Subject(s)
Arthritis, Rheumatoid/complications , Dizziness/pathology , Hearing Loss/pathology , Otitis/pathology , Tympanic Membrane/pathology , Adrenal Cortex Hormones/therapeutic use , Dizziness/complications , Dizziness/drug therapy , Female , Hearing Loss/complications , Hearing Loss/drug therapy , Humans , Middle Aged , Otitis/complications , Otitis/drug therapy , Treatment OutcomeABSTRACT
Hypersensitivity pneumonitis is a respiratory disease resulting from the inhalation of antigens to which the exposed subject has been previously sensitized. Hypersensitivity pneumonitis is characterized by a diffuse and predominantly mononuclear cell inflammation of the alveolar regions that involves the small airways in most cases. It explains the presence of mosaic attenuation and expiratory air trapping at HRCT Scan. Chronic bronchitis, an obstructive defect at lung function tests and emphysema as long-term outcome are frequent consequences of this bronchial involvement.
Subject(s)
Alveolitis, Extrinsic Allergic/complications , Bronchial Diseases/etiology , Alveolitis, Extrinsic Allergic/diagnosis , HumansABSTRACT
CONTEXT: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of French cancer centers (FNCLCC), the 20 French cancer centers, and specialists from French public universities, general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients. The methodology is based on a literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery. OBJECTIVES: To develop clinical practice guidelines for non small cell lung cancer patients according to the definitions of the Standards, Options and Recommendations project. METHODS: Data were identified by searching Medline , web sites, and using the personal reference lists of members of the expert groups. Once the guidelines were defined, the document was submitted for review to independent reviewers. RESULTS: This article presents the chapter "Prognosis significance of oncogenes and tumor suppressor genes" from the full report "Standards, Options and Recommendation for non small cell lung cancer" validated in August 2000. The main recommendations are: 1) No clear clinical prognostic value of oncogenes and tumor suppressor genes (p53, bcl-2, Ki-ras, c-erbB-2, Rb, p16) in non small cell lung cancer, can be established from the available evidences (standard, level of evidence C). 2) Prospective multicenter studies should be performed to assess prognostic significance of oncogenes and tumor suppressor genes in non small cell lung cancer.
