ABSTRACT
An eight-year-old girl developed optic neuritis followed by primary Sjögren's syndrome confirmed by a lip biopsy. Glucocorticoid therapy combined during six months with monthly intravenous pulse cyclophosphamide ensured resolution of the sicca syndrome but failed to improve the visual impairment. This is the second pediatric case of optic neuritis associated with primary Sjögren's syndrome, and the first pediatric case in which optic neuritis was the only neurologic manifestation.
Subject(s)
Intracranial Hypertension/complications , Optic Neuritis/etiology , Sjogren's Syndrome/complications , Adolescent , Biopsy, Needle , Child , Diagnosis, Differential , Female , Follow-Up Studies , Glucocorticoids/therapeutic use , Humans , Intracranial Hypertension/diagnosis , Intracranial Hypertension/pathology , Optic Neuritis/diagnosis , Optic Neuritis/drug therapy , Prednisolone/therapeutic use , Sjogren's Syndrome/diagnosisABSTRACT
Switching the development focus of computer-based instruction from the concerns of delivery technology to the fundamentals of instructional methodology, is a notion that has received increased attention among educational theorists and instructional designers over the last several years. Building upon this precept, a proposed methodology and computer support system is presented for distilling educational objectives into concept maps using strategies derived from cognitive theory. Our system design allows for a flexible and extensible architecture in which an educator can create instructional modules that encapsulate their teaching strategies, and mimics the adaptive behavior used by experienced instructors in teaching complex educational objectives.
