Indomethacin and meclofenamate potentiation of skeletal muscle active hyperemia.

The effects of indomethacin and meclofenamate on active hyperemia following sustained, maximal isometric contractions were studied in free-flowing dog gracilis muscles. Muscles were stimulated to contract in situ for 1, 4, 7, and 10 s durations in the absence and presence of indomethacin (62.5 micrograms/ml blood), meclofenamate (50 micrograms/ml blood), or appropriate vehicles. Drugs were administered by continuous intra-arterial infusion into the muscle. Cyclo-oxygenase inhibition was verified by intra-arterial injection of arachidonic acid. Resting vascular conductance decreased by 28% with meclofenamate but not with indomethacin. Meclofenamate and indomethacin increased active hyperemia excess flows by 49% and 101%, respectively, following 10 s of contraction. These results differ markedly from previous studies. We suggest that non-specific actions of both drugs, unrelated to their effect on prostaglandin synthesis, result in potentiation of normal vasodilator responses to muscle contraction.

Experimental internal iliac artery embolization: evaluation of low viscosity silicone rubber, isobutyl 2-cyanoacrylate, and carbon microspheres.

The angiographic, morphologic, and histologic effects of carbon microspheres, isobutyl 2-cyanoacrylate (IBC), and low viscosity silicone rubber (LVSR) were compared. Carbon spheres did not effectively occlude the internal iliac artery, but resulted in small vessel occlusions leading to the most frequent complications. IBC was effective in causing occlusion but resulted in significant inflammatory changes within the thrombus and vessel wall. LVSR gave satisfactory occlusion without inciting vessel wass inflammatory reaction. Two of 4 animals developed a hind extremity paralysis. None of these materials is approved for general intravascular usage.

Gastrointestinal angiographic findings in systemic amyloidosis.

Amyloidosis is a multisystem disease process of unknown cause in which characteristically staining protein-polysaccharide material is deposited in body tissues. Although gastrointestinal involvement is usually asymptomatic, amyloid infiltration of mesenteric and submucosal vessel walls may be associated with acute or recurrent gastrointestinal hemorrhage in patients with the diagnosis of amyloidosis. Angiography in such cases may demonstrate arterial and venous changes as a result of these vascular wall deposits. Two patients with proven amyloidosis and gastrointestinal hemorrhage are presented, and their angiographic findings are discussed with the pathologic correlations.

Biplane arteriography in ischemia of the lower extremity.

A technique for simultaneous bilateral biplane arteriography of the abdomen, pelvis, and lower extremities is described. The biplane views provided clinically significant information in approximately 40% of cases.

Pseudotumor of kidney.

Pyelocancerous backflow during retrograde pyelography is a roentgen sign indicating renal tumors. An example of a pseudotumor (renal hematoma caused by anticoagulation) is presented which displayed this type of backlfow, demonstrating the nonspecificity of the sign. The diagnostic, especially radiographic, findings of intrarenal hematoma are discussed.

Idiopathic inferior mesenteric venous thrombosis demonstrated by angiography.

Idiopathic thrombosis of the inferior mesenteric vein, not associated with portal vein thrombosis, is an uncommonly diagnosed lesion. We are reporting a case of inferior mesenteric vein thrombosis diagnosed preoperatively by angiography. We believe this to be the first case in the literature of this particular lesion demonstrated conclusively by angiography before surgery.