ABSTRACT
Background: Physical and chemical factors of workplace, either alone or in combination, contribute to oxidative stress that is harmful to the body. The combined impact of physical and chemical components of the work environment on oxidative stress was examined in this research. Methods: Research articles published from 2000 to 2021 on this topic in reliable national and international databases were collected and analyzed. Based on the preliminary screening, 120 articles were selected for the first stage. The relevance and quality of 85 suitable papers were found appropriate and evaluated by examining the purpose of the study in the next phase. Results: The data collected and presented from the articles cover simultaneous exposure to physical risk factors such as noise, radiation, and chemicals such as metal solvents, as well as different types of oxidative stress parameters like MDA, GHS, LOP, 8-OHdG, SOD, CAT, ROS, and other parameters such as research site, co-exposure effects, and target organ. Investigating the combined effect of physical and chemical variables on oxidative stress in the target organs, as well as the interaction of multiple effects on each other, was one of the key goals of the articles (synergistic, reinforcing, additive or antagonistic). Conclusion: Most of the findings of theses researches generally highlight the synergistic impact of concurrent exposure to chemical and physical risk factors on oxidative stress.
ABSTRACT
Fire accidents in storage tanks are of great importance due to the difficulty in extinguishing and ease of spread to nearby products. This study aimed to introduce a framework based on FTA-based Set Pair Analysis (SPA) established via experts' elicitation to identify and assess the risk of storage tank fire. In the quantitative FTA of a system, sufficient data are only sometimes available to calculate the failure probability of the system appertains to study. Thus, the obtained result of the SPA added new value to the Basic Events (BEs) and estimated top event. To illustrate the applicability of the proposed approach, a fault tree of the methanol storage tank fire is performed and analyzed BEs. According to the obtained results, the fire accident was computed by 48 BEs, and the occurrence probability value of the top event was estimated 2.58E-1/year. In addition, the most crucial paths that led to the fire accident are listed in this study. The proposed approach established in the present study can assist decision-makers in determining where to take preventative or appropriate action on the storage tank system. Moreover, it can be adjusted for various systems with limited manipulation.
Subject(s)
Fires , Methanol , Accidents , Risk AssessmentABSTRACT
The human reproductive system can be affected by occupational exposure to many physical and chemical risk factors. This study was carried out to review the studies conducted on the issue of the pathophysiological effects of occupational physical and chemical risk factors on the reproductive system of females and males. In this systematic review, the databases such as "Google Scholar," "Pub-Med," "Scopus," and "Web of Science" were used. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA 2020), the studies included in our study were published between 2000 and 2021. In order to extract the required data, all sections of the articles were reviewed. Out of 57 articles we reviewed, 34 articles were related to field studies and 23 articles to clinical studies. Among them, 43 studies dealt with the pathophysiological effects of chemical agents, six studies dealt with the pathophysiological effects of physical factors, and 8 studies dealt with the pathophysiological effects of physicochemical factors on the human reproductive system. Physical (noise, heat, and radiofrequency radiation) and chemical (such as carbamate and organophosphate pesticides, benzene, toluene, xylene, formaldehyde, NO2, CS2, manganese, lead, nickel, and n-hexane) risk factors had pathophysiological effects on the human reproductive system. The presence of these risk factors in the workplace caused damage to the human reproductive system. The rate of these negative pathophysiological effects can be reduced by performing appropriate managerial, technical, and engineering measures in work environments.
