1.
Org Lett
; 24(45): 8331-8336, 2022 11 18.
Article
in English
| MEDLINE
| ID: mdl-36346151
ABSTRACT
An advantageous and original synthesis of fentanyl is described. This new approach includes two efficient continuous flow reductive aminations achieved via photoredox catalysis and a final batch acylation. A telescoped protocol for the two photocatalyzed steps is also presented, and overall, this protocol provides improved sustainability, significant efficiency, reduced temperatures and reaction times, and is functional for scaling up this relevant active pharmaceutical ingredient (API).