Molecularly imprinted polymer containing fluorescent graphene quantum dots as a new fluorescent nanosensor for detection of methamphetamine.

A novel fluorescent nanosensor based on graphene quantum dots embedded within molecularly imprinted polymer (GQDs@MIP) was developed for detection and determination of methamphetamine (METH). The resulting GQDs@MIP nanocomposite exhibited higher methamphetamine selectivity in comparison with corresponding non-imprinted polymer (GQDs@NIP). Characterization of the GQDs@MIP nanocomposite was done by nitrogen adsorption and desorption analysis (BET method), transmission electron microscopy (TEM), photoluminescence (PL), ultraviolet-visible (UV-Vis), and Fourier transform infrared (FT-IR) spectroscopies. The fluorescence intensity of GQDs@MIP was efficiently quenched in the presence of methamphetamine template molecules while no quenching was observed in the presence of other analytes such as amphetamine, ibuprofen, codeine, and morphine. Using this method, the detection limit of 1.7 µg/L was obtained for methamphetamine determination.

Vitamin D deficiency in relation to general and abdominal obesity among high educated adults.

PURPOSE: To assess the association of vitamin D deficiency with general and abdominal obesity among high educated Iranian adults. METHODS: Current cross-sectional study was done on 500 Iranian professors aged 35 years or more. Complete data on general and abdominal obesity as well as serum 25(OH)D concentrations were available for 352 persons. Obesity was considered as body mass index ≥ 30, and abdominal obesity as waist circumference ≥ 80 cm for women and ≥ 94 cm for men. Furthermore, vitamin D deficiency was defined as serum 25(OH)D < 30 ng/ml. RESULTS: Mean age of study population was 53.03 ± 7.15 years. Compared with those in the first quartile of serum 25(OH)D, participants in the fourth quartile were less likely to be generally obese (OR 0.46, 65% CI 0.22-0.99). Such finding was also seen even after taking potential confounders into account. Furthermore, we found an inverse association between serum 25(OH)D and abdominal obesity in fully adjusted model (OR 0.44, 95% CI 0.22-0.86). In addition, a significant positive association was found between vitamin D deficiency and obesity; such that after controlling for potential confounders, participants with vitamin D deficiency had 2.16 and 2.04 times greater odds for having general (OR 2.16, 95% CI 1.05-4.45) and abdominal obesity (OR 2.04, 95% CI 1.16-3.60), respectively, than those with normal levels of vitamin D. CONCLUSION: Serum 25(OH)D concentrations were inversely associated with general and abdominal obesity. In addition, vitamin D deficiency was positively associated with both general and abdominal obesity. LEVEL OF EVIDENCE: Level V, cross-sectional descriptive study.