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1.
Indian J Med Sci ; 56(5): 225-9, 2002 May.
Article in English | MEDLINE | ID: mdl-12649945

ABSTRACT

Cytogenetic investigations carried out on 1021 cases of Down syndrome revealed translocation in 46 cases. The most frequent was of t(14;21) and t(21;21) types. Most of the translocation DS cases (n = 31) were born to younger mothers (< 25 years), when compared to pure trisomy 21 DS cases. Parental karyotypes, family history and parental ages has helped us greatly in offering genetic counseling, prenatal diagnosis and estimating the risk for the next conception.


Subject(s)
Down Syndrome/epidemiology , Down Syndrome/genetics , Translocation, Genetic/genetics , Adolescent , Adult , Age Factors , Birth Order , Cytogenetic Analysis , Female , Heterozygote , Humans , India/epidemiology , Karyotyping , Male , Mosaicism/genetics , Parents , Risk Assessment/methods , Trisomy/genetics
2.
Indian J Med Sci ; 56(3): 122-6, 2002 Mar.
Article in English | MEDLINE | ID: mdl-12508621

ABSTRACT

Cytogenetic investigations carried on 1021 cases of Down syndrome revealed translocation in 46 cases. The most frequent was of t(14;21) and t(21;21) types. Most of the translocation DS cases (n = 31) were born to younger mother's (< 25 years), when compared to pure trisomy 21 DS cases. Parental karyotypes, family history and parental ages has helped us greatly in offering genetic counseling, prenatal diagnosis and estimating the risk for the next conception.


Subject(s)
Down Syndrome/genetics , Translocation, Genetic , Chromosomes, Human, Pair 21/genetics , Down Syndrome/epidemiology , Female , Genetic Counseling , Humans , India/epidemiology , Male , Maternal Age , Paternal Age , Pregnancy, High-Risk
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