ABSTRACT
The amplified Mycobacterium tuberculosis (M tuberculosis) direct test (MTD) is reported to be a highly sensitive (92.6%) and specific (100%) test for the detection of M tuberculosis. We report two cases of human leprosy in which false-positive amplified MTD testing on skin biopsies led to initial misdiagnoses of cutaneous M tuberculosis.
Subject(s)
Leprosy/diagnosis , Mycobacterium leprae/isolation & purification , Mycobacterium tuberculosis/isolation & purification , Tuberculin Test/methods , Tuberculosis, Cutaneous/diagnosis , Aged , Diagnosis, Differential , False Positive Reactions , Humans , Leprosy/microbiology , Male , Young AdultABSTRACT
Relapsing polychondritis (RP) is a rare multisystem disorder affecting cartilaginous tissues, primarily of the ears, nose, larynx, and trachea. RP shows dermatologic manifestations in 35-50% of cases, and may show skin findings as the first sign of disease in 12% of affected patients. There have been reports of urticarial-like lesions in RP, typically associated with vasculitis, as well as a few reports of erythema multiforme-like lesions. There has also been one previous report of erythema annulare centrifugum associated with RP, presenting with a histology suggestive of a drug eruption. Our patient presented with urticarial and erythema annulare centrifugum-like plaques preceding the diagnosis of RP by over 1 year, with an initial histology suggestive of a drug eruption.
Subject(s)
Polychondritis, Relapsing/pathology , Skin/pathology , Aged , Anti-Inflammatory Agents/therapeutic use , Biopsy , Humans , Male , Polychondritis, Relapsing/drug therapy , Prednisone/therapeutic useSubject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Multiple Myeloma/pathology , Skin Neoplasms/pathology , Biopsy , Fatal Outcome , Humans , Lymphocyte Transfusion , Male , Middle Aged , Multiple Myeloma/drug therapy , Recurrence , Skin Neoplasms/drug therapy , Stem Cell Transplantation/adverse effects , Transplantation, HomologousABSTRACT
Toxic epidermal necrolysis and Stevens-Johnson syndrome are acute life-threatening dermatoses characterized by extensive sloughing and mucositis. At the University of Florida, we use practical guidelines for the management of these gravely ill patients. These can be of help to other practitioners.
Subject(s)
Stevens-Johnson Syndrome/therapy , Humans , Immunoglobulins, Intravenous/therapeutic use , Immunologic Factors/therapeutic use , Wounds and Injuries/therapySubject(s)
Aminoquinolines/administration & dosage , Angiogenesis Inhibitors/administration & dosage , Fingers , Granuloma, Pyogenic/drug therapy , Skin Diseases/drug therapy , Administration, Topical , Aminoquinolines/therapeutic use , Angiogenesis Inhibitors/therapeutic use , Humans , Imiquimod , Male , Middle Aged , Recurrence , Treatment OutcomeSubject(s)
Dermatomycoses/diagnosis , Aged , Antifungal Agents/administration & dosage , Cryotherapy , Dermatomycoses/complications , Dermatomycoses/pathology , Dermatomycoses/therapy , Diabetes Mellitus, Type 2 , Diagnosis, Differential , Forearm/pathology , Heart Failure , Humans , Male , Mitosporic Fungi/isolation & purification , Naphthalenes/administration & dosage , TerbinafineSubject(s)
Dermatologic Agents/therapeutic use , Elastic Tissue/drug effects , Granuloma, Giant Cell/drug therapy , Hydroxychloroquine/therapeutic use , Quinacrine/therapeutic use , Skin Diseases, Papulosquamous/drug therapy , Aged , Elastic Tissue/pathology , Exanthema/drug therapy , Giant Cells/pathology , Granuloma, Giant Cell/pathology , Humans , Lymphocytes/pathology , Male , Skin Diseases, Papulosquamous/pathology , Treatment OutcomeABSTRACT
Lichen planus actinicus is a photodistributed variant of lichen planus that most often occurs in individuals with dark complexions. Sunlight seems to be a triggering factor in most cases. Several clinical morphologic patterns have been described, and multiple therapies with variable results have been used. The lesions in some patients may remit spontaneously with sun avoidance.
Subject(s)
Lichen Planus/diagnosis , Diagnosis, Differential , Facial Dermatoses/diagnosis , Facial Dermatoses/pathology , Hand Dermatoses/diagnosis , Hand Dermatoses/pathology , Humans , Lichen Planus/pathology , Male , Middle AgedABSTRACT
Primary cutaneous blastomycosis and primary cutaneous sphaeropsidale infections are rare in children. We present a 6-year-old immunosuppressed girl who had a solitary ulceration on her left lower leg which showed histopathologic findings of blastomycosis. She responded readily to oral itraconazole.
