Lateralizing value of transient hypofrontality during Wada's test.

Five of 22 subjects who underwent Wada's test in our institution over last year developed transient hypofrontality, always following the injection of the side contralateral to seizure focus (as defined by prior ictal recordings). This event may have lateralizing value and could well be because of pharmacological ablation of contralateral frontal-lobe combined with compromised ipsilateral frontal-lobe causing transient hypofrontality.