor vulvar, la disuria vulvar y las adenopatías inguinales dolorosas fueron los más frecuentes. Se encuentra que el 77,5 por ciento de las pacientes estudiadas tenía un estudio citológico positivo al herpes virus y el estudio virológico fue positivo en el 100 por ciento de las mismas. Se expresa que al analizar la asociación de herpes virus con otros gérmenes de transmisión sexual, se comprueba que el 45 por ciento tenía Candida Albicans, el 32,5 por ciento Trichomonas vaginalis y el 6,5 por ciento, Neisseria gonorrhoea (AU)