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1.
Materials (Basel) ; 16(10)2023 May 22.
Article in English | MEDLINE | ID: mdl-37241519

ABSTRACT

Fuel cell technology has developed due to diminishing dependence on fossil fuels and carbon footprint production. This work focuses on a nickel-aluminum bronze alloy as an anode produced by additive manufacturing as bulk and porous samples, studying the effect of designed porosity and thermal treatment on mechanical and chemical stability in molten carbonate (Li2CO3-K2CO3). Micrographs showed a typical morphology of the martensite phase for all samples in as-built conditions and a spheroid structure on the surface after the heat treatment, possibly revealing the formation of molten salt deposits and corrosion products. FE-SEM analysis of the bulk samples showed some pores with a diameter near 2-5 µm in the as-built condition, which varied between 100 and -1000 µm for the porous samples. After exposure, the cross-section images of porous samples revealed a film composed principally of Cu and Fe, Al, followed by a Ni-rich zone, whose thickness was approximately 1.5 µm, which depended on the porous design but was not influenced significantly by the heat treatment. Additionally, by incorporating porosity, the corrosion rate of NAB samples increased slightly.

2.
PLoS One ; 16(7): e0254893, 2021.
Article in English | MEDLINE | ID: mdl-34297748

ABSTRACT

The acquisition of Advanced Manufacturing Technologies (AMT), such as high-power fiber or CO2 laser cutting equipment, generally involves high investment levels. Its payback period is usually more extended, and there is a moderate-to-high risk involved in adopting these technologies. In this work, we present a robust model that optimizes equipment investing decisions, considers the process's technical constraint and finds an optimal production plan based on the available machinery. We propose a linear investment model based on historical demand information and take physical process parameters for a LASER cutting equipment, such as cutting speed and gas consumption. The model is then transformed into a robust optimization model which considers demand uncertainty. Second, we determine the optimal production plan based on the results of the robust optimization model and assuming that demand follows a normal distribution. As a case study, we decided on the investment and productive plan for a company that offers Laser-Beam Cutting (LBC) services. The case study validates the effectiveness of the proposed model and proves the robustness of the solution. For this specific application of the model, results showed that the optimal robust solution could increase the company's expected profits by 6.4%.


Subject(s)
Investments/economics , Lasers/standards , Manufacturing Industry/instrumentation , Models, Economic , Manufacturing Industry/economics
3.
Materials (Basel) ; 12(5)2019 Mar 07.
Article in English | MEDLINE | ID: mdl-30866523

ABSTRACT

The paper explores the applicability of laser-assisted synthesis for producing high density Cu-Al-Ni alloys with shape memory characteristics, that could be further developed towards a method of additive manufacturing of large size Cu-based shape memory alloys (SMA). The manufacturing approach consists in laser melting of elemental powder mixture in a controlled atmosphere of varying relative pressure of protective argon gas, producing alloys of 14.2 wt.% Al and Ni content varying between 2 and 4 wt.%. All the fabricated alloys are found to have attained martensitic microstructures capable of SMA specific phase transformations in the temperature range from 85 to 192 °C. Both gas pressure and content of Ni are found to affect the specific transformation temperatures, transformation enthalpies, and mechanical properties. In particular, increasing gas pressure suppresses the austenite to martensite transformation reducing microhardness. In conclusion, the selective laser melting (SLM) employed in this work is shown capable of producing high density Cu-Al-Ni SMA (porosity ≈ 2%).

4.
J Biomed Mater Res A ; 105(8): 2241-2251, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28426898

ABSTRACT

Polymer scaffolds are used as an alternative to support tissue regeneration when it does not occur on its own. Cell response on polymer scaffolds is determined by factors such as polymer composition, topology, and the presence of other molecules. We evaluated the cellular response of murine skeletal muscle myoblasts on aligned or unaligned fibers obtained by electrospinning poly(ε-caprolactone) (PCL), and blends with poly(lactic-co-glycolic acid) (PLGA) or decorin, a proteoglycan known to regulate myogenesis. The results showed that aligned PCL fibers with higher content of PLGA promote cell growth and improve the quality of differentiation with PLGA scaffolds having the highest confluence at over 68% of coverage per field of view for myoblasts and more than 7% of coverage for myotubes. At the same time, the addition of decorin greatly improves the quantity and quality of differentiated cells in terms of cell fusion, myotube length and thickness, being 71, 10, and 51% greater than without the protein, respectively. Interestingly, our results suggest that at certain concentrations, the effect of decorin on myoblast differentiation exceeds the topological effect of fiber alignment. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2241-2251, 2017.


