ABSTRACT
Anti-Sdx is an IgM complement-binding autoantibody that defines a red cell antigen which is independent of I, i, Sp1 (Pr) and Gd. Hemagglutination by the antibody is unusually sensitive to variation in pH, salt, or other charged molecular species. The antibody is inhibited by urine from Sd(a+) persons, but inhibition is a nonspecific effect caused by charged molecules. No specific Sdx substance could be demonstrated, and Sdx antigen does not appear to be directly associated with the Sid blood group. In view of these findings we propose that this antibody should be renamed anti-Rx.
Subject(s)
Autoantibodies/urine , Blood Group Antigens/immunology , Animals , Depression, Chemical , Guinea Pigs , Hemagglutination Inhibition Tests , Hemagglutination Tests , Humans , Male , Molecular Weight , Mucoproteins/pharmacology , Neuraminidase/pharmacology , Receptors, Antigen/drug effects , Sodium Chloride/pharmacology , Urine/analysis , UromodulinABSTRACT
Two cases of cerebral echinococcosis in children emphasize the need to consider the Echinococcus in the differential diagnosis of children with CNS signs and symptoms. One patient died because of delay in seeking medical attention. The other is now a 22-year-old college student with no evidence of recurrence more than five years after removal of Echinococcus cysts from both brain and liver. The newer modalities available for diagnosis are discussed. Therapy with mebendazole is reviewed; this relatively new, highly effective anthelmintic is well tolerated and has been apparently highly effective in a small number of cases.
