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Bioorg Med Chem Lett
; 21(18): 5219-23, 2011 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-21840710
ABSTRACT
Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for α-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(α1â3)Glc and Glc(α1â3)Man disaccharides representing the linkages cleaved by α-Glucosidase II in N-glycan biosynthesis. These (N1â3)-linked pseudodisaccharides were found to have some α-Glucosidase II inhibitory activity, while two other (N1â6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme.