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Int J Tuberc Lung Dis ; 18(4): 435-7, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24670698

ABSTRACT

We analysed the impact of the Xpert(®) MTB/RIF molecular test on health-care diagnostic delay among tuberculosis patients. Diagnostic delay was 17.2 days (standard deviation 23.2, median 10 days). Of 128 patients recruited into the study, 60 (47%) were smear-negative; of these, 40 (67%) were Xpert-positive and were started on treatment without culture. The sensitivity of smear microscopy was 53% compared with 82% for Xpert. In smear-negative patients, delay in Xpert-positive and -negative patients was respectively 15.5 ± 13.2 and 25.5 ± 12.5 days (P = 0.002). We conclude that Xpert results were significantly associated with shorter health-care diagnostic delay, particularly in smear-negative patients.


Subject(s)
Bacteriological Techniques , DNA, Bacterial/genetics , Molecular Diagnostic Techniques , Mycobacterium tuberculosis/genetics , Tuberculosis, Pulmonary/diagnosis , Adolescent , Adult , DNA, Bacterial/isolation & purification , Delayed Diagnosis , Female , Humans , Male , Microscopy , Middle Aged , Mycobacterium tuberculosis/isolation & purification , Predictive Value of Tests , Retrospective Studies , Sputum/microbiology , Time Factors , Tuberculosis, Pulmonary/microbiology , Young Adult
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