ABSTRACT
White fibrous papulosis of the neck is a rare entity, with a benign course and unknown pathogenesis. It is clinically characterized by the appearance of firm, persistent, usually asymptomatic, non-follicular papules located on the neck. We present the case of a 72-year-old patient who presented pruritic lesions on the neck whose biopsy was compatible with this entity.
ABSTRACT
Resumen Introducción: La micosis fungoide es el linfoma primario de células T en piel más frecuente, con expresividad clínica heterogénea. Objetivo: Reportar las variedades clínicas y las características sociodemográficas de pacientes con micosis fungoide tratados en un hospital dermatológico. Métodos: Se incluyeron 290 pacientes con diagnóstico clínico e histopatológico de micosis fungoide atendidos en el transcurso de 11 años. Se realizó descripción sociodemográfica de los pacientes, quienes se clasificaron conforme las variantes clínicas e histopatológicas. Resultados: 58 % de los casos de micosis fungoide se presentó en mujeres y 42 % en hombres. La variedad clínica más común fue la clásica en 46.2 %; la discrómica representó 35.2 %, del cual la hipopigmentada fue la más representativa (7.6 %); la poiquilodérmica constituyó 4.1 % y la foliculotrópica, 3.1 %. La variedad papular se presentó en seis pacientes (2.1 %), la de placa única en tres (1 %) y la ictiosiforme, siringotrópica y la piel laxa granulomatosa, en un paciente cada una. La variedad granulomatosa se encontró en 0.7 % y 1.4 % presentó eritrodermia. Conclusiones: La variedad clínica más frecuente de micosis fungoide fue la clásica en fase de placa, seguida de las variedades discrómicas. Otras variedades clínicas representaron 18.6 %.
Abstract Introduction: Mycosis fungoides (MF) is the most common primary skin T-cell lymphoma, which is characterized for a heterogeneous clinical expressivity. Objective: To report clinical variants and sociodemographic characteristics in patients with MF under the care of a dermatological hospital. Methods: 290 patients with MF clinical and histopathological diagnosis attended to over the course of 11 years were included. Sociodemographic description of patients was made, who were classified according to clinical and histopathological variants. Results: MF was recorded in 57.9 % of women and 42 % of men. The most common clinical variant was the classic type in 46.2 %; dyschromic variants accounted for 35.2 %, out of which hypopigmented MF was the most representative (17.6 %); poikilodermatous MF accounted for 4.1 %, and folliculotropic, for 3.1%. The papular variant occurred in six patients (2.1 %), the single-plaque variety in three (1%), and the ichthyosiform, syringotropic and granulomatous slack skin varieties occurred in one patient each. The granulomatous variant was found in 0.7 %, and 1.4 % had erythroderma. Conclusions: The most common MF clinical variant was classic plaque stage, followed by dyschromic variants. Other clinical variants accounted for 18.6 %.
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Skin Neoplasms/pathology , Mycosis Fungoides/pathology , Skin Neoplasms/classification , Skin Neoplasms/therapy , Retrospective Studies , Cohort Studies , Mycosis Fungoides/classification , Mycosis Fungoides/therapy , Treatment OutcomeABSTRACT
Giant basal cell carcinomas (GBCCs) are a strange and aggressive variety of basal cell carcinomas (BCCs); they are characterized by deep tissue invasion, rapid growth, high risk of metastasis, and a poor prognosis. GBCCs represent 0.4%-1% of all BCCs. The pathogenesis of GBCC is sometimes linked to a spontaneous mutation in the PTCH gene, mapped to the q22.33 locus of chromosome 9. The key factor in the development of GBCC, in at least 30% of the cases, is the delay in seeking medical attention (7.5 ± 3.1 years). This is associated to a poor socioeconomic level, deficient hygiene, mental illness, advanced age, and the fact that BCCs are painless lesions. The authors present a Mexican female with a 2-year ulcer diagnosed as a GBCC in the year 2000, its initial therapeutic approach, and her follow-up during the next 12 years.
Subject(s)
Carcinoma, Basal Cell/complications , Facial Neoplasms/complications , Neoplasm Recurrence, Local/complications , Skin Neoplasms/complications , Skin Ulcer/etiology , Adult , Carcinoma, Basal Cell/pathology , Disease Progression , Eye Enucleation , Face , Facial Neoplasms/pathology , Female , Follow-Up Studies , Humans , Nose Deformities, Acquired/etiology , Skin Neoplasms/pathologySubject(s)
Agriculture , Itraconazole/therapeutic use , Mycetoma/pathology , Aged , Biopsy, Needle , Edible Grain/adverse effects , Follow-Up Studies , Foot Dermatoses/drug therapy , Foot Dermatoses/etiology , Foot Dermatoses/pathology , Humans , Immunohistochemistry , Male , Mycetoma/drug therapy , Mycetoma/etiology , Risk Assessment , Severity of Illness Index , Treatment OutcomeABSTRACT
Se presenta el caso de un paciente de 63 años que cursó con un hidrocistoma apócrino múltiplo bilateral y de ambos párpados, de 8 años de evolución y cuyos tumores le fueron extirpados quirúrgicamente. El cuadro clínico es característico excepto por su multiplicidad. Los hallazgos histopatológicos son muy característicos, se analiza su relación con otras neoplasias similares originadas en otras glándulas palpebrales