Subject(s)
Myoblasts/cytology , Polyesters/chemistry , Tissue Scaffolds/chemistry , Animals , Cell Differentiation , Cell Line , Cell Proliferation , Decorin/chemistry , Lactic Acid/chemistry , Mice , Muscle Development , Polyglycolic Acid/chemistry , Polylactic Acid-Polyglycolic Acid Copolymer
5.
Med Eng Phys ; 37(3): 328-34, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25649961

ABSTRACT

Additive manufacturing (AM) models are used in medical applications for surgical planning, prosthesis design and teaching. For these applications, the accuracy of the AM models is essential. Unfortunately, this accuracy is compromised due to errors introduced by each of the building steps: image acquisition, segmentation, triangulation, printing and infiltration. However, the contribution of each step to the final error remains unclear. We performed a sensitivity analysis comparing errors obtained from a reference with those obtained modifying parameters of each building step. Our analysis considered global indexes to evaluate the overall error, and local indexes to show how this error is distributed along the surface of the AM models. Our results show that the standard building process tends to overestimate the AM models, i.e. models are larger than the original structures. They also show that the triangulation resolution and the segmentation threshold are critical factors, and that the errors are concentrated at regions with high curvatures. Errors could be reduced choosing better triangulation and printing resolutions, but there is an important need for modifying some of the standard building processes, particularly the segmentation algorithms.


Subject(s)
Models, Anatomic , Algorithms , Finger Phalanges/anatomy & histology , Finger Phalanges/diagnostic imaging , Humans , Image Processing, Computer-Assisted , Tomography, X-Ray Computed
6.
Article in English | MEDLINE | ID: mdl-24460089

ABSTRACT

Spinal metastatic disease could lead to catastrophic consequences for the patient. However, the structural parameters that explain the weakening of vertebrae affected by tumours are not fully understood. In this study, we developed a specimen-specific finite element model to predict the strength of the porcine vertebra with simulated tumours and used it to find the structural parameters determining the strength. We validated our model with mechanical testing and then we analysed the compressive strength of intact vertebrae and seven defects with different size and shape. The results showed that the minimum bone mineral mass of the cross section and areal defect fraction were the best predictors of the normalized strength. We also found that areal parameters appeared to be better predictors than the volumetric ones. In conclusion, reduction in bone strength for vertebrae weakened by metastatic tumours is mostly associated with decrease in the mechanical properties of the cross section.


Subject(s)
Compressive Strength/physiology , Models, Biological , Spinal Neoplasms/physiopathology , Spine/anatomy & histology , Spine/physiology , Animals , Biomechanical Phenomena , Bone Density/physiology , Humans , Swine
7.
Int J Med Robot ; 8(3): 311-8, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22411859

ABSTRACT

BACKGROUND: Determination of the mineral content of bone and its distribution by computed tomography (CT) enables one to define the insertion points for prosthetic devices, or determine the degree of healing in cases of fracture or surgical intervention. The use of subject-specific models allows mapping of the spatial structure and the mineral content of the bone graphically and quantitatively. METHODS: Subject-specific models and mineral density maps from pig jaws were developed using segmentation, transcription tools and finite element analysis software. This study considered six frozen heads from pigs aged 10-12 months, and phantom solutions of K(2) HPO(4) . The predicted bone mass of each jaw was compared with its respective ash mass after incineration. RESULTS: The tridimensional maps show highest density values at the molar cusp and within the symphysis. The average percentage error relative to the mineral density maps was -18.4%. The radiation dose was reduced by a factor of eight from the recommended maximum without compromising the precision of the models. CONCLUSIONS: The computed tridimensional mineral density maps illustrate, numerically and graphically, the spatial distribution of the density field within the mandibular bone. These maps could facilitate the location of insertion points or determine the evolution of the mineralization level of a patient's bone tissue.


Subject(s)
Bone Density , Computer Simulation , Mandible/anatomy & histology , Mandible/metabolism , Models, Anatomic , Animals , Finite Element Analysis , Imaging, Three-Dimensional , Mandible/diagnostic imaging , Phantoms, Imaging , Radiographic Image Interpretation, Computer-Assisted , Swine , Tomography, X-Ray Computed
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