Subject(s)
Blood Vessels/pathology , Melanoma/pathology , Skin Neoplasms/pathology , Skin/blood supply , Aged , Humans , Male , Neoplasm Metastasis , Skin/pathology , Time FactorsABSTRACT
We present a case of purely hypopigmented mycosis fungoides of 8-years duration in an 18-year-old woman who responded readily to psoralen plus ultraviolet A (PUVA) treatment. The literature pertaining to hypopigmented mycosis fungoides is reviewed.
Subject(s)
Hypopigmentation/etiology , Mycosis Fungoides/diagnosis , PUVA Therapy , Skin Neoplasms/diagnosis , Adolescent , Diagnosis, Differential , Female , Ficusin/therapeutic use , Humans , Mycosis Fungoides/complications , Mycosis Fungoides/drug therapy , Photosensitizing Agents/therapeutic use , Skin Neoplasms/complications , Skin Neoplasms/drug therapy , Treatment OutcomeABSTRACT
Imported fire ant sting reactions are becoming an increasing problem in the United States. It is important for clinicians to be familiar with their possible cutaneous and noncutaneous presentations. We present 3 cases with multiple fire ant stings, followed by a review of the literature.
Subject(s)
Ants , Insect Bites and Stings/diagnosis , Adolescent , Adult , Aged , Aged, 80 and over , Animals , Ants/immunology , Female , Humans , Insect Bites and Stings/immunology , Male , Venoms/immunologyABSTRACT
Chromoblastomycosis, or chromomycosis, is a chronic fungal infection of the skin and subcutaneous tissues caused by a species of dematiaceous fungi. We present a patient with chromoblastomycosis due to Fonsecaea pedrosoi, who was treated with 8 months of terbinafine 250 mg by mouth daily with histologic and mycologic cure.
Subject(s)
Antifungal Agents/administration & dosage , Chromoblastomycosis/drug therapy , Naphthalenes/administration & dosage , Antifungal Agents/adverse effects , Biopsy , Chromoblastomycosis/diagnosis , Chromoblastomycosis/pathology , Dose-Response Relationship, Drug , Drug Administration Schedule , Humans , Male , Middle Aged , Naphthalenes/adverse effects , Skin/pathology , TerbinafineABSTRACT
Periorbital edema associated with lupus erythematosus is not frequently reported. To our knowledge, periorbital edema from increased dermal mucin has not been reported with any form of lupus. We present a patient with discoid lupus exhibiting periorbital edema from massive mucinosis.
Subject(s)
Lupus Erythematosus, Discoid/complications , Mucinoses/complications , Orbital Diseases/complications , Acute Disease , Adult , Edema/complications , Female , Humans , Mucinoses/pathology , Orbital Diseases/pathologyABSTRACT
We present the first reported cases of tinea nigra treated with terbinafine. Two cases responded to treatment with topical terbinafine; one case failed to respond to treatment with systemic terbinafine.
Subject(s)
Antifungal Agents/therapeutic use , Naphthalenes/therapeutic use , Tinea Pedis/drug therapy , Administration, Topical , Adult , Female , Humans , Male , Middle Aged , TerbinafineABSTRACT
Sticky skin has been reported relatively infrequently in the literature in association with etretinate and doxorubicin/ketoconazole administration. It has a poorly understood pathogenesis, and the associated histologic changes have not been described. We report a case of a patient who experienced sticky skin in areas treated with tretinoin. These reverted to normal after cessation of treatment. In comparison to a biopsy taken while the skin was not sticky, the histologic findings included a thickened, compact stratum corneum and granulosum. The basal epithelial cells showed proliferation with slight crowding and a tall, columnar shape. To our knowledge, this is the first report of sticky skin occurring in response to topical retinoid application. We suggest that the histologic changes observed could represent a modified keratin maturation profile.
Subject(s)
Dermatitis, Allergic Contact/etiology , Drug Eruptions/etiology , Keratolytic Agents/adverse effects , Tretinoin/adverse effects , Administration, Cutaneous , Adult , Humans , Keratolytic Agents/administration & dosage , Male , Thorax , Tretinoin/administration & dosageABSTRACT
Cutaneous hypersensitivity reactions to vitamin K are rare. They occur almost exclusively with fat-soluble vitamin K (K1). The lesion is most commonly a pruritic, indurated plaque at the site where the vitamin was injected. Most plaques resolve within 4 to 8 week without sequelae, but some progress to produce scar-like changes that may last for years.
