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1.
Gen Comp Endocrinol ; 188: 269-81, 2013 Jul 01.
Article in English | MEDLINE | ID: mdl-23660449

ABSTRACT

Like in humans, diabetes mellitus is on the rise in cats. Feline diabetes is a suitable model for human type-2 diabetes. We investigated magnitude and timing of insulin suppression with induced hyperglycaemia and its relationship to plasma and urinary ketones and to pancreatic islet insulin. IGF-I is under discussion as a protective mechanism but little is known about its role in diabetes in general and its distinct localisation in feline pancreatic islets in particular. Thirteen healthy, adult cats were allocated to 2 groups and infused with glucose to maintain their blood glucose at a high or moderate concentration for 42 days resulting in insulin secretion suppression. After initial increase, insulin levels declined to baseline but were still detectable in the blood at a very low level after 6 weeks of glucose infusion and then increased after a 3 week recovery period. While IGF-I in healthy cats was primarily located in glucagon cells, in hyperglycaemia-challenge IGF-I was pronounced in the ß-cells 3 weeks after ceasation of infusion. Six/8 cats developing glucose toxicity became ketonuric after 3-4 weeks. Gross lipaemia occurred approx 1 week prior to ketonuria. Ketonuric cats required 1-2 weeks of insulin therapy after-infusion until ß-cell recovery. In conclusion, ketosis and hyperlipidaemia are likely to occur in diabetic cats with glucose at 30 mmol/L, especially after ≥2 weeks. Three weeks after ceasation of infusions, clinical and morphological recovery occurred. We propose a local protective effect of IGF-I to support survival and insulin production in the hyperglycaemic state and recovery period.


Subject(s)
Hyperglycemia/blood , Hyperglycemia/metabolism , Insulin-Like Growth Factor I/metabolism , Insulin/blood , Insulin/metabolism , Islets of Langerhans/metabolism , Ketones/blood , Ketones/urine , Animals , Cats , Insulin-Secreting Cells/metabolism
2.
J Vet Intern Med ; 16(2): 123-32, 2002.
Article in English | MEDLINE | ID: mdl-11899027

ABSTRACT

We characterized the changes in blood glucose concentrations in healthy cats exposed to a short stressor and determined the associations between glucose concentrations, behavioral indicators of stress, and blood variables implicated in stress hyperglycemia (plasma glucose, lactate, insulin, glucagon, cortisol, epinephrine, and norepinephrine concentrations). Twenty healthy adult cats with normal glucose tolerance had a 5-minute spray bath. Struggling and vocalization were the most frequent behavioral responses. There was a strong relationship between struggling and concentrations of glucose and lactate. Glucose and lactate concentrations increased rapidly and significantly in all cats in response to bathing, with peak concentrations occurring at the end of the bath (glucose baseline 83 mg/dL, mean peak 162 mg/dL; lactate baseline 6.3 mg/dL, mean peak 64.0 mg/dL). Glucose response resolved within 90 minutes in 12 of the 20 cats. Changes in mean glucose concentrations were strongly correlated with changes in mean lactate (r = .84; P < .001) and mean norepinephrine concentrations (r = .81; P < .001). There was no significant correlation between changes in mean glucose concentrations and changes in mean insulin, glucagon, cortisol, or epinephrine concentrations. Struggling and lactate concentrations were predictive of hyperglycemia. Gluconeogenesis stimulated by lactate release is the likely mechanism for hyperglycemia in healthy cats in this model of acute stress. Careful handling techniques that minimize struggling associated with blood collection may reduce the incidence of stress hyperglycemia in cats.


Subject(s)
Cat Diseases/etiology , Diabetes Mellitus/veterinary , Hyperglycemia/veterinary , Stress, Physiological/veterinary , Animals , Behavior, Animal , Blood Glucose/analysis , Cat Diseases/blood , Cat Diseases/diagnosis , Cats , Diabetes Mellitus/blood , Diabetes Mellitus/diagnosis , Diabetes Mellitus/etiology , Epinephrine/blood , Female , Glucagon/blood , Handling, Psychological , Hydrocortisone/blood , Hyperglycemia/blood , Hyperglycemia/diagnosis , Hyperglycemia/etiology , Insulin/blood , Lactic Acid/blood , Male , Norepinephrine/blood , Stress, Physiological/blood , Stress, Physiological/complications , Stress, Physiological/diagnosis , Vocalization, Animal
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