ABSTRACT
Chronic hepatitis C virus infection (HCV) is classically associated with such dermatologic conditions as mixed cryoglobulinemia (MC), porphyria cutanea tarda (PCT) and lichen planus. This review focuses on the response of these entities to interferon alpha (IFN) therapy, which has an immunomodulatory activity and may modify their course. The presence of certain HCV-associated dermatologic disorders, as PCT, may predict the patients virological response to IFN therapy. On the other hand, the course of some dermatologic disorders, as MC, during treatment with IFN, may be an early indicator of virologic response. In any case, physicians should know how to handle the most common dermatologic side effects of IFN, which may affect the quality of life of patients, complicating the adherence to treatment.
Subject(s)
Antiviral Agents/adverse effects , Drug Eruptions/etiology , Hepatitis C, Chronic/drug therapy , Interferon-alpha/therapeutic use , Mouth Diseases/chemically induced , Antiviral Agents/therapeutic use , Female , Humans , Middle Aged , Mouth MucosaABSTRACT
La infección crónica por el virus de la hepatitis C se asocia clásicamente con entidades dermatológicas como la crioglobulinemia mixta (CM), la porfiria cutánea tarda (PCT) o el liquen plano. Esta revisión se centra en la respuesta de estos trastornos cutáneos al tratamiento con interferón alfa (IFN), que posee una actividad inmunomoduladora y puede modificar su evolución. Parece que la presencia de ciertas manifestaciones dermatológicas por sí mismas, como la PCT, pueden predecir la respuesta virológica a IFN. Por otro lado, el curso de ciertos desórdenes dermatológicos, como la CM, durante el tratamiento con IFN puede ser un indicador precoz de la respuesta virológica. En cualquier caso, es importante que los facultativos conozcan los efectos cutáneos adversos del IFN, que pueden afectar de forma importante la calidad de vida de los pacientes, condicionando su adherencia al tratamiento(AU)
Chronic hepatitis C virus infection (HCV) is classically associated with such dermatologic conditions as mixed cryoglobulinemia (MC), porphyria cutanea tarda (PCT) and lichen planus. This review focuses on the response of these entities to interferon alpha (IFN) therapy, which has an immunomodulatory activity and may modify their course. The presence of certain HCV-associated dermatologic disorders, as PCT, may predict the patients virological aresponse to IFN therapy. On the other hand, the course of some dermatologic disorders, as MC, during treatment with IFN, may be an early indicator of virologic response. In any case, physicians should know how to handle the most common dermatologic side effects of IFN, which may affect the quality of life of patients, complicating the adherence to treatment(AU)
Subject(s)
Humans , Female , Adult , Interferon-alpha/therapeutic use , Hepatitis C/complications , Hepatitis C/diagnosis , Cryoglobulinemia/complications , Porphyrias/complications , Lichen Planus/complications , Plasmapheresis , Vasculitis, Leukocytoclastic, Cutaneous/complications , Hypertrichosis/complications , Hyperpigmentation/complications , Interferon-alpha/administration & dosage , Interferon-alpha/adverse effects , Hepatitis C/metabolism , Hepatitis C/physiopathology , Odds Ratio , Confidence IntervalsABSTRACT
Describimos el caso de una paciente con vainas peripilares por utilizar peinados a tensión tipo cola de caballo. El problema se resolvió fácilmente con el uso de lociones queratolíticas. Las vainas peripilares son una modificación estructural del cabello. Son unas masas de queratina que envuelven el tallo piloso. Instrumentos sencillos, como una lupa, pueden ayudarnos a distinguirlas de su principal diagnóstico diferencial, la Pediculosis capitis(AU)
We describe the case of a female patient with hair casts due to her hairstyle (a pulled-back ponytail). The problem was solved very easily with keratolytic lotions. Hair casts are a structural variation of the hair. They are keratin accretions encircling a segment of the hair shaft. They must be differentiated from pediculosis capitis with simple tools such as a magnifying glass(AU)
Subject(s)
Humans , Female , Child , Hair Follicle , Hair Follicle/pathology , Keratins/therapeutic use , Pediculus capitis/administration & dosage , Pediculus capitis/therapeutic use , Hair , Hair/pathology , Hair Diseases/diagnosis , Hair Diseases/drug therapy , Diagnosis, Differential , Scalp , Scalp/pathology , Scalp Dermatoses/diagnosis , Scalp Dermatoses/drug therapySubject(s)
Antimetabolites, Antineoplastic/adverse effects , Deoxycytidine/analogs & derivatives , Drug Eruptions/etiology , Fluorouracil/analogs & derivatives , Lupus Erythematosus, Cutaneous/chemically induced , Aged , Capecitabine , Colorectal Neoplasms/drug therapy , Deoxycytidine/adverse effects , Facial Dermatoses/chemically induced , Female , Fluorouracil/adverse effects , HumansSubject(s)
Dermatitis, Atopic , Eyelid Diseases , Kaposi Varicelliform Eruption , Acyclovir/administration & dosage , Acyclovir/therapeutic use , Adolescent , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Antiviral Agents/administration & dosage , Antiviral Agents/therapeutic use , Cloxacillin/administration & dosage , Cloxacillin/therapeutic use , Dermatitis, Atopic/diagnosis , Dermatitis, Atopic/drug therapy , Drug Therapy, Combination , Eyelid Diseases/diagnosis , Eyelid Diseases/drug therapy , Female , Follow-Up Studies , Humans , Kaposi Varicelliform Eruption/diagnosis , Kaposi Varicelliform Eruption/drug therapy , Ointments , Time Factors , Treatment OutcomeABSTRACT
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