ABSTRACT
OBJECTIVE: Perforations of the tympanic membrane are treated with various surgical techniques and materials. This study aimed to determine the efficacy of platelet-rich plasma during underlay myringoplasty. METHODS: The study included 40 patients. Autologous platelet-rich plasma was applied in-between temporalis fascia graft and tympanic membrane remnant during underlay myringoplasty in group 1 (n = 20). The outcome was evaluated after three months and compared with group 2 (n = 20), a control group that underwent routine underlay tympanoplasty. RESULTS: After three months' follow up, graft uptake was 95 per cent in group 1 and 85 per cent in group 2 (p < 0.03). Mean hearing threshold gain was 18.62 dB in group 1 and 13.15 dB in group 2. This difference was statistically significant (p < 0.01). CONCLUSION: Platelet-rich plasma, with its ease of preparation technique, availability, low cost, autologous nature and good graft uptake rate, justifies its use in tympanoplasty type I procedures.
Subject(s)
Myringoplasty/methods , Platelet-Rich Plasma/physiology , Tympanic Membrane Perforation/surgery , Adolescent , Adult , Female , Hearing Tests , Humans , Male , Middle Aged , Prospective Studies , Random Allocation , Treatment Outcome , Tympanoplasty , Young AdultABSTRACT
Over several decades, a large body of evidence has emerged to suggest that depressive disorder is a risk factor for heart diseases, both aetiologically and prognostically. Several large, prospective, longitudinal studies have examined the relationship between depression and the development of coronary artery disease (CAD); they reveal that the relationship is significant and independent of conventional risk factors. Prognostic studies have shown that depression is associated with two to three times higher mortality after myocardial infarction, unstable angina or coronary artery bypass grafting, and in patients with stable CAD compared with such patients without depression. Depression also has been found to increase mortality and morbidity in patients with heart failure, regardless of its aetiology. Such adverse associations persist after adjustment for conventional prognostic risk factors. Despite all of these findings, depressed patients with heart disease are less likely to be recognised clinically as being depressed than those patients who have depression but no heart disease. The very limited evidence available from pharmacological clinical trials raises concern about the safety of antidepressants in CAD and heart failure. In addition, no research has addressed whether the treatment of depression in patients with heart disease will improve their prognosis.
Subject(s)
Coronary Disease/drug therapy , Coronary Disease/etiology , Depression/complications , Depression/drug therapy , Coronary Disease/diagnosis , Coronary Disease/psychology , Depression/diagnosis , Depression/psychology , HumansABSTRACT
INTRODUCTION: Nasal mucociliary clearance is an important physiological function of nasal cavity that helps in protecting the lower respiratory tract from undesirable organic and inorganic matter including the micro organisms. The study was designed to establish normal mucociliary clearance time in healthy children in a tropical environment. MATERIAL AND METHODS: The study was carried out in 100 randomly selected normal school children aged 4--15 years using saccharin method. The diseases that are known to affect the nasal mucociliary clearance were excluded. The study variables were age and sex. RESULTS: Mean nasal mucociliary clearance time was 5.7+/-2.59 min with no significant difference between males and females. The clearance time was found to be impaired in groups A and B including children of 4--7 and 8--11 years of age respectively. CONCLUSION: Nasal mucociliary clearance is impaired in children of either sex between 4 and 11 years probably due to subclinical adenoiditis. However clearance returns to normal level at the time of puberty, which coincides with adenoids involution.
Subject(s)
Mucociliary Clearance , Nasal Mucosa/physiology , Tropical Climate , Adolescent , Child , Child, Preschool , Female , Humans , India , Male , Mucociliary Clearance/physiology , Reference Values , Sampling Studies , Time FactorsABSTRACT
The nasal mucociliary clearance time was studied using Andersen saccharin method in 50 normal children and 50 age and sex matched patients of adenotonsillar hypertrophy, which was repeated one month after adenotonsillectomy. The normal mucociliary clearance time in healthy children was found to be 8.55 +/- 2.11 minutes. A significant impairment in nasal mucociliary clearance time was noted in children suffering with adenotonsillar hypertrophy which was 16.97 +/- 3.1 minutes, and early adenotonsillectomy restored the mucociliary clearance to a normal 8.7 +/- 2.14 minutes.
Subject(s)
Adenoids/pathology , Mucociliary Clearance/physiology , Adenoidectomy , Adenoids/surgery , Adolescent , Child , Female , Humans , Hypertrophy/physiopathology , MaleABSTRACT
Multiple papilloma of larynx is caused by human papilloma virus. We treated sixteen such cases (10 males and six females) in the last 10 years. All presented with hoarseness while six presented with difficulty in respiration. Three patients needed tracheostomy, all had difficult decanulation, and one developed laryngotracheal stenosis and could not be decanulated. All were treated by surgical excision; ten had recurrence. Four patients were treated with post operative Acyclovir with no recurrence in three cases.
Subject(s)
Laryngeal Neoplasms/diagnosis , Papilloma/diagnosis , Papillomavirus Infections/diagnosis , Tumor Virus Infections/diagnosis , Acyclovir/administration & dosage , Child , Child, Preschool , Female , Humans , Laryngeal Neoplasms/therapy , Laryngeal Neoplasms/virology , Laryngoscopy , Male , Papilloma/therapy , Papilloma/virology , Papillomavirus Infections/physiopathology , Papillomavirus Infections/therapy , Prognosis , Retrospective Studies , Tracheostomy , Tumor Virus Infections/therapy , Tumor Virus Infections/virologyABSTRACT
A case of benign symmetrical lipomatosis of neck in a 10 year, thinly built child is presented with outline of possible etiology and treatment. Since this disease barely finds mention in otolaryngotogy textbooks, although these patients usually first present to olotaryngologists, this case is reported to make aware the young fraternity with the disease entity.
