ABSTRACT
We report on the occurrence of galactorrhea associated with a prolactin elevation within weeks of treatment with risperidone. One of our patients was switched to a typical antipsychotic, with an improvement in the galactorrhea. The other patient was continued on risperidone due to a robust response, while her galactorrhea was partially treated with bromocriptine. The mechanism of prolactin elevation with risperidone is unclear. These cases suggest the need for further studies.
Subject(s)
Antipsychotic Agents/adverse effects , Galactorrhea/chemically induced , Prolactin/drug effects , Psychotic Disorders/drug therapy , Risperidone/adverse effects , Adult , Antipsychotic Agents/administration & dosage , Dose-Response Relationship, Drug , Female , Galactorrhea/blood , Humans , Prolactin/blood , Risperidone/administration & dosageABSTRACT
This case vignette illustrates dramatic improvement of tardive dyskinesia (TD) in an elderly female with a long history of neuroleptic exposure, following treatment with low-dose risperidone. The TD continued to be in remission at 1-year follow-up. This observation calls for well-designed randomized studies to evaluate the efficacy of risperidone in treating TD.
