ABSTRACT
Antibody activity to Herpes simplex virus (HSV) types 1 and 2 was measured in sera from women with cervical dysplasia (19 cases), squamous-cell carcinoma, stages 0-4 (54 cases), other genital tumours (15 cases) and matched controls (60 cases) by the indirect immunofluorescent (IFA) test. The frequency of HSV-2 antibody activity was significantly greater in women with cervical cancer than in those with other genital tumours and in matched controls (p<0.05). No significant difference was observed for the HSV-2 antibody activity between women with cervical dysplasia and matched controls. The mean antibody titres to HSV-1 and HSV-2 were significantly higher in cancer cases than the respective titres in control groups (p<0.05). The cervical cancer cases were also analysed according to their clinical stage (Stages 0-4), and there was no significant variation either in frequency of antibody activity, or mean HSV-2 antibody titres. These preliminary findings suggest that there may be an association between HSV-2 and squamous cell carcinoma of uterine cervix in Jamaican women but further studies are required for meaningful conclusions to be drawn (AU)
Subject(s)
Female , Humans , Antibodies, Viral/isolation & purification , Carcinoma, Squamous Cell/etiology , Uterine Cervical Dysplasia/etiology , Uterine Cervical Neoplasms/etiology , Simplexvirus/immunology , Carcinoma, Squamous Cell/pathology , Uterine Cervical Neoplasms/pathology , Genital Neoplasms, Female/etiology , Genital Neoplasms, Female/pathology , JamaicaABSTRACT
A clinical and pathological study on 108 cases of endometriosis observed at the University Hospital of the West Indies during a 15-year period (1968-1982) is reported. A low incidence was found when compared with similar studies conducted elsewhere. The peak age at occurence was 36 years. Common clinical manifestations were pelvic pain, infertility, dysmenorrhoea, menorrhagia and dyspareunia. A preoperative diagnosis of endometriosis was made very infrequently. A high index of suspicion, careful clinical examination, including family history, pelvic examinatiuon and laparoscopy are required to improve the accuracy of the clinical diagnosis. The ovaries and the pelvic peritoneum were the commonest sites affected. There was a relatively high frequency of involvement of the fallopian tubes, laparotomy scars, umbilicus, uterine cervix and the vagina (AU)
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Middle Aged , Endometriosis/pathology , Genital Neoplasms, Female/pathology , Diagnosis, Differential , Endometriosis/diagnosis , Endometriosis/epidemiology , Fallopian Tube Neoplasms/pathology , Genital Neoplasms, Female/diagnosis , Genital Neoplasms, Female/epidemiology , Ovarian Neoplasms/pathology , JamaicaABSTRACT
A study on 339 cases of adenomyosis uteri observed at the University Hospital of the West Indies during the 15-year period 1966-1980 has been reported. The condition is common in the negro population of Jamaica, and occurs chiefly in multiparous women aged 35-55 years. The common clinical manifestations are lower adominal pain, lower back pain, menorrhagia and uterine enlargement. Some of the cases, however, were detected incidentally during pathological examination of the uterus for other conditions. Uterine fibroids were present in about 64 percent of cases, and myohyperplasia in more than 82 percent. There is an urgent need for uniform criteria for diagnosing adenomyosis microscopically. A greater effort in clinical examination should be made to improve the pre-operative diagnosis. We recommend that at least six sections be taken from the uterus routinely in order to exclude adenomyosis (AU)
Subject(s)
Adult , Aged , Female , Humans , Middle Aged , Endometriosis/diagnosis , Uterine Neoplasms/diagnosis , Endometriosis/pathology , Uterine Neoplasms/pathology , JamaicaABSTRACT
The clinical radiological and pathological features of two cases of pulmonary alveolar proteinosis are described. A further three cases have been diagnosed in Jamaica since 1960 and a summary of the clinical, radiological and pathological features of these cases is also presented. (AU)
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Pulmonary Alveolar Proteinosis/diagnostic imaging , Pulmonary Alveolar Proteinosis/pathology , JamaicaABSTRACT
Two cases of endometrial ossification are reported. In one patient, there were two previous abortions and it seems likely that the phenomenon resulted as a dystrophic change from foetal death in utero. In the second case, there was no history of a previous abortion and the presence of bone and cartilage probably resulted from metaplastic change in the endometrial stroma. The aetiology and pathogenesis of this unusual endometrial change are discussed (AU)
Subject(s)
Adult , Female , Humans , Endometrium/pathology , Ossification, Heterotopic/pathology , JamaicaABSTRACT
A case of cervical thymic cyst in a 16-year old male is described. The lesion is quite rare and was seen for the first time at the University Hospital of the West Indies. The literature has been reviewed and the embryology and pathogtenesis of the condition have been discussed. A pre-operative diagnosis of thymic cyst in the neck is difficult and should be included in the differential diagnosis of swellings in the neck (AU)
