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Nephrology (Carlton) ; 20(1): 1-5, 2015 Jan.
Article in English | MEDLINE | ID: mdl-25231593

ABSTRACT

BACKGROUND: Bioimpedance spectroscopy (BIS), ultrasound lung comets (ULC) and serum biomarkers (N-terminal pro-brain natriuretic peptide, NT-proBNP) have all been used to assist clinicians to determine hydration status in dialysis patients. METHODS: We performed simultaneous BIS, ULC and NT-proBNP measurements in 27 peritoneal dialysis patients to determine the concordance of the three methods. RESULTS: Patients with evidence of increasing lung congestion (as determined by ultrasound) were more likely to be diabetic, have systolic hypertension and have higher NT-proBNP (r = 0.65, P < 0.0005). Although there was a trend for patients with high ULC to be overhydrated as determined by BIS, this did not reach statistical significance. Moreover, the correlation between BIS and NT-proBNP (though statistically significant at r = 0.47, P < 0.02) appeared to be weaker. CONCLUSION: BIS and ULC may be complementary, providing different information, whereas BIS may be more specific to hydration. ULC and NT-proBNP may indicate left ventricular failure coexisting with overhydration.


Subject(s)
Lung/diagnostic imaging , Natriuretic Peptide, Brain/blood , Peptide Fragments/blood , Peritoneal Dialysis , Biomarkers/blood , Body Water , Cross-Sectional Studies , Electric Impedance , Female , Humans , Male , Middle Aged , Spectrum Analysis/methods , Ultrasonography
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