ABSTRACT
A 24-year-old man developed a severe pleuropulmonary infection with Mycobacterium kansasii 18 months after receiving a kidney transplant from his mother. Intestinal malabsorption with severe diarrhea and a skin abscess disappeared and his pneumonia was cured when Rifampin was administered. This suggested that generalized dissemination with M. kansasii may have been present.
Subject(s)
Kidney Transplantation , Postoperative Complications , Tuberculosis, Pulmonary/etiology , Adult , Humans , Immunosuppression Therapy/adverse effects , Male , Mycobacterium Infections, Nontuberculous/drug therapy , Mycobacterium Infections, Nontuberculous/etiology , Rifampin/therapeutic use , Transplantation, Homologous , Tuberculosis, Pulmonary/drug therapyABSTRACT
Studies were undertaken in 33 uremic patients with or without hypertension, 11 normal subjects, and 15 essential hypertensive patients to assess cardiac hemodynamics, plasma volume, extracellular fluid volume, and peripheral renin levels. Cardiac output and intraarterial blood pressure were measured and peripheral vascular resistance index calculated. These studies suggest that uremic hypertension with normal renin values and hypervolemia is hemodynamically sustained by an increase in peripheral resistance rather than by an increased cardiac output. The renin angiotensin system plays a secondary role as compared to overexpansion in the genesis of hypertension in normoreninemic uremic hypertension.