Subject(s)
Drug Hypersensitivity/etiology , Vitamin K/adverse effects , Adult , Biopsy , Blood Coagulation Disorders/drug therapy , Drug Hypersensitivity/pathology , Erythema/pathology , Female , HumansABSTRACT
BACKGROUND: Controversy over the rate of malignant transformation of actinic keratosis (AK) into cutaneous squamous cell carcinoma (SCC) has generated considerable debate regarding the importance of treating all such precancers to preclude their transofrmation. Current changes in US healthcare policy will deny many individuals access to certain simple and effective treatment modalities for precancerous lesions. OBJECTIVE: Our purpose was to determine whether there is a significant association between the presence of cutaneous SCC and pre-existing AK. METHODS: One hundred and sixty five consecutive cases of cutaneous SCC, retrieved from the files of a university-affiliated dermatopathology laboratory serving north-central Florida, were selected for review by a single dermatopathologist (D.M.). Hematoxylin and eosin stained skin tissue slides were examined under light microscopy for the presence of AK in close proximity to, or giving rise to, cutaneous SCC. RESULTS: Of the 165 cutaneous SCC cases reviewed, 82.4% (136 out of 165) were found to have concomitant AK giving rise to and/or in close proximity to SCC. Of the 136 AK-positive SCC cases, 26.7% (44) were identified as superficial SCC arising within an AK (AKSSCC) and 55.7% (92) had AK in close proximity to SCC (AK + SCC). Close proximity is defined to include AK changes located directly adjacent to (on the shoulder of) SCC, to a maximum distance of 8 mm away. CONCLUSIONS: The 82.4% prevalence of concomitant AK and cutaneous SCC in our biopsy population suggests a strong correlation between these two lesions. The fact that 26.7% of these lesions had SCC arising from AK highlights the importance of early recognition and effective treatment for AK.
Subject(s)
Carcinoma, Squamous Cell/pathology , Keratosis/pathology , Precancerous Conditions/pathology , Skin Neoplasms/pathology , Biopsy , Carcinoma in Situ/pathology , Humans , Skin/pathologySubject(s)
Child Abuse/diagnosis , Urticaria Pigmentosa/diagnosis , Diagnosis, Differential , Female , Humans , InfantABSTRACT
We describe congenital cutaneous candidiasis (CCC) in a term newborn. The mother had candidal vaginitis 1 week before delivery. At birth, the infant had a generalized, intensely erythematous, papulovesicular eruption, respiratory distress and elevation of liver function tests. The child responded well to intravenous amphotericin B plus topical and oral nystatin. There have been 13 previously reported cases of CCC in infants weighing more than 1500 gm who had evidence of systemic infection. Two deaths were attributed to candidal pneumonia and sepsis. The majority of infants with CCC have infection localized to the skin, but if there is any evidence of respiratory distress or signs of sepsis the possibility of systemic candidiasis and the need for parenteral antifungal therapy must be considered.
Subject(s)
Candidiasis, Cutaneous/congenital , Candidiasis, Cutaneous/diagnosis , Respiratory Distress Syndrome, Newborn/etiology , Amphotericin B/administration & dosage , Antifungal Agents/administration & dosage , Candidiasis/transmission , Candidiasis, Cutaneous/drug therapy , Candidiasis, Vulvovaginal , Drug Therapy, Combination/administration & dosage , Female , Humans , Infant, Newborn , Infectious Disease Transmission, Vertical , Liver Function Tests , Nystatin/administration & dosage , Pregnancy , Pregnancy Complications, InfectiousSubject(s)
Lip Diseases/pathology , Oral Ulcer/pathology , Stomatitis, Aphthous/pathology , Adult , Biopsy , Diagnosis, Differential , Humans , Lip/pathology , Male , Mouth Mucosa/pathology , Recurrence , SyndromeSubject(s)
Breast Neoplasms, Male/complications , Neurofibromatosis 1/complications , Paget's Disease, Mammary/complications , Aged , Axilla , Biopsy , Breast Neoplasms, Male/pathology , Breast Neoplasms, Male/surgery , Diagnosis, Differential , Humans , Lymph Node Excision , Male , Mastectomy, Radical , Paget's Disease, Mammary/pathology , Paget's Disease, Mammary/surgerySubject(s)
Adenoma/pathology , Angiolipoma/pathology , Lipoma/pathology , Neoplasms, Basal Cell/pathology , Neoplasms, Multiple Primary/pathology , Parathyroid Neoplasms/pathology , Skin Neoplasms/pathology , Head and Neck Neoplasms/pathology , Humans , Male , Middle Aged , Papilloma/pathology , SyndromeABSTRACT
A 5-month-old boy with erythrokeratoderma variabilis is presented. The parents noted that the asymptomatic erythematous plaques changed over the course of hours to days. Topical therapy with retinoic acid proved ineffective. A brief review of the literature is presented.
