1.
Eur J Med Chem
; 162: 334-347, 2019 Jan 15.
Article
in English
| MEDLINE
| ID: mdl-30453244
ABSTRACT
We describe the first examples of small molecules able to disrupt the nanomolar interaction between the pro-apoptotic protein PUMA and its anti-apoptotic counterpart BcL-xL in malignant cells. Based on molecular modelling studies, we propose a rationale to this result, through a new "bottle-opener"-type strategy which could be of general use in the area of protein-protein interaction studies.